Patents Assigned to Massachusetts Institute of Technology
  • Publication number: 20230187617
    Abstract: A cathode particle has a core and an outer layer. The core includes a lithium (Li) transition metal (M) oxide. The outer layer is disposed conformally around and substantially encloses the core. The core facilitates oxygen anion redox activity and M cation redox activity. The outer layer substantially prevents oxygen anion redox and oxygen loss in the outer layer. The outer layer of the cathode particle may have a first crystal structure. The outer layer's first crystal structure may be at least one of a layered crystal structure or a spinel crystal structure. The core of the cathode particle may have a second crystal structure that is a layered crystal structure. The core may have a single-crystalline structure. The outer layer may be LiMn0.75Ni0.25O2 or LiMn0.5Ni0.5O4.
    Type: Application
    Filed: April 13, 2021
    Publication date: June 15, 2023
    Applicant: Massachusetts Institute of Technology
    Inventors: Ju LI, Zhi Zhu, Yimeng Huang
  • Publication number: 20230183677
    Abstract: Disclosed herein are biosensors that are hyperspectral reporters. The biosensors are useful for detecting information about the environment and environmental conditions in a number of fields including agriculture. Also provided are methods of making and using the biosensors.
    Type: Application
    Filed: October 7, 2022
    Publication date: June 15, 2023
    Applicant: Massachusetts Institute of Technology
    Inventors: Christopher A. Voigt, Yonatan Chemla, Itai Levin
  • Publication number: 20230183104
    Abstract: An asymmetric system containing a first conductive polymer modified with a redox active moiety and a second conductive polymer modified with a surfactant is used for the separation of organic compounds from aqueous solutions. The asymmetric system has complementary hydrophobicity tunability in response to electrochemical modulations. For example, both materials are hydrophobic in their respective neutral states, therefore exhibiting affinity toward organic compounds. Application of a mild potential drives the desorption of the organic compounds and regeneration of the materials. The asymmetric system can be used in a cyclic fashion, through repeated electrical discharge or shorting of the two electrodes to program the capture of organics from a feed solution, and application of a potential to stimulate the release of the adsorbed organics.
    Type: Application
    Filed: December 21, 2022
    Publication date: June 15, 2023
    Applicant: Massachusetts Institute of Technology
    Inventors: Trevor Alan Hatton, Xianwen Mao, Yinying Ren
  • Publication number: 20230183915
    Abstract: Devices and methods related to drying absorbent articles with water reactive materials are generally described.
    Type: Application
    Filed: May 28, 2021
    Publication date: June 15, 2023
    Applicants: Massachusetts Institute of Technology, United States Marine Corps
    Inventors: Erik Limpaecher, Jacob Clayton, Douglas Baker, William Hornsby
  • Publication number: 20230181463
    Abstract: The present disclosure provides oleogel and oleopaste compositions, as well as methods, kits, preparations, and methods of using the same. The oleogels and oleopastes presented herein include compositions comprising azithromycin, albendazole, lumefantrine, praziquantel, moxifloxacin, and ivermectin.
    Type: Application
    Filed: May 14, 2021
    Publication date: June 15, 2023
    Applicants: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.
    Inventors: Robert S. Langer, Carlo Giovanni Traverso, Ameya R. Kirtane, Aniket Wahane, Christina Karavasili
  • Publication number: 20230183860
    Abstract: A flow through valve can satisfy the manufacturing constraints encountered when handling materials at high temperatures and low pressures, for example during semiconductor thin-film manufacturing using techniques such as vapor transport deposition.
    Type: Application
    Filed: December 12, 2022
    Publication date: June 15, 2023
    Applicant: Massachusetts Institute of Technology
    Inventors: Vladimir BULOVIC, Ella WASSWEILER, Anurag PANDA
  • Publication number: 20230183168
    Abstract: Provided herein are compounds, such as compounds of Formula (I), and pharmaceutically acceptable salts, hydrates, solvates, polymorphs, co-crystals, tautomers, stereoisomers, and isotopically labeled derivatives thereof, and compositions, methods, uses, and kits thereof. The compounds provided herein are lipids useful for delivery of polynucleotides, such as mRNA, for the treatment and/or prevention of various diseases and conditions (e.g., genetic disease, proliferative disease, hematological disease, neurological disease, liver disease, spleen disease, lung disease, painful condition, psychiatric disorder, musculoskeletal disease, a metabolic disorder, inflammatory disease, or autoimmune disease).
    Type: Application
    Filed: December 13, 2022
    Publication date: June 15, 2023
    Applicant: Massachusetts Institute of Technology
    Inventors: Daniel Griffith Anderson, Luke Hyunsik Rhym, Allen Jiang, Jacob Witten, Idris Raji
  • Publication number: 20230184684
    Abstract: The present invention relates to the use of a Raman spectral signature of nitrate, as a biomarker for an early, real-time diagnosis of nitrogen status in growing plants in a non-invasive or non-destructive way in order to detect nitrogen deficiency before the onset of any visible symptoms. The early, real-time diagnosis of nitrogen deficiency in plants makes it possible to correct nitrogen deficiency for the avoidance of negative effects on the yield and biomass of growing plants or leafy vegetables.
    Type: Application
    Filed: May 20, 2021
    Publication date: June 15, 2023
    Applicants: TEMASEK LIFE SCIENCES LABORATORY LIMITED, MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Bong Soo PARK, Rajeev J. RAM, Chung Hao HUANG, Gajendra Pratap SINGH, Nam-Hai CHUA
  • Patent number: 11676389
    Abstract: Described herein are systems and methods for locating an object detected in a video. The system detects a bounding box at least partially around an object in a first frame at a first time in the video and a second frame in the video corresponding to a second time. The system determines whether there is no motion within the bounding box of the second frame. The system compares edge information, or color information, or intensity information associated with one or more pixels in the first frame, to edge information, or color information, or intensity information associated with one or more pixels within the bounding box. The system generates a score based on the comparison. The system further determines based on the score if the object is present in the second frame. The system also determines an estimated timeframe window of a first appearance of the object.
    Type: Grant
    Filed: May 20, 2020
    Date of Patent: June 13, 2023
    Assignee: Massachusetts Institute of Technology
    Inventors: Marianne A. DeAngelus, Jason R. Thornton, Ronald Duarte, Aaron Z. Yahr, Christine M. Russ, Zach Elko
  • Patent number: 11677078
    Abstract: The present disclosure relates to electrodes comprising a polymer film and a substrate, wherein the polymer film has a thickness of about 5 nm to about 600 nm. The present disclosure also relates to electrochemical cells and batteries comprising the electrodes disclosed herein. The present disclosure also relates to methods of making the electrodes disclosed herein.
    Type: Grant
    Filed: July 8, 2021
    Date of Patent: June 13, 2023
    Assignee: Massachusetts Institute of Technology
    Inventors: Karen K. Gleason, Fikile Brushett, Charles Wan, Antoni Forner-Cuenca, Meysam Heydari Gharahcheshmeh, Yasser Ashraf Gandomi
  • Patent number: 11673865
    Abstract: Provided herein are dibenzocyclooctyne compounds useful as reagents in 1,3-dipolar cycloaddition reactions, and methods for their preparation.
    Type: Grant
    Filed: April 29, 2022
    Date of Patent: June 13, 2023
    Assignee: Massachusetts Institute of Technology
    Inventors: Ronald T. Raines, Brian Gold, Jesus M. Dones, Nile S. Abularrage, Brian James Graham
  • Patent number: 11672864
    Abstract: Self-assembled gel compositions including a gelator, e.g., an enzyme-cleavable gelator, e.g., having a molecular weight of 2500 or less, are described. The self-assembled gel compositions can encapsulate one or more agents. Methods of making the self-assembled gel compositions, and methods of drug delivery using the self-assembled gel compositions are also described.
    Type: Grant
    Filed: June 8, 2020
    Date of Patent: June 13, 2023
    Assignees: The Brigham And Women's Hospital, Inc., Massachusetts Institute Of Technology
    Inventors: Jeffrey M. Karp, Praveen Kumar Vemula, Nathaniel R. Campbell, Abdullah M. Syed, Sufeng Zhang, Omid C. Farokhzad, Robert S. Langer
  • Patent number: 11674205
    Abstract: Provided in one embodiment is a method, comprising: sintering a plurality of nanocrystalline particulates to form a nanocrystalline alloy, wherein at least some of the nanocrystalline particulates may include a non-equilibrium phase comprising a first metal material and a second metal material, and the first metal material may be soluble in the second metal material. The sintered nanocrystalline alloy may comprise a bulk nanocrystalline alloy.
    Type: Grant
    Filed: August 12, 2019
    Date of Patent: June 13, 2023
    Assignee: Massachusetts Institute of Technology
    Inventors: Christopher A. Schuh, Mansoo Park
  • Patent number: 11672507
    Abstract: Systems and methods for ultrasound shear wave elastography (SWE) are described. According to examples, an ultrasound SWE system includes an ultrasound probe (120), an actuation assembly (130) coupled to the probe and configured to apply an external force against a subject for generating a shear wave within a target region, a controller (140) coupled to the actuation assembly to control the actuation assembly to apply the force responsive to a trigger signal, and ultrasound scanner (110) configured to generate the trigger signal, and further configured to generate an elastography image based at least in part on echo signals received from the target region.
    Type: Grant
    Filed: March 30, 2018
    Date of Patent: June 13, 2023
    Assignees: KONINKLIJKE PHILIPS N.V., MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Man Nguyen, Hua Xie, Sheng-Wen Huang, Brian Anthony, Heng Yang
  • Patent number: 11678112
    Abstract: An ultra-wide bandwidth acoustic transducer may include multiple layers, including an inner piezoelectric layer, a polymer coupling layer and an outer piezoelectric layer. The polymer layer may be located between, and may be bonded to, the inner and outer piezoelectric layers. The transducer may have multiple eigenfrequencies of vibration. These eigenfrequencies may include primary resonant frequencies of the inner and outer piezoelectric layers respectively and may also include resonant frequencies that arise due to coupling between the layers. An acoustic backscatter system may employ such a transducer in backscatter nodes as well as in a transmitter. The multiple eigenfrequencies may enable the system to perform spread-spectrum communication at a high throughput. These multiple eigenfrequencies may also enable each backscatter node to shift frequency of an uplink signal, which in turn may enable the system to mitigate self-interference and to decode concurrent signals from multiple backscatter nodes.
    Type: Grant
    Filed: April 11, 2021
    Date of Patent: June 13, 2023
    Assignee: Massachusetts Institute of Technology
    Inventors: Reza Ghaffarivardavagh, Sayed Saad Afzal, Osvy Rodriguez, Fadel Adib
  • Patent number: 11672888
    Abstract: Methods for generating porous scaffolds may include tuning a porogen/crystallite's particle size to a desired range and mixing the crystallite particles with a polymer solution. The mixture is then cast to form films. The films are rolled and consolidated around another inner material to create a preform, which is then thermally drawn. The inner material and the porogen can be selectively removed to obtain porous constructs/fibers. The structures can be fuse-printed to produce complex tissue scaffolds with dimensions up to several centimeters and beyond.
    Type: Grant
    Filed: November 26, 2019
    Date of Patent: June 13, 2023
    Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.
    Inventors: Polina Olegovna Anikeeva, Dena Shahriari, Yoel Fink, Zi Jie Gabriel Loke, Ian James Tafel
  • Patent number: 11672436
    Abstract: Heart rates and beat lengths of a subject can be extracted from videos of the subject by measuring subtle head motion caused by the Newtonian reaction to the influx of blood at each beat. Embodiments track features on the video images of the subject's head and perform principal component analysis (PCA) to decompose the feature location-time series into a set of component motions. The method or system then selects a component that best corresponds to heartbeats based on its temporal frequency spectrum. Finally, the motion projected to this component is analyzed and peaks of the location-time series are identified, which correspond to heartbeats. Pulse rate measurements or heart rate measurements of the subject are output.
    Type: Grant
    Filed: March 19, 2020
    Date of Patent: June 13, 2023
    Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Guha Balakrishnan, John V. Guttag, Frederic Durand
  • Patent number: 11672869
    Abstract: The present invention relates to compositions and methods associated with antibody-bacterial effector translocase protein conjugates. Some aspects of the present invention relate to preventing or treating diseases using the antibody-protective antigen conjugates. Further aspects of the present invention relate to methods of chemically conjugating and synthesizing the antibody-bacterial effector translocase protein conjugates.
    Type: Grant
    Filed: August 23, 2019
    Date of Patent: June 13, 2023
    Assignee: Massachusetts Institute of Technology
    Inventors: Zeyu Lu, Bradley L. Pentelute
  • Publication number: 20230173295
    Abstract: A method of treating cognitive impairment associated with chemotherapy treatment in a subject in need thereof includes on-invasively delivering a combined stimulus to the subject to invoke gamma entrainment in a brain of the subject. The combined stimulus includes an auditory stimulus having a frequency of from about 20 Hz to about 60 Hz, and a visual stimulus having a frequency of from about 20 Hz to about 60 Hz.
    Type: Application
    Filed: April 23, 2021
    Publication date: June 8, 2023
    Applicant: Massachusetts Institute of Technology
    Inventors: Thomas Aquinas Kim, Li-Huei Tsai
  • Publication number: 20230174396
    Abstract: Disclosed herein are methods of using reactor outputs to purify materials. For example, methods of using acid and/or base produced in a reactor to purify materials (e.g., limestone, dolomite, waste streams, and/or ash) are described herein. Related systems are also described.
    Type: Application
    Filed: April 29, 2021
    Publication date: June 8, 2023
    Applicant: Massachusetts Institute of Technology
    Inventors: Yet-Ming Chiang, Leah Ellis