Patents Assigned to Masimo Laboratories, Inc.
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Publication number: 20090247984Abstract: Systems that can include a microneedle array and a small molecule metabolic reporter are disclosed. The systems can be used to penetrate the epidermis and monitor the change in concentration of one or more metabolite or analyte.Type: ApplicationFiled: October 24, 2008Publication date: October 1, 2009Applicant: Masimo Laboratories, Inc.Inventors: Marcelo Lamego, Sean Merritt, Grace Young
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Patent number: 7596398Abstract: A physiological sensor is adapted to removably attach an emitter assembly and a detector assembly to a fingertip. The emitter assembly is adapted to transmit optical radiation having multiple wavelengths into fingertip tissue. The detector assembly is adapted to receive the optical radiation after attenuation by the fingertip tissue. The sensor has a first shell and a second shell hinged to the first shell. A spring is disposed between the shells and urges the shells together. An emitter pad is fixedly attached to the first shell and configured to retain the emitter assembly. A detector pad is fixedly attached to the second shell and configured to retain the detector assembly. A detector aperture is defined within the detector pad and adapted to pass optical radiation to the detector assembly. A contour is defined along the detector pad and generally shaped to conform to a fingertip positioned over the detector aperture.Type: GrantFiled: March 1, 2006Date of Patent: September 29, 2009Assignee: Masimo Laboratories, Inc.Inventors: Ammar Al-Ali, Chris Schultz
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Patent number: 7563110Abstract: A sensor interconnect assembly has a circuit substrate. An emitter portion of the substrate is adapted to mount emitters. A detector portion of the substrate is adapted to mount a detector. A cable portion of the substrate is adapted to connect a sensor cable. A first group of conductors are disposed on the substrate electrically interconnecting the emitter portion and the cable portion. A second group of conductors are disposed on the substrate electrically interconnecting the detector portion and the cable portion. A decoupling portion of the substrate disposed proximate the cable portion substantially mechanically isolating the cable portion from both the emitter portion and the detector portion so that sensor cable stiffness is not translated to the emitters or the detector.Type: GrantFiled: May 23, 2008Date of Patent: July 21, 2009Assignee: Masimo Laboratories, Inc.Inventors: Ammar Al-Ali, Yassir Abdul-Hafiz
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Publication number: 20090004108Abstract: Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.Type: ApplicationFiled: December 23, 2004Publication date: January 1, 2009Applicant: Masimo Laboratories, Inc.Inventors: Emile M. Bellott, Dongsheng Bu, James J. Childs, Christopher Lambert, Hubert A. Nienaber, Shirley J. Shi, Zhaolin Wang, Jerome J. Workman, Alex R. Zelenchuk
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Patent number: 7440787Abstract: The disclosure includes pulse oximetry systems and methods for determining point-by-point saturation values by encoding photoplethysmographs in the complex domain and processing the complex signals. The systems filter motion artifacts and other noise using a variety of techniques, including statistical analysis such as correlation, or phase filtering.Type: GrantFiled: November 28, 2005Date of Patent: October 21, 2008Assignee: Masimo Laboratories, Inc.Inventor: Mohamed K. Diab
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Publication number: 20080154104Abstract: A physiological monitor for determining blood oxygen saturation of a medical patient includes a sensor, a signal processor and a display. The sensor includes at least three light emitting diodes. Each light emitting diode is adapted to emit light of a different wavelength. The sensor also includes a detector, where the detector is adapted to receive light from the three light emitting diodes after being attenuated by tissue. The detector generates an output signal based at least in part upon the received light. The signal processor determines blood oxygen saturation based at least upon the output signal, and the display provides an indication of the blood oxygen saturation.Type: ApplicationFiled: March 10, 2008Publication date: June 26, 2008Applicant: MASIMO LABORATORIES, INC.Inventors: Marcelo M. Lamego, Mohamed Diab, Walter M. Weber, Ammar Al-Ali, Joe Kiani
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Patent number: 7343186Abstract: A physiological monitor for determining blood oxygen saturation of a medical patient includes a sensor, a signal processor and a display. The sensor includes at least three light emitting diodes. Each light emitting diode is adapted to emit light of a different wavelength. The sensor also includes a detector, where the detector is adapted to receive light from the three light emitting diodes after being attenuated by tissue. The detector generates an output signal based at least in part upon the received light. The signal processor determines blood oxygen saturation based at least upon the output signal, and the display provides an indication of the blood oxygen saturation.Type: GrantFiled: May 27, 2005Date of Patent: March 11, 2008Assignee: Masimo Laboratories, Inc.Inventors: Marcelo M. Lamego, Mohamed Diab, Walter M. Weber, Ammar Al-Ali, Joe Kiani
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Patent number: 7289835Abstract: This invention relates to methods for processing in vivo skin auto-fluorescence spectra for determining blood glucose levels. The invention also relates to methods of classifying cells or tissue samples or quantifying a component of a cell or tissue using a multivariate classification or quantification model.Type: GrantFiled: June 2, 2005Date of Patent: October 30, 2007Assignee: Masimo Laboratories, Inc.Inventors: James Mansfield, Jenny Freeman
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Patent number: 7239905Abstract: A blood constituent monitoring method for inducing an active pulse in the blood volume of a patient. The induction of an active pulse results in a cyclic, and periodic change in the flow of blood through a fleshy medium under test. By actively inducing a change of the blood volume, modulation of the volume of blood can be obtained to provide a greater signal to noise ratio. This allows for the detection of constituents in blood at concentration levels below those previously detectable in a non-invasive system. Radiation which passes through the fleshy medium is detected by a detector which generates a signal indicative of the intensity of the detected radiation. Signal processing is performed on the electrical signal to isolate those optical characteristics of the electrical signal due to the optical characteristics of the blood.Type: GrantFiled: August 16, 2005Date of Patent: July 3, 2007Assignee: Masimo Laboratories, Inc.Inventors: Esmaiel Kiani-Azarbayjany, Mohamed Kheir Diab, James M. Lepper, Jr.
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Patent number: 7027849Abstract: A blood parameter measurement system has a monitor configured to provide an oxygen saturation measurement based upon the absorption of two wavelengths of optical radiation by a tissue site. A software upgrade is installable in the monitor so as to enable the monitor to operate in conjunction with a multiple wavelength sensor. A wavelength controller is adapted to the upgrade so as to drive the sensor.Type: GrantFiled: November 21, 2003Date of Patent: April 11, 2006Assignee: Masimo Laboratories, Inc.Inventor: Ammar Al-Ali
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Patent number: 6970792Abstract: The disclosure includes pulse oximetry systems and methods for determining point-by-point saturation values by encoding photoplethysmographs in the complex domain and processing the complex signals. The systems filter motion artifacts and other noise using a variety of techniques, including statistical analysis such as correlation, or phase filtering.Type: GrantFiled: December 3, 2003Date of Patent: November 29, 2005Assignee: Masimo Laboratories, Inc.Inventor: Mohamed K. Diab
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Patent number: 6931268Abstract: A blood glucose monitoring system is disclosed which provides for inducing an active pulse in the blood volume of a patient. The induction of an active pulse results in a cyclic, and periodic change in the flow of blood through a fleshy medium under test. By actively inducing a change of the blood volume, modulation of the volume of blood can be obtained to provide a greater signal to noise ratio. This allows for the detection of constituents in blood at concentration levels below those previously detectable in a non-invasive system. Radiation which passes through the fleshy medium is detected by a detector which generates a signal indicative of the intensity of the detected radiation. Signal processing is performed on the electrical signal to isolate those optical characteristics of the electrical signal due to the optical characteristics of the blood.Type: GrantFiled: November 6, 2000Date of Patent: August 16, 2005Assignee: Masimo Laboratories, Inc.Inventors: Esmaiel Kiani-Azarbayjany, Mohamed Kheir Diab, James M. Lepper Jr.
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Patent number: 6850787Abstract: A signal processor generates basis functions and identifies at least one basis function component of a sensor signal in order to calculate a physiological measurement. The signal processor is advantageously applied to pulse oximetry so as to directly calculate oxygen saturation and so as to calculate a robust oxygen saturation measurement. In particular, a signal component transform may be calculated within a window around a derived pulse rate estimate. A signal component transform may also utilize sinusoidal basis functions, and an optimization of a signal component transform may occur at a particular frequency or a set of frequencies. A sinusoidal waveform or waveforms at that frequency or set of frequencies is generated to select associated red and infrared components of the sensor signal, and an oxygen saturation is calculated from a magnitude ratio of these components.Type: GrantFiled: June 26, 2002Date of Patent: February 1, 2005Assignee: Masimo Laboratories, Inc.Inventors: Walter M. Weber, Ammar Al-Ali, Lorenzo Cazzoli
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Patent number: D606659Type: GrantFiled: August 25, 2008Date of Patent: December 22, 2009Assignee: Masimo Laboratories, Inc.Inventors: Massi Joe E. Kiani, Marcelo Lamego, Sean Merritt, Cristiano Dalvi, Hung Vo, Johannes Bruinsma, Jeroen Poeze, Ferdyan Lesmana, Greg Olsen