Abstract: Methods, compositions, kits, and drug delivery devices are provided for treating, adhering, or sealing biological tissues. The methods include combining a first solution that includes an oligomer/polymer component and a second solution that includes a dendrimer component, and at least one of the oligomer/polymer component and dendrimer component includes at least one substituent that is capable of photoreversible dimerization. The reversible dimerization of the substituent may allow for the reversible dimerization and/or polymerization of one or more components. The substituent that is capable of photoreversible dimerization may be active by the application of light, such as UV light.
Type:
Grant
Filed:
June 23, 2016
Date of Patent:
September 22, 2020
Assignee:
Massachusetts Instiitute of Technology
Inventors:
Natalie Artzi, Elazer R. Edelman, Regina Kelmansky, Marc Mier Cervantes, Yi Zhang