Abstract: A method of nonblocking optical switching includes guiding a first optical beam from a first input to a first output via a first path through an optical switching fabric. The first path traverses a phase shifter disposed between a pair of cascaded Mach-Zehnder interferometers. The method also includes receiving a second optical beam for a second path intersecting with the first path through the optical switching fabric. The method also includes moving the first optical beam from the first path to a third path connecting the first input to the first output without intersecting the second path. The method also includes shifting a phase of the first optical beam, with the phase shifter, while moving the first optical beam from the first path to the third path to prevent the first optical beam from interfering with the second optical beam.

Abstract: A method and device for preferentially delivering a compound such as an antigen to the cytosol of an immune cell. The method comprises passing a cell suspension comprising the target immune cell through a microfluidic device and contacting the suspension with the compound(s) or payload to be delivered.

Abstract: Embodiments described herein provide materials and methods for the absorption or filtration of various species and analytes. In some cases, the materials may be used to remove or reduce the amount of a substance in vapor sample (e.g., cigarette smoke).

Abstract: A method of imaging a scene includes estimating multiple three-dimensional (3D) representations, each of which corresponds to a respective portion of the scene. Neighboring portions of the scene area are at least partially overlapping. Each 3D representation is estimated by illuminating the respective portion of the scene with a light burst including multiple light pulses, after which multiple point clouds are generated by detecting photons reflected or scattered from the respective portion of the scene using a focal plane array. Data points in the point clouds represent a distance between the focal plane array and a scene point in the respective portion of the scene. The 3D representation is then estimated based on the multiple point clouds via coincidence processing. The method then generates a 3D image of the scene based on the multiple 3D representations.

Abstract: Exemplary embodiments relate to a skin-adherable electronic device including a semiconductor circuit unit including a circuit element including an electrode and an interconnect, and a semiconductor device including an insulating layer and an active layer; and a flexible patch that can adhere to skin and including a plurality of through-holes, wherein the insulating layer includes a plurality of through-holes corresponding to the plurality of through-holes of the flexible patch, and a method of manufacturing the same. When the active layer is made of a piezoelectric material, the electronic device may be used as a skin sensor that can acquire skin deformation and/or elasticity information.

Abstract: The present invention provides compositions and methods for delivery of therapeutic agents across an barrier. The compositions include a therapeutic agent (e.g., antimicrobial agent, antibiotic, or anesthetic agent), a permeation enhancer which increases the flux of the therapeutic agent across the barrier, and a matrix forming agent. The matrix forming agent forms a gel at a suitable gelation temperature and rheological properties for use in drug delivery, and in some cases, the gelation temperature and rheological properties are not significantly changed from those of the composition without the permeation enhancer. The invention also provides a matrix forming agent and compositions thereof. Such compositions are particularly useful in the treatment of otitis media. Methods of treatment, methods of delivery, and kits for the compositions described herein are also provided.

Abstract: The present invention provides processes for producing porous silk fibroin scaffold material. The porous silk fibroin scaffold can be used for tissue engineering. The porosity of the silk fibroin scaffolds described herein can be adjusted as to mimic the gradient of densities found in natural tissue. Accordingly, methods for engineering of 3-dimensional tissue, e.g. bone and cartilage, using the silk fibroin scaffold material are also provided.

Abstract: Quantum circuits and methods load N=2n classical bits into an entangled quantum output state using a gate depth of order O(n). Loading is accomplished by dividing the 2n input bits into data words and entangling these data words using ancilla qubits. The output of the circuit consists of one data word and one or several index qubits, drawn from the ancilla, to select between the input data words. Entanglement of the data words is performed in a single time slice (i.e. with a gate depth of 1), while the number of sequential gates needed to produce the appropriate pre-entanglement quantum state in the ancilla, and to disentangle the non-output ancilla, has the desired order O(n). Also disclosed is a circuit for disentangling qubits used to store non-output data words during processing.

Abstract: Flow through reactors and related methods for use with slurries including water reactive particles are generally described.

Abstract: Provided herein are methods and systems for amplifying and/or detecting target double-stranded or single-stranded nucleic acids. The methods comprise combining a sample comprising the target nucleic acid with an amplification reaction mixture, amplifying the target nucleic acid, and further amplifying the target nucleic acid by repeated opening, unwinding, annealing and extension under isothermal conditions. The amplification reaction mixture may include an amplification CRISPR system, a helicase, a primer pair, and a polymerase. The amplification CRISPR system may comprise a first and second CRISPR/Cas complex, the first and second CRISPR/Cas complex may comprise a first CRISPR/Cas enzyme and a first guide molecule that guides the first CRISPR/Cas complex to a first strand of the target nucleic acid; the second CRISPR/Cas complex may comprise a second CRISPR/Cas enzyme and a second guide molecule that guides the second CRISPR/Cas complex to a second strand of the target nucleic acid.

Abstract: The invention provides for delivery, engineering and optimization of systems, methods and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery systems and tissues or organ which are targeted as sites for delivery. Also provided are vectors and vector systems some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity and to edit or modify a target site in a genomic locus of interest to alter or improve the status of a disease or a condition.

Abstract: A metal-halo oxyanion electrode and battery including the metal-halo oxyanion electrode is described.

Abstract: The embodiments disclosed herein utilized RNA targeting effectors to provide a robust CRISPR-based diagnostic with attomolar sensitivity. Embodiments disclosed herein can detect broth DNA and RNA with comparable levels of sensitivity and can differentiate targets from non-targets based on single base pair differences. Moreover, the embodiments disclosed herein can be prepared in freeze-dried format for convenient distribution and point-of-care (POC) applications. Such embodiments are useful in multiple scenarios in human health including, for example, viral detection, bacterial strain typing, sensitive genotyping, and detection of disease-associated cell free DNA.

Abstract: A solid electrolyte material is of the formula A7±2xP3X((11±x)?y)Oy wherein wherein A is Li or Na, wherein X is S, Se, or a combination thereof, provided that when M is Li, X is Se, and wherein 0?x?0.25 and 0?y?2.5. Also, an electrochemical cell including the solid electrolyte material, and methods for the manufacture of the solid electrolyte material and the electrochemical cell.

Abstract: Robotic devices and methods for performing minimally invasive procedures on the vascular system, particularly cerebrovascular and endovascular neurosurgical procedures, where a submillimeter-scale continuum robotic device is configured and adapted for active steering and navigation based on external magnetic actuation. The submillimeter-scale continuum robotic device includes an elongate body having an inner core and an outer shell, where the outer shell is fabricated of an elastomeric material having a plurality of ferromagnetic particles dispersed therein.

Abstract: A decoder comprises a feature extraction circuit for calculating one or more feature vectors; an acoustic model circuit coupled to receive one or more feature vectors from said feature extraction circuit and assign one or more likelihood values to the one or more feature vectors; a memory for storing states of transition of the decoder; and a search circuit for receiving an input from said acoustic model circuit corresponding to the one or more likelihood values based upon the one or more feature vectors, and for choosing states of transition from the memory based on the input from said acoustic model.

Abstract: A long sheet may travel lengthwise through a fabrication system. The sheet may be much longer than it is wide or high. One or more objects that are being fabricated may be attached to the sheet. The sheet may move, step by step, through a vat of liquid photopolymer while a digital micromirror device projects a sequence of images unto a surface of the liquid. At each step, a projected light image may cure liquid photopolymer, thereby producing solid, cured polymer that becomes part of an object being fabricated. The sheet may be included in the final fabricated object, or may be a sacrificial material that is removed from the final fabricated object. Alternatively, the sheet may be in the shape of a loop. Or, the sheet may be detached from the final fabricated object and then fed through the system again.

Abstract: Stimulated Brillouin scattering (SBS) limits the maximum power in fiber lasers with narrow linewidths. SBS occurs when the power exceeds a threshold proportional to the beam area divided by the effective fiber length. The fiber lasers disclosed here operate with higher SBS power thresholds (and hence higher maximum powers at kilohertz-class linewidths) than other fiber lasers thanks to several techniques. These techniques include using high-absorption gain fibers, operating the laser with low pump absorption (e.g., ?80%), reducing the length of un-pumped gain fiber at the fiber output, foregoing a delivery fiber at the output, foregoing a cladding light stripper at the output, using free-space dichroic mirrors to separate signal light from unabsorbed pump light, and using cascaded gain fibers with non-overlapping Stokes shifts. The upstream gain fiber has high absorption and a larger diameter for high gain, and subsequent gain fiber has a smaller diameter to improve beam quality.

Abstract: Summarization of an input story can be accomplished through identification of causal relationships, both explicit and implicit. The input story is transformed into an interpretation sequence, using syntactic cues, and common sense knowledge of an average reader. The interpretation sequence is a time ordered semantic representation of the input story, comprised of story elements. The common sense knowledge includes inference rules, which, from story elements already present, can add additional story elements to the interpretation sequence. Application of inference rules, based on type, can be prioritized. Summarization of the interpretation sequence can be accomplished by the selection of explicit story elements, according to a connection-based strategy, or a concept-based strategy. Regarding a concept-based strategy, metrics can be applied, to select the concepts for contra-causal searching of the interpretation sequence.

Abstract: A waveguide-coupled Silicon Germanium (SiGe) photodetector. A p-n silicon junction is formed in a silicon substrate by an n-doped silicon region and a p-doped silicon region, a polysilicon rib is formed on the silicon substrate to provide a waveguide core for an optical mode of radiation, and an SiGe pocket is formed in the silicon substrate along a length of the polysilicon rib and contiguous with the p-n silicon junction. An optical mode of radiation, when present, substantially overlaps with the SiGe pocket so as to generate photocarriers in the SiGe pocket. An electric field arising from the p-n silicon junction significantly facilitates a flow of the generated photocarriers through the SiGe pocket. In one example, such photodetectors have been fabricated using a standard CMOS semiconductor process technology without requiring changes to the process flow (i.e., “zero-change CMOS”).