Abstract: A feed of at least one of (a) a source liquid including a solvent with a dissolved impurity and (b) a retentate of the source liquid is pumped in a substantially closed loop through a liquid-separation module. The liquid-separation module includes a membrane that passes at least partially purified solvent to a permeate side of the membrane while diverting the impurity in a retentate on the retentate side of the membrane. The purified solvent is extracted from the permeate side of the membrane; and the retentate from the liquid-separation module is pumped to or through a pressurized reservoir with a variable volume for the feed component and recirculated as a component of the feed. Over time, the volume for the feed is reduced and the pressure applied to the feed in the reservoir is increased to balance against an increasing difference in osmotic pressure across the membrane.

Abstract: A conventional flow tube for a metabolic cart is usually a straight length of pipe whose inner diameter is fixed by the respiratory burden imposed by the flow tube on the user, with a smaller diameter imposing a higher respiratory burden. The ratio of the straight flow tube's length to diameter is fixed by fluid dynamics, so increasing the flow tube's diameter causes the flow tube's length to increase. As the flow tube gets longer, it exerts more torque on the user's neck and jaw, creating discomfort. Reducing the flow tube's length causes an undesired increase in the respiratory burden but increasing the flow tube's diameter to reduce the respiratory burden makes the flow tube less comfortable, making the flow tube unconformable, hard to breathe through, or both. Bending the flow tube, e.g., in an L shape, makes it possible to increase the flow tube's propagation length without increasing the flow tube's lever arm length.

Abstract: Since the fat content of pork is a deciding factor in grading the quality of meat, the use of a noninvasive subcutaneous probe for real-time, in situ monitoring of the fat components is of importance to vendors and other interested parties. Fortunately, in situ, in vivo monitoring of subcutaneous fat can be accomplished with spatially offset Raman spectroscopy (SORS) using a fiber-optic probe. The probe acquires Raman spectra as a function of spatial offset. These spectra are used to determine the relative composition of fat-to-skin. The Raman intensity ratio varies disproportionately depending on the fat content, with variations in slope that are correlated to the thickness of the fat layer. Ordinary least square (OLS) regression using two components indicates that depth-resolved SORS spectra reflect the relative thickness of the fat layer.

Abstract: Provided herein are branched poly(beta-amino esters) (PBAE) useful as vehicles for the delivery of therapeutic agents, such as nucleic acids. The disclosed polymers form stable compositions, and are suitable for the delivery of therapeutic agents via nebulization. Compositions of the disclosed polymers are capable of delivering therapeutic agents such as mRNA to lung epithelial cells.

Abstract: A surface with selective wetting properties is described.

Abstract: An electro-mechanical device includes a payload of a magnet affixed to a mirror, and a coil assembly. The coil assembly has a body with wound electrically conducting wires and a payload aperture through which the payload travels. When voltage is applied to the coil assembly, current through the coil assembly generates a magnetic field resulting in a net upward force on the magnet that accelerates the payload to travel upward through the payload aperture for the mirror to block an optical pulse. As the magnet travels through the payload aperture, due to a magnetization direction of the magnet and a magnetic field in an upper portion of the coil assembly, the magnet experiences a net deceleration force that arrests the payload.

Abstract: A learning device calculates an image feature using a model (image encoder) that receives an image and outputs the image feature obtained by mapping the image into a latent space. The learning device calculates an audio feature using a model (audio encoder) that receives a speech in a predetermined language and outputs the audio feature obtained by mapping the speech into the latent space, and that includes a neural network provided with a self-attention mechanism. The learning device updates parameters of the models used by an image feature calculation unit and an audio feature calculation unit such that the image feature of a first image is similar to the audio feature of a speech corresponding to the first image.

Abstract: Catalytic compositions and sequential catalytic methods are generally described. in some embodiments, a composition comprises a first catalyst comprising a Cu-modified zeolite, and a second catalyst capable of a coupling reaction between (a) an intermediate resulting from a reaction of a reactant at the first catalyst, and (b) a co-reagent, wherein a rate of diffusion of the co-reagent within one or more cages and/or pores of the first catalyst is lower than a rate of diffusion of the intermediate within the one or more cages and/or pores of the first catalyst.

Abstract: Provided herein are methods for treating a neurodevelopmental disorder using a group II metabotropic glutamate receptor modulator.

Abstract: Barocaloric heat transfer systems and related methods are generally described. In some embodiments, a heat transfer system may include a barocaloric material which may generate heat upon compression and may cool down upon decompression. The barocaloric material may be pressurized using high pressure and low pressure fluids, which may, in some embodiments, also transfer heat to/from the barocaloric material. The heat transfer system may also include a hot heat exchanger to dissipate heat from the heat transfer system to a first environment and a cold heat exchanger to absorb heat from a second environment, effectively cooling the second environment. In some embodiments, the barocaloric material may be in particulate form.

Abstract: A learning device calculates a feature of each data included in a pair of datasets in which two modalities among a plurality of modalities are combined, using a model that receives data on a corresponding modality among the modalities and outputs a feature obtained by mapping the received data into an embedding space. The learning device then selects similar data similar to each target data that is data on a first modality in a first dataset of the datasets, from data on a second modality included in a second dataset of the datasets. The learning device further updates a parameter of the model such that the features of the data in the pair included in the first and the second datasets are similar to one another, and the feature of data paired with the target data is similar to the feature of data paired with the similar data.

Abstract: Methods and apparatus for extracting one or more mechanical properties for a material based on one or more indentation parameters for the material. The method comprises receiving load-displacement data from one or more instrumented indentation tests on the material, determining, by at least one computer processor, the indentation parameters for the material based, at least in part, on the received load-displacement data, providing as input to a trained neural network, the indentation parameters for the material, determining, based on an output of the trained neural network, the one or more mechanical properties of the material, and displaying an indication of the determined one or more mechanical properties of the material to a user of the computer system.

Abstract: The present disclosure relates to, inter alia, compounds (e.g., antibodies, or antigen-binding fragments thereof) that bind to an epitope of CD161 an inhibit the interaction between CD161 and CLEC2D, and the use of the compounds in methods for treating, or ameliorating one or more symptoms of, cancer.

Abstract: Methods and compositions for inducing a plurality of mutations in transgenic Cas9 eukaryotes to model a neuronal disease or disorder. The invention further comprehends testing putative treatments with such models, e.g., testing putative chemical compounds that may be pharmaceutically relevant for treatment or gene therapy that may be relevant for treatment, or combinations thereof. The invention allows for the study of genetic diseases and putative treatments to better understand and alleviate a genetic disease or a condition, e.g., autism, autism-spectrum disease or disorder, obsessive-compulsive disorder, or psychiatric disorders.

Abstract: Systems and techniques described herein include jointly decoding coded data of different codes, including different coding algorithms, finite fields, and/or source blocks sizes. The techniques described herein can be used to improve existing distributed storage systems by allowing gradual data migration. The techniques can further be used within existing storage clients to allow application data to be stored within diverse different distributed storage systems.

Abstract: The present invention provides methods for uniform growth of nanostructures such as nanotubes (e.g., carbon nanotubes) on the surface of a substrate, wherein the long axes of the nanostructures may be substantially aligned. The nanostructures may be further processed for use in various applications, such as composite materials. For example, a set of aligned nanostructures may be formed and transferred, either in bulk or to another surface, to another material to enhance the properties of the material. In some cases, the nanostructures may enhance the mechanical properties of a material, for example, providing mechanical reinforcement at an interface between two materials or plies. In some cases, the nanostructures may enhance thermal and/or electronic properties of a material. The present invention also provides systems and methods for growth of nanostructures, including batch processes and continuous processes.

Abstract: Provided herein are lipidoid compounds of Formulae (I) and (II), and pharmaceutically acceptable salts, co-crystals, tautomers, stereoisomers, solvates, hydrates, polymorphs, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the inventive lipidoid compounds, compositions, or formulations for treating and/or preventing diseases (e.g., genetic disease, proliferative disease, hematological disease, neurological disease, painful condition, psychiatric disorder, metabolic disorder, long-term medical condition, inflammatory disease, autoinflammatory disease, liver disease, lung disease, spleen disease, familial amyloid neuropathy, cardiovascular disease, viral infection, infectious disease, fibrotic condition, or autoimmune disease) in a subject, methods for synthesizing the compounds described herein, and compounds described herein synthesized by the synthetic methods described herein.

Abstract: Described are CMOS-compatible protonic resistive devices (e.g., processing elements and/or memory elements). In embodiments, a protonic resistive memory can be formed from a proton-sensitive metal oxide channel where the concentration of protons intercalated inside the layer is controlled to modulate its conductivity. The protons can initially be supplied to the material stack by an implantation method. Irradiation techniques can be implemented to increase the concentration and conductivity of protons inside the materials. Some designs can put the active layer and reservoir in direct contact, creating an electrolyte-free device. Designs provide scalable solutions for full-scale Si-integration.

Abstract: Embodiments related to electrodes comprising composite mixtures and related devices (e.g., convection batteries), systems, and methods are disclosed.

Abstract: Described herein are mutations in the CH1/CL interface and CH3 constant regions of a bispecific antibody which facilitate heterodimerization and methods for the efficient production of bispecific antibodies. Also disclosed are therapeutic and diagnostic methods for using the antibodies.