Patents Assigned to Massachusetts General Hospital
  • METHOD FOR SELECTING A CANCER THERAPY
    Publication number: 20130005747
    Abstract: The present invention provides a method for determining whether or not a cancer subject is suitable for treatment with a purine-based roscovitine-like inhibitor, which method comprises the step of determining the ras status of the cancer, wherein a determination that the subject has mutant ras status is indicative that the subject is suitable for treatment with a purine-based roscovitine-like inhibitor.
    Type: Application
    Filed: December 21, 2011
    Publication date: January 3, 2013
    Applicants: Cyclacel Limited, The General Hospital Corporation d/b/a Massachusetts General Hospital, The Trustees of Dartmouth College
    Inventors: Simon Richard GREEN, Judy H. CHIAO, Jeffery SETTLEMAN, Ethan DMITROVSKY, Fabrizio Vittorio GALIMBERTI
  • SINGLE-DOSE SYRINGE DRIVER
    Publication number: 20120330236
    Abstract: Various methods and devices for driving fluid from a syringe are provided. In one exemplary embodiment, a luer fitting for connecting a syringe barrel to a syringe driver is provided that includes a proximal female end including a socket adapted to be removably mated to a male luer fitting on the syringe barrel. The luer fitting further includes a distal end including a nozzle adapted to receive a fluid conduit. The distal end has a non-threaded axially-oriented annular socket formed therein for removably receiving a protrusion on the syringe driver.
    Type: Application
    Filed: July 27, 2012
    Publication date: December 27, 2012
    Applicant: THE GENERAL HOSPITAL CORPORATION d/b/a MASSACHUSETTS GENERAL HOSPITAL
    Inventors: Nathaniel M. Sims, Michael H. Wollowitz
  • IMPLANT FOR RESTORING NORMAL RANGE FLEXION AND KINEMATICS OF THE KNEE
    Publication number: 20120310362
    Abstract: Embodiments of the invention provide knee prostheses which more faithfully and closely replicate the function, anatomy and physiology of the normal human knee yielding a number of advantages. Among other things, such prostheses can provide an increased range of motion and function more normally particularly in extension, deep flexion and during normal gait. Knee prostheses according to various aspects of the invention recognize that during movement of the knee, particularly during flexion, the kinematics of the bones of the knee are a result of achieving equilibrium of the forces that cause motion of the knee. In addition, the shape of the articular surfaces acting in combination with forces imposed by various muscles, ligaments and tendons, determines the direction of the large contact forces.
    Type: Application
    Filed: June 7, 2012
    Publication date: December 6, 2012
    Applicant: The General Hospital Corporation D/B/A Massachusetts General Hospital
    Inventors: Guoan Li, Harry E. Rubash, Kartik Mangudi Varadarajan
  • TOPICAL AMINOLEVULINIC ACID-PHOTODYNAMIC THERAPY FOR THE TREATMENT OF ACNE VULGARIS
    Publication number: 20120296263
    Abstract: Light treatments of sebaceous gland disorders with 5-aminolevulinic acid and photodynamic therapy are disclosed. A preferred treatment includes topical application of 5-aminolevulinic acid to the skin followed by light exposures with repeated treatment at various intervals. At low doses of ALA and photodynamic therapy (PDT) in single or multiple treatments, improvement in the sebaceous gland disorder, e.g., acne, provides the discovery that diminishment in sebum secretion and the eradication of bacteria occurs. At high doses of ALA and a single high energy PDT treatment, permanent changes to the sebaceous gland and sebum secretion have been discovered.
    Type: Application
    Filed: August 3, 2012
    Publication date: November 22, 2012
    Applicant: The General Hospital Corporation D/B/A Massachusetts General Hospital
    Inventor: Richard Rox ANDERSON
  • METHODS AND COMPOSITIONS RELATING TO NEURONAL CELL AND TISSUE DIFFERENTIATION
    Publication number: 20120251506
    Abstract: The invention relates to methods for isolating and purifying specific types of neurons, such as cortical or other projection neurons including corticospinal motor neurons, subcerebral projection neurons, and callosal projection neurons. The invention also relates to genes that are specific for particular neuronal subtypes, and the use of such genes in genetic/molecular control of cell development. The isolated cells and subtype-specific genes also have uses in diagnostics, therapeutics, and screening assays for pharmaceutical molecules.
    Type: Application
    Filed: May 18, 2012
    Publication date: October 4, 2012
    Applicant: The General Hospital Corporation d/b/a Massachusetts General Hospital
    Inventors: Jeffrey D. Macklis, Paola Arlotta, Bradley J. Molyneaux
  • COMPOSITIONS, METHODS, AND DEVICES FOR TREATING LIVER DISEASE
    Publication number: 20120225130
    Abstract: Described are compositions and methods for treating liver disease, e.g., acute liver disease, using bone marrow-derived stem cells and bone marrow-derived stem cell conditioned media.
    Type: Application
    Filed: April 30, 2012
    Publication date: September 6, 2012
    Applicants: Massachusetts Institute of Technology, The General Hospital Corporation d/b/a massachusetts General Hospital
    Inventors: Martin L. Yarmush, Biju Parekkadan
  • METHODS FOR MAKING OXIDATION RESISTANT POLYMERIC MATERIAL
    Publication number: 20120215321
    Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.
    Type: Application
    Filed: April 23, 2012
    Publication date: August 23, 2012
    Applicants: Cambridge Polymer Group, Inc., The General Hospital Corporation dba Massachusetts General Hospital
    Inventors: Orhun K. Muratoglu, Stephen H. Spiegelberg
  • INHIBITING INFLAMMATION WITH MILK OLIGOSACCHARIDES
    Publication number: 20120202753
    Abstract: A method of inhibiting inflammation in a subject comprising the administration of milk oligosaccharides or glycoconjugates containing milk oligosaccharides is disclosed.
    Type: Application
    Filed: July 2, 2010
    Publication date: August 9, 2012
    Applicants: Instituto Nacional de Ciencias Medicas Y Nutricion, The General Hospital Corporation d/b/a Massachusetts General Hospital, (CCHMC)
    Inventors: Ardythe L. Morrow, David S. Newburg, Guillermo M. Ruiz-Palacios
  • METHODS AND DEVICES FOR THE SUSTAINED RELEASE OF MULTIPLE DRUGS
    Publication number: 20120202742
    Abstract: The invention relates to an drug delivery device and a method for delivering multiple drugs over a prolonged period of time. The drug delivery device has two or more unitary segments comprising a drug-permeable polymeric substance, wherein at least one of the segments further comprises a pharmaceutically active agent. The invention also relates to a method for the treatment of a benign ovarian secretory disorder in a female mammal, a method of contraception, and a method of relieving the symptoms associated with menopausal, perimenopausal and post-menopausal periods in a woman.
    Type: Application
    Filed: January 14, 2011
    Publication date: August 9, 2012
    Applicants: Massachusetts Institute of Technology, The General Hospital Corporation D/B/A Massachusetts General Hospital
    Inventors: Eyal S. Ron, Robert S. Langer, William F. Crowley, JR.
  • PERIPHERAL BLOOD SAMPLING METHODS AND DEVICES
    Publication number: 20120191010
    Abstract: Methods and devices are provided for transporting fluid between a body and an external source. More particularly, the methods and devices provided can be used to transport blood from a body. In one exemplary embodiment, a system is provided for transporting fluid between a body and an external source. The system can include a collection catheter that is sized to fit inside a catheter that is placed in the body and configured to have its distal end extend beyond a distal end of the catheter that is placed in the body. Various methods for transporting fluid from the body to an external source are also provided.
    Type: Application
    Filed: July 20, 2010
    Publication date: July 26, 2012
    Applicant: THE GENERAL HOSPITAL CORPORATION D/B/A MASSACHUSETTS GENERAL HOSPITAL
    Inventor: Michael S. Cabot
  • HEMATOPOIETIC STROMAL PROGENITOR CELLS AND USES THEREOF
    Publication number: 20120177618
    Abstract: The invention provides compositions and methods for modulating disease using hematopoietic stromal progenitor cells derived from hematopoietic tissues. The invention further provides methods for isolating, storing and culturing hematopoietic stromal progenitor cells.
    Type: Application
    Filed: July 14, 2010
    Publication date: July 12, 2012
    Applicants: Massachusetts Institute of Technology, The General Hospital Corporation d/b/a Massachusetts General Hospital
    Inventors: Biju Parekkadan, John Miles Milwid, Martin Leon Yarmush
  • Compositions And Methods For Assessing Cytotoxicity Of Single Cells
    Publication number: 20120149592
    Abstract: The invention provides a method of analyzing interactions between pairs of target and effector cells utilizing high-throughput screenings methods for profiling large numbers of single cells in microarrays.
    Type: Application
    Filed: July 13, 2009
    Publication date: June 14, 2012
    Applicant: The General Hospital Corporation d/b/a Massachusetts General Hospital
    Inventors: J. Christopher Love, Bruce Walker, Navin Varadarajan, Boris Julg
  • Retinal Flow Cytometry
    Publication number: 20120136258
    Abstract: The present invention provides methods and devices for performing flow cytometry. In one embodiment, blood circulating through one or more retinal blood vessels of a subject is illuminated in-vivo so as to excite a plurality of fluorescent-labeled cells contained in the blood. The fluorescence radiation emitted by the excited cells is then detected and analyzed to count the cells from which fluorescence is detected.
    Type: Application
    Filed: January 25, 2012
    Publication date: May 31, 2012
    Applicant: The General Hospital Corporation D/B/A Massachusetts General Hospital
    Inventors: Charles P. Lin, Clemens Alt, Israel Veilleux, Daniel Cote
  • METHODS AND COMPOSITIONS FOR IMPROVING THE VIABILITY OF CRYOPRESERVED CELLS
    Publication number: 20120128641
    Abstract: The present invention provides polymers and methods for increasing the viability of cryopreserved cells after thawing. Thawing cryopreserved cells in the presence of a polymer such as poloxymer P1 88 or other non-ionic polymers is thought to stabilize the membranes of the cells leading to increased post-thaw viability. Such methods may be used in the processing of cells and tissues for transplantation or for research purposes. Other agents such as antioxidants, vitamins, or osmotic protectants may also be added to cells to improve viability.
    Type: Application
    Filed: July 20, 2010
    Publication date: May 24, 2012
    Applicant: The General Hospital Corporation d/b/a Massachusetts General Hospital
    Inventor: William G. Austen, JR.
  • ANTIBODIES TO CROSS-LINKED AMYLOID BETA OLIGOMERS
    Publication number: 20120114635
    Abstract: The invention relates to antibodies that bind cross-linked amyloid ? oligomers, and methods for using such antibodies for diagnosis and treatment of Alzheimer's disease.
    Type: Application
    Filed: June 7, 2011
    Publication date: May 10, 2012
    Applicant: The General Hospital Corporation d/b/a Massachusetts General Hospital
    Inventors: Robert Moir, Rudolph E. Tanzi
  • INHIBITION OF HDAC2 TO PROMOTE MEMORY
    Publication number: 20120101147
    Abstract: The invention relates to methods and products for enhancing and improving recovery of lost memories. In particular the methods are accomplished by inhibiting HDAC2 and or selectively inhibiting HDAC1/2 or HDAC1/2/3.
    Type: Application
    Filed: December 2, 2009
    Publication date: April 26, 2012
    Applicant: The General Hospital Corporation d/b/a Massachusetts General Hospital
    Inventors: Li-Huei Tsai, Andre Fischer, Stephen J. Haggarty, Weiping Tang, Stuart L. Schreiber, Edward Holson, Florence Wagner, Mikel P. Moyer
  • HEADS FOR DERMATOLOGY TREATMENT
    Publication number: 20120083862
    Abstract: Methods and apparatus for dermatology treatment are provided which involve the use of continuous wave (CW) radiation, preheating of the treatment volume, precooling, cooling during treatment and post-treatment cooling of the epidermis above the treatment volume, various beam focusing techniques to reduce scattering and/or other techniques for reducing the cost and/or increasing the efficacy of optical radiation for use in hair removal and other dermatological treatments. A number of embodiments are included for achieving the various objectives indicated above.
    Type: Application
    Filed: December 12, 2011
    Publication date: April 5, 2012
    Applicants: The General Hospital Corporation, D/B/A Massachusetts General Hospital, PALOMAR MEDICAL TECHNOLGIES
    Inventors: Gregory B. Altshuler, R. Rox Anderson
  • NOVEL LIPOXYGENASE INHIBITORS AS NEUROPROTECTIVE AGENTS
    Publication number: 20120053220
    Abstract: The present invention relates to the identification of inhibitors of lipoxygenase enzymes. Methods are presented for using novel lipoxygenase inhibitors: LOXBlock-1 and LOXBlock-3, and other candidate lipoxygenase inhibitors identified by similar screening strategies, in therapy and diagnostics for neurodegenerative disorders.
    Type: Application
    Filed: August 1, 2008
    Publication date: March 1, 2012
    Applicants: The General Hospital Corporation d/b/a Massachusetts General Hospital, Florey Neuroscience Institutes, The Regents of the University of California
    Inventors: Klaus Van Leyen, Theodore R. Holman, Eng H. Lo, Matthew P. Jacobson, David W. Howells
  • FUS/TLS-BASED COMPOUNDS AND METHODS FOR DIAGNOSIS, TREATMENT AND PREVENTION OF AMYOTROPHIC LATERAL SCLEROSIS AND RELATED MOTOR NEURON DISEASES
    Publication number: 20120046341
    Abstract: The invention provides novel FUS/TLS nucleic acids and proteins that comprise one or more genetic markers (for example, single nucleotide polymorphisms) and methods of use thereof including methods relating to the diagnosis of ALS or other related motor neuron disease by virtue of the presence of the mutant FUS/TLS sequence(s).
    Type: Application
    Filed: July 21, 2009
    Publication date: February 23, 2012
    Applicant: The General Hospital Corporation d/b/a Massachusetts General Hospital
    Inventors: Thomas J. Kwiatkowski, JR., Robert H. Brown, JR.
  • EPIGENETIC MECHANISMS RE-ESTABLISH ACCESS TO LONG-TERM MEMORY AFTER NEURONAL LOSS
    Publication number: 20120039909
    Abstract: The invention relates to methods and products for enhancing and improving recovery of lost memories. In particular the methods are accomplished through the increase of histone acetylation.
    Type: Application
    Filed: October 24, 2011
    Publication date: February 16, 2012
    Applicants: The General Hospital Corporation d/b/a Massachusetts General Hospital, Massachusetts Institute of Technology, President and Fellows of Harvard College
    Inventors: Li-Huei Tsai, Andre Fischer, Stephen Haggarty, Weiping Tang, Stuart L. Schreiber