Abstract: Methods of manufacturing tissue interfacing components, such as solid needles comprising one or more therapeutic agents, are disclosed. In some embodiments, a method for manufacturing a tissue interfacing component comprises compressing a granular therapeutic agent within a mold cavity of a mold to form a solid tissue interfacing component. The mold cavity may define an elongated shape extending along a longitudinal axis from an opening of the mold cavity to a distal end of the mold cavity, and the granular therapeutic agent may be compressed by moving a mold punch along the longitudinal axis towards the distal end. After compressing the granular therapeutic agent to form the solid tissue interfacing component, the tissue interfacing component may be removed from the mold and subsequently inserted into tissue to deliver the therapeutic agent to a subject.

Abstract: A transformer system is provided that includes four magnetically coupled coils having fixed spacing geometry. The four magnetically coupled coils include a drive coil that produces magnetic fields and a load coil. All coils are coupled in the transformer system, but the first resonant coil is highly coupled with the drive coil so that the resonant coil can receive energy from the drive coil and the second resonant coil is highly coupled to the load coil so that the load coil can extract energy efficiently from the second resonant coil.

Abstract: Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject).

Abstract: Radioactive nuclides (radionuclides) are separate from an aqueous radioactive liquid by feeding the liquid into a chamber between a porous anode and a porous cathode of a shock electrodialysis device. Meanwhile, an anolyte is fed through the porous anode, and a catholyte is fed through the porous cathode. A voltage is applied to the porous anode and to the porous cathode to create a voltage differential across the chamber. The liquid is passed through the chamber, and cations are selectively driven from the liquid into the cathode by the voltage differential. The voltage differential creates a desalination shock that produces an ion-enriched zone on one side of the desalination shock and a deionized zone on an opposite side. A brine including the radioactive cations is extracted from the ion-enriched zone through a brine outlet, and fresh water is extracted from the deionized zone through a fresh-water outlet.

Abstract: A method is directed to continuously, non-invasively, and directly measuring blood pressure, and includes providing a calibrated measurement device having a blood-flow control balloon and a sensor array. The method further includes placing the sensor array in a non-invasive manner over the surface of a patch of skin connected to an artery by adjoining soft tissues and inflating the blood-flow control balloon with a controlled amount of pressure. In response to the inflating of the blood-flow control balloon, changes in the artery geometry and forces are detected, via the sensor array, during a heartbeat cycle. The changes correspond to spatio-temporal signals from the artery or in the adjoining soft tissues. The spatio-temporal signals are measured and processed, via a controller, to determine blood-pressure parameters.

Abstract: A photonic parallel network can be used to sample combinatorially hard distributions of Ising problems. The photonic parallel network, also called a photonic processor, finds the ground state of a general Ising problem and can probe critical behaviors of universality classes and their critical exponents. In addition to the attractive features of photonic networks—passivity, parallelization, high-speed and low-power—the photonic processor exploits dynamic noise that occurs during the detection process to find ground states more efficiently.

Abstract: The present invention generally relates to a modular microjet cooler. The modular microjet cooler may be attached to a packaged heat generating device that is mounted on a printed circuit board. The modular microjet cooler has an inlet allowing supply fluid to be directed through microjet nozzles toward an impingement surface on the packaged device. The modular microjet cooler also has one or more outlets that allow exhaust fluid to be removed. The modular microjet cooler is attached to the device after it has been packaged. Further, the modular microjet cooler may be attached to the packaged device either before or after it is mounted to the printed circuit board.

Abstract: An anti-icing coating can include an amphiphilic copolymer on a surface of an article.

Abstract: An equivalent time network analyzer and method estimates a device-under-test's frequency response by acquiring its time domain response through equivalent time over-sampling. The analyzer has a timing system producing two time bases differing in period by less than one part per million, resulting in a linearly varying phase difference. A high frequency stimulus generator, synchronized to the first time basis, creates a periodic waveform that contains energy at harmonics of the first time basis. An output capture cell that captures the response of the device-under-test includes a high bandwidth input comparator, a memory element clocked to the second time basis, and a low bandwidth feedback filter that provides a low frequency analog estimate of the time domain response of the device-under-test as feedback to the input comparator and as output from the capture cell. The analyzer may also include input capture cells, multiple stimulus generators, and/or multiple output capture cells.

Abstract: Wireless resonant inductive power receivers for achieving detuning for a resonant wireless power transfer system including cooperative power sharing is described. Cooperative power sharing allows for detuning one or more wireless received coupled to a wireless charger to alter the power received at each wireless receiver.

Abstract: The performance of an electro-optic modulator depends in part on the capacitance, the inductance, the electric field distribution, and the signal insertion loss of a microwave transmission line that modulates the refractive index of a waveguide via the electro-optic effect. Conventional electro-optic modulators are typically unable to improve one of these properties without negatively affecting other properties, resulting in lower performance. These shortcomings may be overcome, in part, by the inclusion of capacitive structures to decouple these properties. The capacitive structure may include a fang and/or a hook to tune the capacitance and the electric field distribution without appreciably changing the inductance or the signal insertion losses.

Abstract: A sample may be illuminated in such a way that light passes through the sample, reflects from a set of reflectors, passes through the sample again and travels to a light sensor. The reflectors may be staggered in depth beneath the sample, each reflector being at a different depth. Light reflecting from each reflector, respectively, may arrive at the light sensor during a different time interval than that in which light reflecting from other reflectors arrives—or may have a different phase than that of light reflecting from the other reflectors. The light sensor may separately measure light reflecting from each reflector, respectively. The reflectors may be extremely small, and the separate reflections from the different reflectors may be combined in a super-resolved image. The super-resolved image may have a spatial resolution that is better than that indicated by the diffraction limit.

Abstract: Disclosed are reactive miniproteins, and peptides comprising them. The miniproteins and peptides are amino acid sequences not found in nature that are able to undergo SNAr chemistry and other nucleophilic based reactions. Also disclosed are conjugates comprising at least one of the reactive miniproteins or peptides, and methods of forming these conjugates.

Abstract: Disclosed are methods for fabricating supercapacitors (SCs) via vapor printing, specifically oxidative chemical vapor deposition (oCVD). Also disclosed are methods of using the supercapacitors, in particular for energy storage devices and photovoltaics.

Abstract: An apparatus and a method for sheathing a medical device, tool, instrument or probe (generally, probe) is provided. Among other aspects, a probe support jig capable of supporting the probe is provided, which includes a mechanical coupling for accepting a sheath on a sheath shell. In use, the sheath shell is coupled at one end thereof to the support jig and the probe is fed into the sheath, which is coupled to the sheath shell at another end thereof.

Abstract: An approach to localizing a mobile device takes advantage of the device reporting the order of its neighboring base stations (BSs) according to the received power of the pilot signals. Based on the received BS order, the agent is located within the intersection of corresponding higher-order Voronoi cells. Assuming that the BSs are deployed according to a Poisson point process (PPP) and that signals are subject to log-normal shadowing, the tradeoff between the ALR and the localization error probability can be characterized. It is shown that increasing the number of reported BSs generally reduces the ALR and improves the localization accuracy at the expense of increasing the localization error.

Abstract: Systems and methods relating to tactile dexterity and control are disclosed. In one embodiment, a method of manipulating an object based on tactile sensing includes sensing an object by receiving signals from a tactile sensor of an end effector of a robotic system in contact with the object, controlling a contact state by operating the end effector to enforce a desired contact condition between the end effector and the object, estimating a pose of the object based on the received signals, and planning at least one trajectory of the object based on the estimated pose of the object and a desired pose of the object.

Abstract: Provided herein are methods and systems for detecting a target nucleic acid sequence. The method comprises contacting an oligonucleotide comprising the target nucleic acid sequence with a transposon complex; inserting one or more T7 RNA promoters into the oligonucleotide using the transposase; and (c) amplifying the target nucleic acid sequence. The transposon complex may comprise a transposase and a transposon sequence comprising one or more T7 RNA promoters. The target nucleic sequence may be amplified by generating RNA oligonucleotides comprising the target nucleic acid sequence via transcription from the inserted one or more T7 RNA promoters. The amplified target nucleic acid may be detected using a CRISPR Cas13-based detection system.

Abstract: A high voltage logic circuit for high voltage system application comprises a first device layer formed from a first semiconductor material and comprises a low voltage logic circuit; and a second device layer formed from a second different semiconductor material and comprising one or more components of an additional circuit for generating a high voltage logic output from a low voltage logic input from the low voltage logic circuit; wherein the first and second device layers are integrally formed.

Abstract: Systems and methods for measuring the properties (e.g., mechanical properties) of particles such as biological entities, in a fluidic channel(s) are generally provided. In some embodiments, the systems and methods comprise measuring an acoustic scattering of single particles. For example, a single particle (e.g., a biological entity) may be flowed in a suspended fluidic channel (e.g., a suspended microfluidic channel) and the fluidic channel is oscillated at or near a (mechanical) resonant frequency (e.g., at a second or higher bending mode) of the suspended fluidic channel. In some cases, an acoustic scattering signal (e.g., the change in resonant frequency of the fluidic channel as the particle flows along a longitudinal axis of the channel) may correspond to a property (e.g., a mechanical property, a cross-linking density, a transport rate of small molecules into/out of the particle) of the particle.