Patents Assigned to Massachusetts Insitiute of Technology
  • Transdermal delivery of encapsulated drugs
    Patent number: 5814599
    Abstract: Applications of low-frequency (20 KHz) ultrasound enhances transdermal transport of high-molecular weight proteins. This method includes a simultaneous application of ultrasound and protein on the skin surface in order to deliver therapeutic doses of proteins across the skin. Examples demonstrate in vitro and in vivo administration of insulin (molecular weight 6,000 D), and in vitro administration of gamma interferon (molecular weight 17,000 D), and erythropoeitin (molecular weight 48,000 D).
    Type: Grant
    Filed: August 4, 1995
    Date of Patent: September 29, 1998
    Assignee: Massachusetts Insitiute of Technology
    Inventors: Samir S. Mitragotri, Daniel Blankschtein, Robert S. Langer