Patents Assigned to MASSACHUSETTS INSTITUTE OF TECHNOLOGIES
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Publication number: 20240164432Abstract: Compositions configured to interact with organic molecules, and related articles and methods, are generally described.Type: ApplicationFiled: November 4, 2022Publication date: May 23, 2024Applicant: Massachusetts Institute of TechnologyInventors: Timothy Manning Swager, Ruqiang Lu
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Publication number: 20240167874Abstract: Fabry-Pérot filters having different cavity thicknesses are formed in arrays on a substrate for spectral sensing. The filter array can be coupled to a detector array to make a compact, low size, weight and power spectral sensor that detects spectral information in a scene viewed by the detector array. The spectral sensor can be used in a compact spectrometer to detect the presence of harmful chemical vapors.Type: ApplicationFiled: January 25, 2023Publication date: May 23, 2024Applicant: Massachusetts Institute of TechnologyInventor: William Lawrence
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Patent number: 11988471Abstract: Devices and methods for fabrication of a multiscale porous high-temperature heat exchanger for high-temperature and high-pressure applications are disclosed. The heat exchanger can include a core with macrochannels formed in a checkerboard pattern to facilitate alternative flow of working fluid having hot and cold temperatures between adjacent macrochannels. Each macrochannel can include a two-dimensional microchannel array that further distributes flow throughout the heat exchanger to enhance heat transfer and mechanical strength without significant pressure drop penalty. The heat exchanger can further include a header integrated therewith to distribute working fluid flowing through the heat exchanger through the outlets such that it flows evenly therethrough. Methods of fabricating heat exchangers of this nature are also disclosed.Type: GrantFiled: March 28, 2022Date of Patent: May 21, 2024Assignees: Massachusetts Institute of Technology, Purdue Research FoundationInventors: Evelyn N. Wang, Lin Zhao, Bikram Bhatia, Xiangyu Li, Arny Leroy, Kyle Wilke, Lenan Zhang, Jeffrey Youngblood, Rodney Trice, Chad T. Wilson, Olivia Brandt, Rodrigo Orta Guerra
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Patent number: 11988938Abstract: An optical modulator is disclosed that includes an optical resonator structure. The optical resonator structure includes at least one non-linear portion, the at least one non-linear portion comprising at least one radial junction region. The at least one radial junction region is formed between at least first and second materials, respectively, having different electronic conductivity characteristics. A principal axis of the at least one radial junction region is oriented along a radius of curvature of the at least one non-linear portion. The optical modulator includes an optical waveguide that is coupled to the at least one non-linear portion of the optical resonator structure.Type: GrantFiled: April 26, 2021Date of Patent: May 21, 2024Assignees: Massachusetts Institute of Technology, University of ColoradoInventors: Milos A. Popovic, Jeffrey Michael Shainline, Jason Orcutt, Vladimir Marko Stojanovic
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Patent number: 11990607Abstract: A hybrid cathode for a Li—S battery may include an intercalation-type material and a conversion-type material. The conversion-type material, such as sulfur, may increase the gravimetric energy density, Eg, of the battery. The intercalation-type material may increase the electrical and ionic conductivity of the cathode and contribute to the capacity of the battery, enabling replacement of partial high-surface-area conductive carbon and increasing the volumetric energy density, Ev. In combination, the conversion-type material and the intercalation-type material may be used to increase Eg and Ev simultaneously while providing sufficient rate capability. In one example, a hybrid cathode includes an electrode and a cathode material. The cathode material includes a first concentration of an intercalation compound, a second concentration of sulfur, and a third concentration of carbon. Furthermore, the intercalation compound and sulfur contribute to the capacity of the Li—S battery within a voltage window of 1.Type: GrantFiled: April 22, 2019Date of Patent: May 21, 2024Assignee: Massachusetts Institute of TechnologyInventors: Weijiang Xue, Liumin Suo, Ju Li
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Patent number: 11987790Abstract: Embodiments disclosed herein provide a general, scalable, high-throughput, and high-resolution approach for experimental dissection of regulatory regions and driver nucleotides in the context of human biology and disease. Applicants present HiDRA, a novel high-resolution global screen for transcriptional regulatory activity in accessible chromatin regions, enabling high-efficiency, high-throughput, and high-resolution inference of regulatory activity.Type: GrantFiled: October 17, 2018Date of Patent: May 21, 2024Assignees: Massachusetts Institute of Technology, Beth Israel Deaconess Medical CenterInventors: Melina Claussnitzer, Liang He, Manolis Kellis, Xinchen Wang
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Patent number: 11987657Abstract: Polymers comprising fluorinated side chains that can be used for water resistance coatings on substrates and are deposited by initiated chemical vapor deposition are generally described.Type: GrantFiled: August 2, 2018Date of Patent: May 21, 2024Assignee: Massachusetts Institute of TechnologyInventors: Kripa K. Varanasi, Karen K. Gleason, Dan Soto, Asli Ugur Katmis
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Patent number: 11986274Abstract: The systems, devices, and methods presented herein use a heart pump to obtain measurements of cardiovascular function. The heart pumps described herein can operate in parallel with and unload the heart. The system can quantify the functioning of the native heart by measuring certain parameters/signals such as pressure or motor current, then calculate and display one or more metrics of cardiovascular function. These metrics, such as left ventricular end diastolic pressure (LVEDP), left ventricular pressure, and contractility, provide valuable information to a user regarding a patient's state of heart function and recovery.Type: GrantFiled: November 3, 2021Date of Patent: May 21, 2024Assignees: ABIOMED, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Elazer Edelman, Brian Chang, Noam Josephy, Sonya Sanat Bhavsar
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Publication number: 20240162105Abstract: A semiconductor device having an electric field management layer. The electric field management layer comprises a material with a relatively high dielectric constant that minimizes the risk of an electric field within the semiconductor device breaking down and damaging the semiconductor device.Type: ApplicationFiled: March 29, 2022Publication date: May 16, 2024Applicant: Massachusetts Institute of TechnologyInventors: Tomas Palacios, Ahmad Zubair, John Niroula
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Publication number: 20240158810Abstract: The disclosure features compositions and methods for ameliorating cognitive impairments associated with neuropsychiatric disorders, particularly those associated with anterodorsal (AD) thalamus hyperexcitability in the brain of a subject. Various embodiments of the disclosure provide for personalized and targeted therapeutic approaches for screening, diagnosing, preventing, and treating cognitive impairments and neuropsychiatric disorders.Type: ApplicationFiled: December 22, 2023Publication date: May 16, 2024Applicants: The Broad Institute, Inc., Massachusetts Institute of TechnologyInventors: Guoping FENG, Dheeraj ROY, Ying ZHANG
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Publication number: 20240156911Abstract: Methods for identifying patients susceptible to treatment with checkpoint inhibitors are provided herein. Also provided are reagents for analyzing T cell responses for understanding resistance to checkpoint inhibitor therapy and understanding therapeutics for overcoming that resistance. Therapeutic strategies, for instance, for treating cancer, are also provided.Type: ApplicationFiled: March 7, 2022Publication date: May 16, 2024Applicant: Massachusetts Institute of TechnologyInventors: Karl Dane Wittrup, J. Christopher Love, Stefani Spranger, Brendan Horton, Duncan Morgan
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Publication number: 20240163981Abstract: A thermal energy storage system includes a firebrick checkerwork and an electrode. The firebrick checkerwork includes one or more conductive firebrick layers, each including a plurality of electrically conductive doped metal oxide firebricks with one or more airflow vents. The electrode includes one or more electrode firebrick layers, each layer including a plurality of electrode firebricks. The firebrick checkerwork is heated due to application of electrical power to the electrode. Air flowing through the firebrick checkerwork may then be heated for use in heat-related applications (e.g., an industrial application, commercial application, residential application, transportation application, etc.) some of which may relate to electricity production or in other applications which may relate to other purposes that require heat that are unrelated to electricity production.Type: ApplicationFiled: December 1, 2023Publication date: May 16, 2024Applicant: Massachusetts Institute of TechnologyInventors: Charles Forsberg, Daniel C. Stack
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Patent number: 11985451Abstract: A method of generating uniform large-scale optical focus arrays (LOT As) with a phase spatial light modulator (SLM) includes identifying and removing undesired phase rotation in the iterative Fourier transform algorithm (IFTA), thereby producing computer-generated holograms of highly uniform LOT As using a reduced number of iterations as compared to a weighted Gerchberg-Saxton algorithm. The method also enables a faster compensation of optical system-induced LOT A intensity inhomogeneity than the conventional IFTA.Type: GrantFiled: February 21, 2020Date of Patent: May 14, 2024Assignees: President and Fellows of Harvard College, Massachusetts Institute of TechnologyInventors: Donggyu Kim, Alexander Keesling Contreras, Ahmed Omran, Harry Jay Levine, Hannes Bernien, Mikhail D. Lukin, Dirk R. Englund
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Patent number: 11981909Abstract: Disclosed are methods and constructs for engineering circular RNA Disclosed is a vector for making circular RNA, said vector comprising the following elements operably connected to each other and arranged in the following sequence: a) a 5? homology arm, b) a 3? group I intron fragment containing a 3? splice site dinucleotide, c) an optional 5? spacer sequence, d) a protein coding or noncoding region, e) an optional 3? spacer sequence, f) a 5? Group I intron fragment containing a 5? splice site dinucleotide, and g) a 3? homology arm. This vector allows production of a circular RNA that is translatable or biologically active inside eukaryotic cells. In one embodiment, the vector can comprise the 5? spacer sequence, but not the 3? spacer sequence. In yet another embodiment, the vector can also comprise the 3? spacer sequence, but not the 5? spacer sequence.Type: GrantFiled: June 5, 2019Date of Patent: May 14, 2024Assignee: Massachusetts Institute of TechnologyInventors: Daniel G. Anderson, Robert Alexander Wesselhoeft, Piotr S. Kowalski
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Publication number: 20240149036Abstract: Described herein is an apparatus, comprising a substrate having a top surface and a bottom surface. In an embodiment, the apparatus comprises one or more piezoelectric transducers having a diameter of about 10 mm and a thickness of about 2 mm, embedded in the substrate. In an embodiment, the apparatus comprises one or more cavitation chambers having a depth of about 1 mm, each of the one or more cavitation chambers disposed between respective ones of the one or more piezoelectric transducers and the top surface of the substrate, wherein the one or more piezoelectric transducers generate vibrations within a frequency range about 20 kHz to about 1 MHz in the cavitation chambers that cause a substance stored in the cavitation chambers to be forcibly moved through the top surface of the substrate.Type: ApplicationFiled: November 2, 2023Publication date: May 9, 2024Applicant: Massachusetts Institute of TechnologyInventors: Canan DAGDEVIREN, Aastha SHAH
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Publication number: 20240153115Abstract: Retrographic sensors described herein may provide smaller sensors capable of high-resolution three-dimensional reconstruction of an object in contact with the sensor. Such sensors may be used by robots for work in narrow environments, fine manipulation tasks, and other applications. To provide a smaller sensor, a reduced number of light sources may be provided in the sensor in some embodiments. For example, three light sources, two light sources, or one light source, may be used in some sensors. When fewer light sources are provided, full color gradient information may not be provided. Instead, the missing gradients in one direction or other information related to a three-dimensional object in contact with the sensor may be determined using gradients in a different direction that were provided by the real data. This may be done using a trained statistical model, such as a neural network, in some embodiments.Type: ApplicationFiled: January 6, 2022Publication date: May 9, 2024Applicant: Massachusetts Institute of TechnologyInventors: Shaoxiong Wang, Branden Romero, Yu She, Edward Adelson
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Publication number: 20240150413Abstract: In aspects, the invention provides novel compositions and methods for dominant inhibition of viral infection.Type: ApplicationFiled: March 11, 2022Publication date: May 9, 2024Applicant: Massachusetts Institute of TechnologyInventors: Alexi G. Choueiri, Yong Qian, Bowen Li, Robert S. Langer, Daniel G. Anderson, Edward S. Boyden
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Publication number: 20240150235Abstract: Reaction schemes involving acids and bases; reactors comprising spatially varying chemical composition gradients (e.g., spatially varying pH gradients), and associated systems and methods, are generally described.Type: ApplicationFiled: December 22, 2023Publication date: May 9, 2024Applicant: Massachusetts Institute of TechnologyInventors: Yet-Ming Chiang, Leah Ellis, Andres Badel
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Publication number: 20240153763Abstract: Systems and methods for growth of silicon carbide over a layer comprising graphene and/or hexagonal boron nitride, and related articles, are generally described. In some embodiments, a SiC film is fabricated over a layer comprising graphene and/or hexagonal boron nitride, which in turn is disposed over a substrate. The layer and/or the substrate may be lattice-matched with the SiC film to reduce defect density in the SiC film. The fabricated SiC film may then be removed from the substrate via, for example, a stressor attached to the SiC film. In certain cases, the layer serves as a reusable platform for growing SiC films and also serves a release layer that allows fast, precise, and repeatable release at the layer surface.Type: ApplicationFiled: October 13, 2023Publication date: May 9, 2024Applicants: Massachusetts Institute of Technology, The Government of the United States of America, as Represented by the Secretary of the Navy, ROHM Co. Ltd.Inventors: Rachael L. Myers-Ward, Jeehwan Kim, Kuan Qiao, Wei Kong, David Kurt Gaskill, Takuji Maekawa, Noriyuki Masago
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Patent number: 11977030Abstract: Disclosed herein are systems and methods of obtaining a derivative Raman spectrum using an excitation or Raman pump beam whose wavelength is modulated in any suitable manner such as, for example, stochastically. Shifting the wavelength of the input excitation by a small amount in approaches like SERDS can isolate the Raman scatter from other spectral artifacts and reduce the false detection rate. For example, an input excitation sequence can be correlated with the response of an individual pixel of a detector. From this, pixels that have captured Raman scattered photons can be separated from pixels capturing non-Raman photons. These techniques can be expanded to other fields and/or types of spectroscopies that utilize a dispersive element detector with time-dependent spectral features.Type: GrantFiled: January 12, 2022Date of Patent: May 7, 2024Assignee: Massachusetts Institute of TechnologyInventors: Michael Zervas, Ian W Hunter