Patents Assigned to Massachusetts Institute of Technologoy
  • Polymer-encapsulated reverse micelles
    Patent number: 8193334
    Abstract: A method for encapsulating nucleic acids, particularly siRNAs, shRNAs, microRNAs, gene therapy plasmids, and other oligonucleotides in biodegradable polymers is disclosed, whereby the nucleic acids are formulated into reverse micelles composed of non-toxic and/or naturally-occurring lipids prior to nanoparticle formation by nanoprecipitation. This method can be coupled to other techniques that improve intracellular drug targeting, ultimately enhancing intracellular delivery of the aforementioned nucleic acids.
    Type: Grant
    Filed: October 5, 2009
    Date of Patent: June 5, 2012
    Assignees: The Brigham and Women's Hospital, Massachusetts Institute of Technologoy
    Inventors: Aleksandar F. Radovic-Moreno, Liangfang Zhang, Robert S. Langer, Omid C. Farokhzad