Patents Assigned to MASSACHUSETTS INSTITUTE OF TECHNOLOGIES
  • Optimized fuel management system for direct injection ethanol enhancement of gasoline engines
    Patent number: 10746110
    Abstract: Fuel management system for enhanced operation of a spark ignition gasoline engine. Injectors inject an anti-knock agent such as ethanol directly into a cylinder. It is preferred that the direct injection occur after the inlet valve is closed. It is also preferred that stoichiometric operation with a three way catalyst be used to minimize emissions. In addition, it is also preferred that the anti-knock agents have a heat of vaporization per unit of combustion energy that is at least three times that of gasoline.
    Type: Grant
    Filed: January 18, 2019
    Date of Patent: August 18, 2020
    Assignee: Massachusetts Institute of Technology
    Inventors: Leslie Bromberg, Daniel R. Cohn, John B. Heywood
  • HiC: method of identifying interactions between genomic loci
    Patent number: 10745744
    Abstract: The disclosed Hi-C protocol can identify genomic loci that are spatially co-located in vivo. These spatial co-locations may include, but are not limited to, intrachromosomal interactions and/or interchromosomal interactions. Hi-C techniques may be applied to many different scales of interest. For example, on a large scale, Hi-C techniques can be used to identify long-range interactions between distant genomic loci.
    Type: Grant
    Filed: June 15, 2017
    Date of Patent: August 18, 2020
    Assignees: University of Massachusetts, Massachusetts Institute of Technology, President and Fellows of Harvard College, Whitehead Institute for Biomedical Research
    Inventors: Job Dekker, Erez Lieberman Aiden, Nynke Van Berkum, Andreas Gnirke, Eric Lander, Chad Nusbaum, Louise Williams, Alexandre Melnikov, Georgia Giannoukos
  • Current crowding in three-terminal superconducting devices and related methods
    Patent number: 10749097
    Abstract: An active three-terminal superconducting device having an intersection region at which a hot spot may be controllably formed is described. The intersection region may exhibit current crowding in response to imbalances in current densities applied to channels connected to intersection region. The current crowding may form a hot spot, in which the superconducting device may exhibit a measurable resistance. In some cases, a three-terminal superconducting device may be configured to sense an amount of superconducting current flowing in a channel or loop without having to perturb the superconducting state or amount of current flowing in the channel. A three-terminal superconducting device may be used to read out a number of fluxons stored in a superconducting memory element.
    Type: Grant
    Filed: April 1, 2016
    Date of Patent: August 18, 2020
    Assignee: Massachusetts Institute of Technology
    Inventors: Adam N. McCaughan, Karl K. Berggren, Qingyuan Zhao
  • Determining surface characteristics
    Patent number: 10746867
    Abstract: A method for determining surface characteristics is disclosed. The method may include transmitting a surface penetrating radar (SPR) signal towards a surface from a SPR system. The method may also include receiving a response signal at the SPR system. The response signal may include, at least in part, a reflection of the SPR signal from a surface region associated with the surface. The method may further include measuring at least one of an intensity and a phase of the response signal. The method my additionally include determining, based at least in part on the at least one of the intensity and the phase of the response signal, a surface characteristic of the surface.
    Type: Grant
    Filed: January 29, 2018
    Date of Patent: August 18, 2020
    Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Byron McCall Stanley, Matthew Tyler Cornick
  • Multi-link modular continuum robotic endoscope system
    Patent number: 10743750
    Abstract: Robotic endoscopes have the potential to help endoscopists position tools during procedures, to propel the endoscope to the desired position, to automate functions and to prevent perforations during procedures. Modular architecture for a continuum robotic endoscope with multiple bending segments along the length of the endoscope. Each of the segments is modular, containing a set of actuation motors that drive short cables in the continuum segments.
    Type: Grant
    Filed: April 28, 2015
    Date of Patent: August 18, 2020
    Assignee: Massachusetts Institute of Technology
    Inventors: Ian W. Hunter, Yi Chen, Jiahui Liang
  • Power converter with capacitive energy transfer and fast dynamic response
    Patent number: 10749434
    Abstract: A converter circuit and related technique for providing high power density power conversion includes a reconfigurable switched capacitor transformation stage coupled to a magnetic converter (or regulation) stage. The circuits and techniques achieve high performance over a wide input voltage range or a wide output voltage range. The converter can be used, for example, to power logic devices in portable battery operated devices.
    Type: Grant
    Filed: November 27, 2019
    Date of Patent: August 18, 2020
    Assignee: Massachusetts Institute of Technology
    Inventors: David M. Giuliano, David J. Perreault, Robert C. N. Pilawa-Podgurski
  • Vital signs monitoring via radio reflections
    Patent number: 10746852
    Abstract: A method for monitoring periodic motions of one or more subjects uses signal reflections from the subjects. The method includes emitting a transmitted signal from a transmitting antenna and receiving a received signal at one or more receiving antennas. The received signal includes a combination of a number of reflections of the transmitted signal, at least some of which are associated with the subjects. The received signal, including the reflections, is processed to determine an estimate of a fundamental frequency of the periodic motions.
    Type: Grant
    Filed: April 28, 2015
    Date of Patent: August 18, 2020
    Assignee: Massachusetts Institute of Technology
    Inventors: Fadel Adib, Zachary Edward Kabelac, Dina Katabi
  • Transferring data in a parallel processing environment
    Patent number: 10747712
    Abstract: An integrated circuit includes a plurality of tiles. Each tile includes a processor, a switch including switching circuitry to forward data over data paths from other tiles to the processor and to switches of other tiles, and a switch memory that stores instruction streams that are able to operate independently for respective output ports of the switch.
    Type: Grant
    Filed: June 2, 2014
    Date of Patent: August 18, 2020
    Assignee: Massachusetts Institute of Technology
    Inventor: Anant Agarwal
  • PHOTOVOLTAIC CELL WITH RESPONSIVE SURFACE FILM
    Publication number: 20200259141
    Abstract: A photovoltaic (PV) cell health monitoring apparatus includes a Radio Frequency Identification (RFID) tag mounted to the PV cell and having identifying information of the PV cell, and a sensor in communication with the RFID tag for measuring health information of the PV cell. The RFID tag stores the measured health information together with time and locality information of the PV cell and responds to an interrogation signal by transmitting the stored information together with the identifying information. A dust sensor in the form of a comb-like electrode array measures electrical capacitance as an indication of an amount of dust on an exposed surface of the PV cell. An RFID tag antenna arranged as a meander-line patch antenna covered with polyethylene has a dual function as a temperature sensor.
    Type: Application
    Filed: February 24, 2020
    Publication date: August 13, 2020
    Applicants: KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS, MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Muhammad A. HAWWA, Hussain M. AL-QAHTANI, M. Wasim RAAD, David E. HARDT
  • High-Performance On-Chip Spectrometers and Spectrum Analyzers
    Publication number: 20200256728
    Abstract: We disclose an on-chip photonic spectroscopy system capable of dramatically improving the signal-to-noise ratio (SNR), dynamic range, and reconstruction quality of Fourier transform spectrometers. Secondly, we disclose a system of components that makes up a complete on-chip RF spectrum analyzer with low-cost and high-performance.
    Type: Application
    Filed: December 11, 2019
    Publication date: August 13, 2020
    Applicant: Massachusetts Institute of Technology
    Inventors: Derek Kita, Carlos Andres Rios Ocampo, Juejun Hu
  • CRISPR EFFECTOR SYSTEM BASED DIAGNOSTICS
    Publication number: 20200254443
    Abstract: Provided herein is a lateral flow diagnostic device and methods of using thereof. The device comprises a substrate and a first end, wherein the first end comprises a sample loading portion. The first end may further comprise a first region loaded with a detectable ligand, a CRISPR effector system, a detection construct, a first test band comprising a biotin ligand, and a second test band comprising a capture molecule for the detectable ligand. The detection construct may comprise an RNA oligonucleotide, having a first molecule such as FITC on a first end and a second molecule such as FAM on a second end. Contacting the sample loading portion with a sample causes the sample to flow from the sample loading portion of the substrate towards the first and second capture regions, thereby generating a detectable signal, which may be indicative of a disease state.
    Type: Application
    Filed: October 4, 2018
    Publication date: August 13, 2020
    Applicants: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY, PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Feng Zhang, Jonathan Gootenberg, Omar Abudayyeh
  • Molecular clock
    Patent number: 10739728
    Abstract: A molecular clock which utilizes a rotational spectrum of gaseous molecules in a sub-THz region for clock stabilization is described. The molecular clock has a fast start-up characteristic and is also robust against mechanical vibration or variation of electromagnetic field. Also described is a chip-scale implementation of a molecular clock. In an embodiment, a molecular clock chipset only consumes a DC power of 66 mW. While providing a highly stable, compact and energy efficient time generator of portable devices.
    Type: Grant
    Filed: December 27, 2018
    Date of Patent: August 11, 2020
    Assignee: Massachusetts Institute of Technology
    Inventors: Ruonan Han, Cheng Wang
  • Methods and apparatus for additive manufacturing along user-specified toolpaths
    Patent number: 10737441
    Abstract: One or more input/output devices accept user-inputted path instructions that specify a set of multiple deposition paths for an extruder to travel. An actuator actuates motion of the extruder along a trajectory that includes each of the deposition paths and also includes multiple non-deposition paths. For each deposition path: (a) the user-inputted path instructions specify a thickness of an object; and (b) the extruder extrudes the object in accordance with fabrication instructions computed by a computer based at least in part on the thickness. As the extruder moves over the entire trajectory, the extruder extrudes a set of objects, one object per deposition path. The objects adhere to each other to form an integral 3D structure. In some cases, the objects include functionally graded material.
    Type: Grant
    Filed: March 27, 2019
    Date of Patent: August 11, 2020
    Assignee: Massachusetts Institute of Technology
    Inventors: Jorge Duro Royo, Laia Mogas Soldevila, Neri Oxman
  • Phosphor-loaded waveguide
    Patent number: 10740493
    Abstract: An improved waveguide is disclosed. The waveguide utilizes a luminescent material disposed within or around its perimeter to introduce additional light into the waveguide. For example, the waveguide may include a plurality of planar layers having different refractive indexes. A luminescent material may be disposed along the outer edge of these layers. When light from within the waveguide strikes the luminescent material, it emits light, thereby adding to the light in the waveguide. Not only does the luminescent material introduce more light into the waveguide, it also introduces more light sources, thereby making it more difficult to introduce a probe without blocking at least a portion of the light destined for the image sensor. The luminescent material may be a phosphor.
    Type: Grant
    Filed: February 29, 2016
    Date of Patent: August 11, 2020
    Assignee: Massachusetts Institute of Technology
    Inventors: Michael W. Geis, Joshua Kramer, Karen M.G.V. Gettings, Marc J. Burke, Mankuan M. Vai, Theodore M. Lyszczarz
  • Bi-directional porous media phase change heat exchanger
    Patent number: 10739089
    Abstract: Heat exchange structure. A hydrophilic, thermally conductive porous medium includes nanostructures formed substantially uniformly throughout the porous medium providing a balance of capillary and viscous forces to self-regulate a liquid-vapor contact line. A suitable porous medium is copper. A method for making the structure is also disclosed.
    Type: Grant
    Filed: March 27, 2014
    Date of Patent: August 11, 2020
    Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Ian Salmon McKay, Shankar Narayanan, Evelyn N. Wang
  • Functionalized triptycene polymers and their uses
    Patent number: 10738157
    Abstract: Embodiments described herein relate to compositions including iptycene-based structures. Some embodiments provide compositions including polymers having a backbone comprising an iptycene-based compound. Some embodiments described herein provide compositions having enhanced properties such as enhanced porosity, increased glass transition temperatures, and/or improved solubility as compared to traditional poly(aryl ether)-based compounds or traditional iptycene-based compounds. In some cases, the compositions may include various aryl ether compounds such as an aryl ether ketone incorporated into the polymer backbone. Non-limiting examples of suitable aryl ether compounds include polyaylethersulfones, polyaryletherketones, polyetherimides, and polyphenylene ethers.
    Type: Grant
    Filed: July 20, 2016
    Date of Patent: August 11, 2020
    Assignee: Massachusetts Institute of Technology
    Inventors: Timothy M. Swager, John B. Goods, Chuanhui L. Moh
  • Compositions containing PUFA and/or uridine and methods of use thereof
    Patent number: 10736912
    Abstract: This invention provides methods of enhancing brain development; increasing or enhancing intelligence; increasing or enhancing synthesis and levels of phospholipids, synapses, synaptic proteins, and synaptic membranes by a neural cell or brain cell, comprising contacting a subject or a pregnant or nursing mother thereof with a composition comprising an omega-3 fatty acid, an omega-6 fatty acid, and/or uridine, a metabolic precursor thereof, or a combination thereof.
    Type: Grant
    Filed: October 1, 2018
    Date of Patent: August 11, 2020
    Assignee: Massachusetts Institute of Technology
    Inventors: Richard Wurtman, Ingrid Richardson
  • Vaccine nanotechnology
    Patent number: 10736848
    Abstract: The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides vaccine nanocarriers capable of stimulating an immune response in T cells and/or in B cells, in some embodiments, comprising at least one immunomodulatory agent, and optionally comprising at least one targeting moiety and optionally at least one immunostimulatory agent. The invention provides pharmaceutical compositions comprising inventive vaccine nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive vaccine nanocarriers and pharmaceutical compositions thereof. The invention provides methods of prophylaxis and/or treatment of diseases, disorders, and conditions comprising administering at least one inventive vaccine nanocarrier to a subject in need thereof.
    Type: Grant
    Filed: October 12, 2008
    Date of Patent: August 11, 2020
    Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc., President and Fellows of Harvard College, The Children's Medical Center Corporation
    Inventors: Ulrich H. Von Andrian, Omid C. Farokhzad, Robert S. Langer, Tobias Junt, Elliott Ashley Moseman, Liangfang Zhang, Pamela Basto, Matteo Iannacone, Frank Alexis
  • Brush-poly (glycoamidoamine)-lipids and uses thereof
    Patent number: 10736966
    Abstract: The present disclosure provides brush-poly(glycoamidoamine)-lipids (PGALs) (e.g., polymers of any one of Formulae (I)-(IV)) and methods of preparing the PGALs. A described PGAL may include poly(glycoamidoamine)-derived moieties (e.g., such as which may assist the PGAL and/or a complex of the PGAL and an agent to pass through cell membranes or be taken up by cells. Also provided are compositions including a described PGAL and an agent (e.g., polynucleotide, small molecule, peptide, or protein).
    Type: Grant
    Filed: August 12, 2015
    Date of Patent: August 11, 2020
    Assignee: Massachusetts Institute of Technology
    Inventors: Yizhou Dong, Joseph R. Dorkin, Robert S. Langer, Daniel Griffith Anderson
  • Controllably degradable compositions and methods
    Patent number: 10736914
    Abstract: Methods for treating, adhering, or sealing biological tissue are provided. The methods include combining solutions containing a polymer component and a dendrimer component capable of reacting with each other, and at least one of the components includes a substituent capable of photoreversible dimerization that can be reversibly dimerized. Drug delivery compositions and kits containing these two components also are provided.
    Type: Grant
    Filed: January 29, 2018
    Date of Patent: August 11, 2020
    Assignee: Massachusetts Institute of Technology
    Inventors: Natalie Artzi, Elazer R. Edelman, Regina Kelmansky, Marc Mier Cervantes