Patents Assigned to Massachusetts General Hospital Corporation
  • Patent number: 10197646
    Abstract: A magnetic resonance imaging (MRI) system includes a plurality of transmitters to generate a parallel transmission radio frequency (RF) pulse, an array of coils coupled to the plurality of transmitters to apply the parallel transmission RF pulse to a subject, and a decoupling system connected to the plurality of transmitters and the array of coils. The decoupling system includes a plurality of hybrid couplers, each hybrid coupler of the plurality of hybrid couplers being coupled to a respective pair of the plurality of transmitters and to a respective pair of the array of coils. The plurality of hybrid couplers are configured to diagonalize an impedance matrix of the plurality of coils.
    Type: Grant
    Filed: May 6, 2015
    Date of Patent: February 5, 2019
    Assignees: Siemens Aktiengesellschaft, Massachusetts Institute of Technology, Massachusetts General Hospital Corporation
    Inventors: Elfar Adalsteinsson, Luca Daniel, Bastien Guerin, Boris Keil, Zohaib Mahmood, Markus Vester, Lawrence Wald
  • Patent number: 9636039
    Abstract: In a magnetic resonance (MR) imaging method and apparatus, multiple diagnostic scans are obtained of an examination subject during an imaging session. An initial reference scan of the subject is obtained at the beginning of the session and, as the session proceeds, an automatic determination is made before each diagnostic scan is obtained as to whether the immediately preceding reference scan is still valid, primarily be checking whether an amount of patient movement has occurred that renders the immediately preceding reference scan invalid. Either a new reference scan is obtained before the next diagnostic scan, or, if still valid, the immediately preceding reference scan is used for the next diagnostic scan.
    Type: Grant
    Filed: August 7, 2014
    Date of Patent: May 2, 2017
    Assignees: Siemens Aktiengesellschaft, Massachusetts General Hospital Corporation
    Inventors: Thomas Benner, Andre Jan Willem Van Der Kouwe
  • Publication number: 20160038054
    Abstract: In a magnetic resonance (MR) imaging method and apparatus, multiple diagnostic scans are obtained of an examination subject during an imaging session. An initial reference scan of the subject is obtained at the beginning of the session and, as the session proceeds, an automatic determination is made before each diagnostic scan is obtained as to whether the immediately preceding reference scan is still valid, primarily be checking whether an amount of patient movement has occurred that renders the immediately preceding reference scan invalid. Either a new reference scan is obtained before the next diagnostic scan, or, if still valid, the immediately preceding reference scan is used for the next diagnostic scan.
    Type: Application
    Filed: August 7, 2014
    Publication date: February 11, 2016
    Applicants: MASSACHUSETTS GENERAL HOSPITAL CORPORATION, SIEMENS AKTIENGESELLSCHAFT
    Inventors: Thomas Benner, Andre Jan Willem Van Der Kouwe
  • Patent number: 9041396
    Abstract: In a method for calculating a B0 field map (a map of the basic magnetic field) in a magnetic resonance apparatus, a navigator pulse is emitted and navigator response resulting from the navigator pulse are detected in at least some channels of a multichannel RF coil array. Each channel of the multichannel RF coil array includes an RF coil and spatial information regarding the respective positions of the individual RF coils is made available to a processor, together with the multiple navigator signals. Using the spatial information obtained from the position of the RF coils that respectively detected the navigator response signals, a B0 field map is generated, without the need for spatial encoding the respective navigator response signals.
    Type: Grant
    Filed: January 23, 2012
    Date of Patent: May 26, 2015
    Assignees: Siemens Aktiengesellschaft, Massachusetts General Hospital Corporation
    Inventors: Josef Pfeuffer, Lawrence Wald
  • Patent number: 8349832
    Abstract: The invention relates to compounds and composition for the treatment and prevention of cancer. The invention also covers all diseases that may be treated by selective modulation of levels of reactive oxygen species in diseased cells versus normal cells. Methods for the preparation and administration of such compositions are also disclosed.
    Type: Grant
    Filed: September 2, 2010
    Date of Patent: January 8, 2013
    Assignees: Canthera Therapeutics, The Massachusetts General Hospital Corporation
    Inventors: Michael Andrew Foley, Robert Gould, Peter Elliott, Anna Mandinova
  • Publication number: 20090265001
    Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.
    Type: Application
    Filed: May 12, 2009
    Publication date: October 22, 2009
    Applicants: Massachusetts General Hospital Corporation, Cambridge Polymer Group, Inc.
    Inventors: Orhun K. Muratoglu, Stephen H. Spiegelberg
  • Patent number: 6262248
    Abstract: Disclosed is substantially pure DNA encoding an Arabidopsis thaliana Rps2 polypeptide; substantially pure Rps2 polypeptide; and methods of using such DNA to express the Rps2 polypeptide in plant cells and whole plants to provide, in transgenic plants, disease resistance to pathogens. Also disclosed are conserved regions characteristic of the RPS family and primers and probes for the identification and isolation of additional RPS disease-resistance genes.
    Type: Grant
    Filed: April 28, 1999
    Date of Patent: July 17, 2001
    Assignees: Massachusetts General Hospital Corporation, The United States of America as represented by the Secretary of Agriculture, Commonwealth Scientific and Industrial Research Organization, The Regents of the University of California
    Inventors: Frederick M. Ausubel, Brian J. Staskawicz, Andrew F. Bent, Douglas Dahlbeck, Fumiaki Katagiri, Barbara N. Kunkel, Michael Nicholas Mindrinos, Guo-Liang Yu, Barbara Baker, Jeffrey Ellis, John Salmeron
  • Patent number: 4480920
    Abstract: Method and apparatus for producing a fringe pattern corresponding to height and depth gradients of an illuminated object with the fringe pattern lines used to define edges of stacked sheets provided as a filter for X-ray dosage tailoring. A camera is provided to produce the fringe pattern on a photographic film using a compact arrangement of light sources, lenses and gratings all within a convenient housing facilitating use yet at the same time providing sufficient resolution through separation of projection and imaging optics. A laser range finder is additionally provided to insure placement of the object to be X-rayed, typically a portion of the human torso, at a standard distance so that the ultimately produced X-ray filter will be properly sized. The filter is produced by cutting a set of lead sheets with edges corresponding to each of the separate contour lines in the exposed and developed film receiving the fringe pattern.
    Type: Grant
    Filed: August 2, 1983
    Date of Patent: November 6, 1984
    Assignee: The Massachusetts General Hospital Corporation
    Inventors: Arthur L. Boyer, Michael Goitein