Patents Assigned to Massachusetts Eye and Ear Infirmary
  • Patent number: 11564625
    Abstract: The disclosure provides tissue force sensor systems and methods for tissues, e.g., laryngeal tissue. The systems include a top housing including on an upper side an attachment mechanism for connecting the top housing to a medical device, e.g., a laryngoscope, and on a lower side a first cavity for receiving a top portion of a force measurement device such as a load cell; a bottom housing including on a lower side an attachment mechanism for connecting the bottom housing to a handle, holding system, or suspension system for holding or supporting the medical device, and on an upper side a second cavity for receiving a bottom portion of the force measurement device; and an attachment device for connecting the top housing to the bottom housing.
    Type: Grant
    Filed: September 11, 2018
    Date of Patent: January 31, 2023
    Assignee: Massachusetts Eye and Ear Infirmary
    Inventors: Allen Lee Feng, Phillip Changhun Song
  • Patent number: 11547779
    Abstract: The invention provides methods and polymer compositions for treating retinal detachment and other ocular disorders, where the methods employ polymer compositions that can form a hydrogel in the eye of a subject. The hydrogel is formed by reaction of (i) a nucleo-functional polymer that is a biocompatible polymer containing a plurality of thio-functional groups —R1-SH wherein R1 is an ester-containing linker, such as a thiolated poly(vinyl alcohol) polymer and (ii) an electro-functional polymer that is a biocompatible polymer containing at least one thiol-reactive group, such as a poly(ethylene glycol) polymer containing alpha-beta unsaturated ester groups.
    Type: Grant
    Filed: January 13, 2022
    Date of Patent: January 10, 2023
    Assignee: MASSACHUSETTS EYE AND EAR INFIRMARY
    Inventors: James Anthony Stefater, III, Tomasz Pawel Stryjewski
  • Patent number: 11541072
    Abstract: Editing of VEGFR2 abrogated angiogenesis in two mouse models of oxygen-induced retinopathy (OIR) and laser-induced choroid neovascularization (CNV). Provided are compositions, e.g., Adeno-Associated Virus (AAV) Vectors comprising sequences encoding CRISPR/Cas9 proteins and guide RNA, and methods of use thereof for editing of Vascular endothelial growth factor receptor 2 (VEGFR2) gene to treat ocular disease associated with pathological angiogenesis, e.g., neovascular age-related macular degeneration (AMD), proliferative diabetic retinopathy (PDR) and retinopathy of prematurity (ROP).
    Type: Grant
    Filed: June 27, 2018
    Date of Patent: January 3, 2023
    Assignee: Massachusetts Eye and Ear Infirmary
    Inventor: Hetian Lei
  • Patent number: 11542472
    Abstract: Methods for generating cells of the inner ear, e.g., hair cells and supporting cells, from stem cells, e.g., mesenchymal stem cells, are provided, as well as compositions including the inner ear cells. Methods for the therapeutic use of the inner ear cells for the treatment of hearing loss are also described.
    Type: Grant
    Filed: November 8, 2019
    Date of Patent: January 3, 2023
    Assignee: Massachusetts Eye & Ear Infirmary
    Inventor: Albert Edge
  • Patent number: 11480740
    Abstract: The present disclosure relates to optical fiber coupling systems and methods of coupling optical fibers across and with a magnetic field.
    Type: Grant
    Filed: December 4, 2018
    Date of Patent: October 25, 2022
    Assignee: Massachusetts Eye and Ear Infirmary
    Inventor: Eleftherios Ilios Paschalis
  • Patent number: 11466252
    Abstract: This disclosure relates to methods for expanding inner ear supporting cells (e.g., Lgr5+ inner ear supporting cells) and differentiating inner ear supporting cells (e.g., Lgr5+ inner ear supporting cells) to inner ear hair cells (e.g., atonal homolog 1 (Atoh1)+ inner ear hair cells) and the use of the inner hear supporting cells and hair cells, e.g., for identifying candidate therapeutic compounds for the treatment of hearing loss and balance loss. Additionally, the methods described herein can be used in the treatment of a subject having hearing loss and balance loss that would benefit from increased proliferation and differentiation of inner ear supporting cells (e.g., Lgr5+ inner ear supporting cells).
    Type: Grant
    Filed: January 27, 2017
    Date of Patent: October 11, 2022
    Assignees: Massachusetts Eye and Ear Infirmary, Decibel Therapeutics, Inc.
    Inventors: Albert Edge, Michael Venuti, Agnieszka Czechowicz
  • Patent number: 11466258
    Abstract: Methods are described for predicting ancestral sequences for viruses or portions thereof. Also described are predicted ancestral sequences for adeno-associated virus (AAV) capsid polypeptides. The disclosure also provides methods of gene transfer and methods of vaccinating subjects by administering a target antigen operably linked to the AAV capsid polypeptides.
    Type: Grant
    Filed: June 19, 2020
    Date of Patent: October 11, 2022
    Assignees: The Schepens Eye Research Institute, Inc., Massachusetts Eye and Ear Infirmary
    Inventors: Luk H. Vandenberghe, Eric Zinn
  • Publication number: 20220315948
    Abstract: Aspects of the disclosure relate to compositions, nucleic acids, vectors, viruses, and methods useful for treating hearing loss and/or blindness, for example, Usher Syndrome type IF. The present disclosure provides isolated nucleic acids, vectors, and rAAV.9.PHP.B comprising a transgene encoding a mini-PCDH15, and methods of treating hearing loss using the same. The present disclosure also provides a gRNA associated with a base editor to correct one or more mutations in PCDH15 for treating hearing loss and/or vision loss.
    Type: Application
    Filed: April 24, 2020
    Publication date: October 6, 2022
    Applicants: President and Fellows of Harvard College, Ohio State Innovation Foundation, Massachusetts Eye and Ear Infirmary
    Inventors: David P. Corey, Artur Indzhykulian, Marcos Sotomayor, Maryna V. lvanchenko, Cole W. D. Peters
  • Patent number: 11408900
    Abstract: Methods for identifying and optionally treating subjects, e.g., subjects who have Chronic Rhinosinusitis (CRS), based on the detection of elevated levels of soluble P-glycoprotein in nasal secretions. The methods of treatment can include administration of a therapeutically effective amount of a P-glycoprotein inhibitor.
    Type: Grant
    Filed: January 13, 2017
    Date of Patent: August 9, 2022
    Assignee: Massachusetts Eye and Ear Infirmary
    Inventors: Benjamin S. Bleier, Angela Nocera
  • Patent number: 11395606
    Abstract: Non-invasive methods of detecting hidden hearing loss (cochlear synaptopathy) based on detection of an abnormal ratio of Summating Potential (SP)/Action Potential (AP) (SP/AP) Ratios.
    Type: Grant
    Filed: January 20, 2017
    Date of Patent: July 26, 2022
    Assignee: Massachusetts Eye and Ear Infirmary
    Inventors: M. Charles Liberman, Stephane Maison
  • Patent number: 11370823
    Abstract: Compositions and provided to induce cells of the inner ear to renter the cell cycle and to proliferate. In particular, hair cells are induced to proliferate by administration of a composition which activates the Myc and Notch. Supporting cells are induced to transdifferentiate to hair cells by inhibition of Myc and Notch activity or the activation of Atoh1. Methods of treatment include the intracellular delivery of these molecules to a specific therapeutic target.
    Type: Grant
    Filed: October 29, 2015
    Date of Patent: June 28, 2022
    Assignees: Massachusetts Eye and Ear Infirmary, President and Fellows of Harvard College
    Inventors: Zheng-Yi Chen, David R. Liu, Margie Li, David B. Thompson, John Zuris
  • Patent number: 11350820
    Abstract: The technology described in this document can be embodied in systems and computer-implemented methods for determining a score representing an amount of staining of the cornea. The methods include obtaining a digital image of the cornea stained with a tracer material, receiving a selection of a portion of the image, and processing, by a processing device, the selection to exclude areas with one or more artifacts to define an evaluation area. For each of a plurality of pixels within the evaluation area, a plurality of Cartesian color components are determined and a hue value in a polar coordinate based color space is calculated from the components. An amount of staining of the cornea is then determined as a function of the hue value. The methods also include assigning a score to the evaluation area based on the amount of staining calculated for the plurality of pixels.
    Type: Grant
    Filed: December 2, 2019
    Date of Patent: June 7, 2022
    Assignee: Massachusetts Eye and Ear Infirmary
    Inventors: Reza Dana, Francisco L. Amparo Pulido, Haobing Wang
  • Patent number: 11331391
    Abstract: This invention relates to drug conjugates useful for localized treatment of diseases or disorders of the middle ear and/or inner ear. Methods of treating diseases or disorders of the middle ear and/or inner ear, pharmaceutical compositions comprising the conjugates, and methods of inhibiting a Tropomyosin receptor kinase are also provided.
    Type: Grant
    Filed: January 25, 2017
    Date of Patent: May 17, 2022
    Assignees: Massachusetts Eye and Ear Infirmary, University of Southern California
    Inventors: Charles E. McKenna, Boris A. Kashemirov, Shuting Sun, Kim Nguyen, David Jung, Michael J. McKenna, William Sewell, Judith Kempfle, Woo Seok Kang, Albert Edge
  • Patent number: 11331295
    Abstract: Methods of using a high-dose statin for treatment of AMD in a patient can be used to regress drusen and/or drusenoid pigment epithelial detachments (PEDs), to prevent atrophy of the RPE and/or one or more photoreceptors, to prevent vision loss and/or improve visual acuity, and/or to prevent progression from dry AMD to wet AMD.
    Type: Grant
    Filed: October 14, 2016
    Date of Patent: May 17, 2022
    Assignee: MASSACHUSETTS EYE AND EAR INFIRMARY
    Inventors: Demetrios Vavvas, Joan W Miller
  • Publication number: 20220133956
    Abstract: The invention provides methods and polymer compositions for treating retinal detachment and other ocular disorders, where the methods employ polymer compositions that can form a hydrogel in the eye of a subject. The hydrogel is formed by reaction of (i) a nucleo-functional polymer that is a biocompatible polymer containing a plurality of thio-functional groups —R1-SH wherein R1 is an ester-containing linker, such as a thiolated poly(vinyl alcohol) polymer and (ii) an electro-functional polymer that is a biocompatible polymer containing at least one thiol-reactive group, such as a poly(ethylene glycol) polymer containing alpha-beta unsaturated ester groups.
    Type: Application
    Filed: January 13, 2022
    Publication date: May 5, 2022
    Applicant: Massachusetts Eye and Ear Infirmary
    Inventors: James Anthony STEFATER, III, Tomasz Pawel STRYJEWSKI
  • Patent number: 11298328
    Abstract: The present disclosure provides compositions and methods for treating subjects at risk for or with sensorineural hearing loss. Such compositions and methods include modulating the epigenetic status of the cell, or rate of protein degradation, to increase expression and/or levels of Atoh1 protein.
    Type: Grant
    Filed: March 9, 2020
    Date of Patent: April 12, 2022
    Assignee: Massachusetts Eye and Ear Infirmary
    Inventors: Albert Edge, Judith Kempfle, Dunia Abdul-Aziz
  • Patent number: 11298018
    Abstract: The present application includes methods, systems and computer readable storage devices for determining a color score for at least a portion of a biological tissue. The subject matter of the application is embodied in a method that includes obtaining a digital image of the biological tissue, and receiving a selection of a portion of the image as an evaluation area. The method also includes determining for each of a plurality of pixels within the evaluation area, a plurality of color components that are based on a Cartesian color space, and determining, from the color components, a hue value in a polar coordinate based color space. The method further includes determining a color value based on the hue value for each of the plurality of pixels, and assigning a color score to the evaluation area based on an average of the color values of the plurality of pixels.
    Type: Grant
    Filed: December 18, 2019
    Date of Patent: April 12, 2022
    Assignee: Massachusetts Eye and Ear Infirmary
    Inventors: Reza Dana, Francisco L. Amparo Pulido, Haobing Wang
  • Patent number: 11286487
    Abstract: The present disclosure provides compositions and methods for treating subjects at risk for or with sensorineural hearing loss by modulating the rate of Atoh1 protein degradation to increase levels of Atoh1 protein.
    Type: Grant
    Filed: March 19, 2019
    Date of Patent: March 29, 2022
    Assignee: Massachusetts Eye and Ear Infirmary
    Inventors: Albert Edge, Yen-Fu Cheng, Judith Kempfle, Dunia Abdul-Aziz
  • Patent number: 11229726
    Abstract: In some embodiments, the present invention provides methods for making resorbable ear tubes including the steps of providing a silk fibroin solution, and forming a silk ear tube from the silk fibroin solution, wherein the silk ear tube is less than 2 mm in length and has an outer diameter of less than 1.5 mm, and wherein the silk ear tube is resorbable. In some embodiments, the present invention also provides methods for treating otitis media including the step of introducing a silk ear tube into the ear canal of a subject, wherein the silk ear tube is less than 2 mm in length and has an outer diameter of less than 1.5 mm, and wherein the silk ear tube is resorbed by the subject.
    Type: Grant
    Filed: April 1, 2021
    Date of Patent: January 25, 2022
    Assignees: Tufts University, Massachusetts Eye and Ear Infirmary, The General Hospital Corporation
    Inventors: David Kaplan, Michael Whalen, Christopher Hartnick
  • Patent number: 11185536
    Abstract: Methods for treating hearing loss that include administering an inhibitor, e.g., a small molecule inhibitor, of casein kinase 1, preferably in combination with a treatment that stimulates Atoh1 gene expression, e.g., a gamma-secretase inhibitor, an Atoh1 stimulatory compound, or a GSK-3-beta inhibitor.
    Type: Grant
    Filed: December 2, 2016
    Date of Patent: November 30, 2021
    Assignee: Massachusetts Eye and Ear Infirmary
    Inventors: Albert Edge, Yenfu Cheng