Abstract: A personal thermoelectric-cooling and heating case includes a first rigid chamber and a temperature regulated second rigid chamber. The first rigid chamber accommodates electronic circuitry. The first rigid chamber also extends lengthwise along a longitudinal axis and includes a first end portion, a second end portion, and a thermoelectric-cooling device. The temperature regulated second rigid chamber includes a bay structure configured to accommodate an item that is subject to temperature regulation. The temperature regulated second rigid chamber (i) extends lengthwise along a longitudinal axis and includes a first end portion and a second end portion, (ii) is coupleable to the first rigid chamber in a lengthwise direction, and (iii) includes a direct heating element thermally coupled to the bay structure. The first rigid chamber and the temperature regulated second rigid chamber together form a housing.