Patents Assigned to Massachusetts Institute Technology
  • Patent number: 10492691
    Abstract: Automated tissue stiffness measurement devices and methods can identify cancerous lesions with high sensitivity and specificity. Systems and methods are presented to measure tissue stiffness using applied force, illumination and imaging techniques. The systems and methods can use structured illumination to characterize a tissue surface.
    Type: Grant
    Filed: August 31, 2016
    Date of Patent: December 3, 2019
    Assignee: Massachusetts Institute of Technology
    Inventor: Tyler D. Wortman
  • Patent number: 10498160
    Abstract: Described is a receiver for improving end-to-end efficiency in a device-to-device wireless charging system using resonant energy transfer through an inductive link. The receiver includes an efficiency controller which dynamically tracks a maximum efficiency point and controls an impedance between an inductive coupling of the receiver and a receiver rectifier circuit such that an impedance seen by the inductive coupling is an impedance which maximizes (or nearly maximizes) efficiency of the inductively coupled wireless power transfer operation.
    Type: Grant
    Filed: July 29, 2016
    Date of Patent: December 3, 2019
    Assignee: Massachusetts Institute of Technology
    Inventors: Nachiket V. Desai, Anantha P. Chandrakasan
  • Patent number: 10493441
    Abstract: Compositions and methods for selective olefin (e.g., ethylene) oligomerization comprising metal organic frameworks (MOFs) are generally provided In some embodiments, a MOF comprises a plurality of metal ions, each coordinated with at least one ligand comprising at least two unsaturated N-heterocyclic aromatic groups arranged about an organic core.
    Type: Grant
    Filed: September 14, 2016
    Date of Patent: December 3, 2019
    Assignee: Massachusetts Institute of Technology
    Inventors: Mircea Dinca, Eric D. Metzger, Carl K. Brozek
  • Publication number: 20190359347
    Abstract: System for reducing likelihood of an aircraft-induced lightning strike on an aircraft. The system includes a plurality of electric field sensors distributed on surfaces of the aircraft to monitor continuously the electrical environment to which the aircraft is subjected. A plurality of ion emission sources are distributed on selected aircraft surfaces, the ion emission sources adapted to emit either positive or negative ions. A computer runs an algorithm to control net charge level of the aircraft by commanding the emission of positive or negative ions from selected surfaces to retard inception of corresponding leader discharges.
    Type: Application
    Filed: August 1, 2019
    Publication date: November 28, 2019
    Applicant: Massachusetts Institute of Technology
    Inventors: MANUEL MARTINEZ-SANCHEZ, Carmen Guerra-Garcia, Ngoc Nguyen, Jaime Peraire, Theodore Mouratidis
  • Patent number: 10487354
    Abstract: The present invention relates to methods of quantifying nucleic acids involving (a) contacting a sample to be tested with whole-genome amplification (WGA) reaction components and a dye molecule to form a reaction sample, wherein the dye molecule detects the nucleic acid; (b) partitioning the reaction sample wherein each partitioned reaction sample corresponds to a single reaction; (c) allowing the reaction to occur in the partitioned reaction sample and (d) determining the number of partitioned reaction samples having the dye molecule, wherein the dye molecule indicates the presence of the nucleic acid; thereby quantifying the nucleic acid in the sample to be tested.
    Type: Grant
    Filed: September 11, 2015
    Date of Patent: November 26, 2019
    Assignees: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Paul Blainey, Liyi Xu
  • Patent number: 10488079
    Abstract: Reflectors for solar concentration and methods for formation thereof. A reflective assembly (1340) may include a plurality of elongate panels (370) forming a continuous trough (1330), and a frame (1230) configured to support the panels, with the frame with attached panels defining a parabolic contour on the top side of the trough.
    Type: Grant
    Filed: May 13, 2015
    Date of Patent: November 26, 2019
    Assignee: Massachusetts Institute of Technology
    Inventors: Alexander H. Slocum, Ronald B. Campbell, Jr.
  • Patent number: 10485928
    Abstract: The present invention relate to a method and corresponding apparatus for just in time mixing of a solid or powdered formulation and its subsequent delivery to a biological body. In some embodiments, a powdered formulation is maintained in a first chamber of a plurality of chambers. A plurality of electromagnetic actuators are in communication with the plurality of chambers. The actuators, when activated, generate a pressure within at least the first chamber. The pressure results in mixing of the powdered formulation and a diluent in time for delivering into the biological body.
    Type: Grant
    Filed: October 10, 2017
    Date of Patent: November 26, 2019
    Assignee: Massachusetts Institute of Technology
    Inventors: Ian W. Hunter, Andrew J. Taberner, N. Catherine Hogan
  • Patent number: 10491048
    Abstract: A method includes determining, by a base station including a number of transmitting coils, a first number of mutual magnetic parameters, each mutual magnetic parameter being associated with one of the transmitting coils and a receiving coil of at least one receiving coil associated with at least one electronic device remotely located from and to be remotely charged by the base station, determining a plurality of control signals based on the first number of mutual magnetic parameters, each control signal being associated with a corresponding one of the transmitting coils, providing each control signal to a driving circuit coupled to the control signal's corresponding transmitting coil, and using each control signal to cause the driving circuit coupled to the control signal's corresponding transmitting coil to cause a current with a magnitude and phase determined from the control signal to flow in the corresponding transmitting coil.
    Type: Grant
    Filed: October 11, 2017
    Date of Patent: November 26, 2019
    Assignee: Massachusetts Institute of Technology
    Inventors: Jouya Jadidian, Dina Katabi
  • Patent number: 10485861
    Abstract: Provided herein are new compositions including an inactivated pathogen and one or more adjuvant-loaded polymeric nanoparticles, wherein the adjuvant-loaded nanoparticles are bound to the inactivated pathogen. These compositions are useful for preventing and/or treating diseases caused by the specific pathogens, especially when administered to a subject's mucosal membranes.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: November 26, 2019
    Assignees: President and Fellows of Harvard College, Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.
    Inventors: Georg Stary, Aleksandar Filip Radovic-Moreno, Pamela A. Basto, Michael N. Starnbach, Robert S. Langer, Omid C. Farokhzad, Ulrich Von Andrian
  • Patent number: 10485681
    Abstract: An exoskeleton worn by a human user consists of a rigid pelvic harness, worn about the waist of the user, and exoskeleton leg structures, each of which extends downwardly alongside one of the human user's legs. The leg structures include hip, knee, and ankle joints connected by adjustable length thigh and shin members. The hip joint that attaches the thigh structure to the pelvic harness includes a passive spring or an active actuator to assist in lifting the exoskeleton and the human user with respect to the ground surface upon which the user is walking and to propel the exoskeleton and human user forward. A controllable damper operatively arrests the movement of the knee joint at controllable times during the walking cycle and a spring located at the ankle and foot member stores and releases energy during walking.
    Type: Grant
    Filed: August 19, 2010
    Date of Patent: November 26, 2019
    Assignee: Massachusetts Institute of Technology
    Inventors: Hugh M. Herr, Conor Walsh, Daniel Joseph Paluska, Andrew Valiente, Kenneth Pasch, William Grand
  • Patent number: 10491309
    Abstract: A multi-rate, burst-mode, photon-counting receiver can communicate at data rates up to 10.416 Mb/s over a 30-foot water channel. With added attenuation, the maximum link loss is 97.1 dB at ?=517 nm. In clear ocean water, this equates to link distances up to 148 meters. For ?=470 nm, the achievable link distance in clear ocean water is 450 meters. The receiver incorporates soft-decision forward error correction (FEC) that supports multiple code rates to achieve error-free performance. A burst-mode receiver architecture provides robust performance with respect to unpredictable channel obstructions. The receiver can detect the data rate on-the-fly and adapts to changing levels of signal and background light. The receiver updates its phase alignment and channel estimates every frame, allowing for rapid changes in water quality as well as motion between transmitter and receiver.
    Type: Grant
    Filed: February 3, 2017
    Date of Patent: November 26, 2019
    Assignee: Massachusetts Institute of Technology
    Inventors: Hemonth Rao, Andrew Fletcher, Scott Hamilton, Nicholas Hardy, Marvin Scheinbart
  • Patent number: 10491839
    Abstract: In time-delay-and-integrate (TDI) imaging, a charge-couple device (CCD) integrates and transfers charge across its columns. Unfortunately, the limited well depth of the CCD limits the dynamic range of the resulting image. Fortunately, TDI imaging can be implemented with a digital focal plane array (DFPA) that includes a detector, analog-to-digital converter (ADC), and counter in each pixel and transfer circuitry connected adjacent pixels. During each integration period in the TDI scan, each detector in the DFPA generates a photocurrent that the corresponding ADC turns into digital pulses, which the corresponding counter counts. Between integration periods, the DFPA transfers the counts from one column to the next, just like in a TDI CCD. The DFPA also non-destructively transfers some or all of the counts to a separate memory. A processor uses these counts to estimate photon flux and correct any rollovers caused by “saturation” of the counters.
    Type: Grant
    Filed: October 18, 2018
    Date of Patent: November 26, 2019
    Assignee: Massachusetts Institute of Technology
    Inventors: Curtis B. Colonero, Michael W. Kelly, Megan H. Blackwell, Lauren L. White
  • Publication number: 20190352347
    Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels.
    Type: Application
    Filed: August 2, 2019
    Publication date: November 21, 2019
    Applicants: Massachusetts Institute of Technology, The Governors of the University of Alberta
    Inventors: Nathan KLAPOETKE, Brian Yichiun CHOW, Edward BOYDEN, Gane KA-Shu WONG, Yongku Peter CHO
  • Publication number: 20190352652
    Abstract: The present invention generally relates to plants comprising a CRISPR system or parts of a CRISPR system, compositions, containers, polynucleotide, vectors, delivery systems, parts of plants, methods for production, CRISPR systems, and components thereof. Further aspects of the invention include a method for identifying a CRISPR system which is functional in a plant cell and a method for improving a CRISPR system in a plant.
    Type: Application
    Filed: December 8, 2017
    Publication date: November 21, 2019
    Applicants: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY, REGENTS OF THE UNIVERSITY OF MINNESOTA, PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Omar ABUDAYYEH, Joseph John BELANTO, Jonathan GOOTENBERG, Colby Garret STARKER, Daniel Francis VOYTAS, Feng ZHANG
  • Publication number: 20190355543
    Abstract: An ionic liquid ion source can include a microfabricated body including a base and a tip. The body can be formed of a porous material compatible with at least one of an ionic liquid or room-temperature molten salt. The body can have a pore size gradient that decreases from the base of the body to the tip of the body, such that the at least one of an ionic liquid or room-temperature molten salt is capable of being transported through capillarity from the base to the tip.
    Type: Application
    Filed: July 15, 2019
    Publication date: November 21, 2019
    Applicant: Massachusetts Institute of Technology
    Inventors: Paulo C. Lozano, Steven Mark Arestie
  • Publication number: 20190352243
    Abstract: Compositions and methods of use related to metal organic frameworks (MOFs) and/or nanoparticles are generally described. In some embodiments, methods and compositions for the catalytic upgrading of alcohols using MOFs and/or nanoparticles associated with MOFs are generally described. In some embodiments, a catalytic MOF composition is provided, wherein the MOF composition comprises a MOF compound and a plurality of metal catalytic compounds. In some embodiments, an alcohol may be exposed to the MOF composition and/or a plurality of nanoparticles associated with the MOF composition such that the alcohol is converted to a higher order alcohol. Advantageously, in some embodiments, the alcohol conversion occurs at a relatively high turnover frequency and/or with a relatively high selectivity as compared to traditional methods for converting alcohols.
    Type: Application
    Filed: March 21, 2019
    Publication date: November 21, 2019
    Applicant: Massachusetts Institute of Technology
    Inventors: Mircea Dinca, Constanze Nicole Neumann
  • Patent number: 10480009
    Abstract: Provided herein are recombinase-based frameworks for building state machines in vitro and in vivo by using chemically controlled DNA excision and inversion operations to encode state in DNA sequence.
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: November 19, 2019
    Assignee: Massachusetts Institute of Technology
    Inventors: Timothy Kuan-Ta Lu, Nathaniel B. Roquet
  • Patent number: 10478802
    Abstract: Titania-based porous nanoparticle coatings are mechanically robust, with low haze, which exhibit short time scales for decomposition of fingerprint oils under ultraviolet light. The mechanism by which a typical dactylogram is consumed combines wicking of the sebum into the nanoporous titania structure followed by photocatalytic degradation. These TiO2 nanostructured surfaces are also anti-fogging, anti-bacterial, and compatible with flexible glass substrates and remain photocatalytically active in natural sunlight.
    Type: Grant
    Filed: May 9, 2014
    Date of Patent: November 19, 2019
    Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Robert E. Cohen, Michael F. Rubner, Gareth H. McKinley, George Barbastathis, Hyungryul Johnny Choi, Kyu Chul Park, Hyo Min Lee
  • Patent number: 10480281
    Abstract: A composition includes an aqueous colloidal dispersion of a nanomaterial. The nanomaterial includes, disposed on a surface of the nanomaterial, a first coupling agent including silane and a functional group including an amino acid. The nanomaterial includes, disposed on the surface of the nanomaterial, a second coupling agent including silane and a polymer with a molecular weight between 1,000 and 20,000.
    Type: Grant
    Filed: November 14, 2017
    Date of Patent: November 19, 2019
    Assignees: SAUDI ARABIAN OIL COMPANY, MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Abeer Mohammad Saleh Al-Olayan, Alfredo Alexander-Katz, Jason R. Cox
  • Patent number: 10482146
    Abstract: Exemplary embodiments include a system and method for Automatic Customization of Content Filtering (ACCF). The method includes receiving a search string from a user, creating a first filter based on the search string and searching different types of content stored in different content locations based on the first filter. The search returns a first subset of results to the user based on the first filter. The method further receives an indication of relevance for each one of the results in the first subset from the user. The method dynamically creates a second filter based on the received indications of relevance for the first subset of results. Based on the second filter, a second subset of more relevant results is returned to the user.
    Type: Grant
    Filed: May 10, 2017
    Date of Patent: November 19, 2019
    Assignee: Massachusetts Institute of Technology
    Inventors: Jason R. Thornton, Marianne A. Deangelus, Benjamin Andrew Miller, Kevin Kyung Nam