Abstract: A method of treating a subject having unwanted cell proliferation which includes: inducing differentiation in a cell; providing said cell with a photosensitizer; and activating said PS, thereby the treating unwanted cell proliferation.
Type:
Application
Filed:
December 21, 2007
Publication date:
December 18, 2008
Applicant:
Massachusetts General Hospital, Partners HealthCare Research Ventures & Licensing
Abstract: Described are methods for protecting the female reproductive system against natural and artificial insults by administering to women a composition comprising an agent that antagonizes one or more acid sphingomyelinase (ASMase) gene products. Specifically, methods disclosed herein serve to protect women's germline from damage resulting from cancer therapy regimens including chemotherapy or radiotherapy. In one aspect, the method preserves, enhances, or revives ovarian function in women, by administering to women a composition containing sphingosine-1-phosphate, or an analog thereof. Also disclosed are methods to prevent or ameliorate menopausal syndromes and to improve in vitro fertilization techniques.
Type:
Application
Filed:
March 7, 2007
Publication date:
July 5, 2007
Applicant:
Massachusetts General Hospital, Partners HealthCare Research Ventures & Licensing