Patents Assigned to Massachusetts Institutes of Technology
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Publication number: 20240117365Abstract: The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for selecting specific cells by introducing precise mutations utilizing the CRISPR/Cas system.Type: ApplicationFiled: August 23, 2023Publication date: April 11, 2024Applicants: The Broad Institute, Inc., Massachusetts Institute of TechnologyInventor: Feng Zhang
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Publication number: 20240118537Abstract: Provided herein is a photonic integrated circuit and methods for controlling a photonic integrated circuit that can utilize the resonant frequency of one or more components of the photonic integrated circuit to enhance the response of the circuit. At least one component of the photonic integrated circuit can be driven by an electrical signal whose frequency is substantially equal to the mechanical resonance frequency of the component such that the response of the optical component is increased. The component of the photonic integrated circuit can include a phase shifter that can impart a phase shift on a received optical signal. By driving the phase shifter with an electrical signal that is equal to the mechanical resonance frequency of the optical phase shifter, less power can be required to impart a desired phase shift on a received optical signal. The optical components can be implemented using piezoelectric cantilevers.Type: ApplicationFiled: October 4, 2023Publication date: April 11, 2024Applicants: The MITRE Corporation, Sandia National Laboratories, MIT - Massachusetts Institute of TechnologyInventors: Mark DONG, Gerald Neal GILBERT, Matthew Scott EICHENFIELD, Dirk Robert ENGLUND
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Patent number: 11953439Abstract: The present invention generally relates to the generation of tunable coloration and/or interference from, for example, surfaces, emulsion droplets and particles. Embodiments described herein may be useful for generation of tunable electromagnetic radiation such as coloration (e.g., iridescence, structural color) and/or interference patterns from, for example, surfaces (e.g., comprising a plurality of microdomes and/or microwells), emulsion droplets and/or particles. In some embodiments, the surfaces, interfaces, droplets, and/or particles produce visible color (e.g., structural color) without the need for dyes.Type: GrantFiled: August 16, 2019Date of Patent: April 9, 2024Assignees: Massachusetts Institute of Technology, The Penn State Research FoundationInventors: Lauren Dell Zarzar, Sara N. Nagelberg, Mathias Kolle, Amy Goodling
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Patent number: 11951672Abstract: Methods of manufacturing multi-material fibers having one or more electrically-connectable devices disposed therein are described. In certain instances, the methods include the steps of: positioning the electrically-connectable device(s) within a corresponding pocket provided in a preform material; positioning a first electrical conductor longitudinally within a first conduit provided in the preform material; and drawing the multi-material fiber by causing the preform material to flow, such that the first electrical conductor extends within the multi-material fiber along a longitudinal axis thereof and makes an electrical contact with a first electrode located on each electrically-connectable device. A metallurgical bond may be formed between the first electrical conductor and the first electrode while drawing the multi-material fiber and/or, after drawing the multi-material fiber, the first electrical conductor may be located substantially along a neutral axis of the multi-material fiber.Type: GrantFiled: April 21, 2021Date of Patent: April 9, 2024Assignees: Advanced Functional Fabrics of America, Inc., Massachusetts Institute of TechnologyInventors: Chia-Chun Chung, Jason Cox, Kristina McCarthy, Kristen Mulherin, Jimmy Nguyen, Michael Rein, Matthew Bernasconi, Lauren Cantley, Lalitha Parameswaran, Michael Rickley, Alexander Stolyarov
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Patent number: 11953482Abstract: Methods of sensing carbon dioxide, sensors, and related articles and systems are generally described.Type: GrantFiled: April 16, 2020Date of Patent: April 9, 2024Assignee: Massachusetts Institute of TechnologyInventors: Mircea Dinca, Ivo Stassen, Jinhu Dou
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Patent number: 11952571Abstract: This disclosure provides systems, methods, and compositions for site-specific genetic engineering using Programmable Addition via Site-Specific Targeting Elements (PASTE). PASTE comprises the addition of an integration site into a target genome followed by the insertion of one or more genes of interest or one or more nucleic acid sequences of interest at the site. PASTE combines gene editing technologies and integrase technologies to achieve unidirectional incorporation of genes in a genome for the treatment of diseases and diagnosis of disease.Type: GrantFiled: October 16, 2023Date of Patent: April 9, 2024Assignee: Massachusetts Institute of TechnologyInventors: Omar Abudayyeh, Jonathan Gootenberg
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Patent number: 11954910Abstract: Methods, apparatus, and systems for multi-resolution processing for video classification. A plurality of video frames of a video are obtained and a resolution for classifying each video frame of the plurality of video frames is determined by analyzing each video frame using a policy network. Based on the determined resolution, each video frame having a determined resolution is rescaled and each rescaled video frame is routed to a classifier of a backbone network that corresponds to the determined resolution. Each rescaled video frame is classified using the corresponding classifier of the backbone network to obtain a plurality of classifications and the classifications are averaged to determine an action classification of the video.Type: GrantFiled: December 26, 2020Date of Patent: April 9, 2024Assignees: International Business Machines Corporation, MASSACHUSETTS INSTITUTE OF TECHNOLOGY, MAInventors: Rameswar Panda, Yue Meng, Chung-Ching Lin, Rogerio Schmidt Feris, Aude Jeanne Oliva
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Patent number: 11953836Abstract: A reticle transport system having a magnetically levitated transportation stage is disclosed. Such a system may be suitable for use in vacuum environments, for example, ultra-clean vacuum environments. A magnetic levitated linear motor functions to propel the transportation stage in a linear direction along a defined axis of travel and to magnetically levitate the transportation stage.Type: GrantFiled: March 7, 2022Date of Patent: April 9, 2024Assignees: Massachusetts Institute of Technology, ASML Netherlands B.V.Inventors: Lei Zhou, David L. Trumper, Ruvinda Gunawardana
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Patent number: 11956017Abstract: A spectrally multiplexed quantum repeater (SMuQR) based on spatially arrayed nodes of frequency-multiplexed multi-qubit registers uses the natural inhomogeneous distribution of optical transition frequencies in solid state defect centers. This distribution enables spectrally selective, individual addressing of large numbers of defect centers within an optical diffraction limited spot along a long cavity or waveguide. The spectral selection relies on frequency shifting an incident optical field at a rate as fast as once per defect center lifetime. The defect centers are resonant at visible frequencies and emit visible single photons which are down-converted to a wavelength compatible with long-distance transmission via conventional optical fiber. The down-converted photons are all at the same telecommunications wavelength, with the different spectral bins mapped to different temporal bins to preserve the multiplexing in the time domain, for distribution to other nodes in the quantum network.Type: GrantFiled: August 26, 2021Date of Patent: April 9, 2024Assignee: Massachusetts Institute of TechnologyInventors: Eric Alexander Bersin, Carlos Errando Herranz, Dirk Robert Englund
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Publication number: 20240108241Abstract: Drug delivery articles, resident articles, and retrieval systems e.g., for gram-level dosing, are generally provided. In some embodiments, the residence articles are configured for transesophageal administration, transesophageal retrieval, and/or gastric retention to/in a subject. In certain embodiments, the residence article includes dimensions configured for transesophageal administration with a gastric resident system. In some cases, the residence article may be configured to control drug release e.g., with zero-order drug kinetics with no potential for burst release for weeks to months. In some embodiments, the residence articles described herein comprise biocompatible materials and/or are safe for gastric retention. In certain embodiments, the residence article includes dimensions configured for transesophageal retrieval. In some cases, the residence articles described herein may comprise relatively large doses of drug (e.g., greater than or equal to 1 gram).Type: ApplicationFiled: December 15, 2023Publication date: April 4, 2024Applicants: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc., The General Hospital CorporationInventors: Robert S. Langer, Carlo Giovanni Traverso, Malvika Verma, Feyisope Eweje, Christoph Winfried Johannes Steiger, Junwei Li, Nhi Phan, Hen-Wei Huang, Jacqueline Chu, John Ashraf Fou Salama
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Publication number: 20240110614Abstract: An orbital tensile drive is herein disclosed, along with systems and methods associated therewith. The orbital tensile drive uses a tensile element that is conveyed around a static, fixed shaft and a rotating output shaft. This is facilitated via multiple orbiting idler pulleys that are mounted to an orbiter body. The static and rotating shafts, as well as the orbiting assembly, share a common axis. Input rotation to the orbiter body is transformed into lower-speed, higher-torque rotation at the rotating output shaft. The present invention has many potential applications including, but not limited to, robotics.Type: ApplicationFiled: September 26, 2023Publication date: April 4, 2024Applicant: Massachusetts Institute of TechnologyInventor: Jake Robert Read
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Publication number: 20240110238Abstract: As described below, disclosed herein are methods of analyzing DNA methylation in cell-free DNA (cfDNA) and genomic DNA (gDNA) from sequencing data.Type: ApplicationFiled: September 8, 2023Publication date: April 4, 2024Applicants: The Broad Institute, Inc., Massachusetts Institute of TechnologyInventors: Yaping LIU, Manolis KELLIS, Viktor ADALSTEINSSON, Zhizhuo ZHANG
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Patent number: 11948704Abstract: Techniques described herein relate to systems and methods for obtaining a high temperature superconducting (HTS) cable assembly and filling the HTS cable assembly with a molten metal, such as solder.Type: GrantFiled: November 12, 2020Date of Patent: April 2, 2024Assignee: Massachusetts Institute of TechnologyInventors: Amanda Hubbard, James Irby, Rui Vieira, William Beck, Richard Murray, Andrew Pfeiffer, Thomas Toland, William Burke
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Patent number: 11945737Abstract: Various aspects described herein relate to electrochemical devices, e.g., for separation of one or more target organic or inorganic molecules (e.g., charged or neutral molecules) from solution, and methods of using the same. In particular embodiments, the electrochemical devices and methods described herein involve at least one redox-functionalized electrode, wherein the electrode comprises an immobilized redox-species that is selective toward a target molecule (e.g., charged molecule such as ion or netural molecule). The selectivity is based on a Faradaic/redox-activated chemical interaction (e.g., directional hydrogen binding) between the oxidized state of the redox species and a moiety of the target molecule (e.g., charged molecule such as ion or netural molecule).Type: GrantFiled: July 6, 2020Date of Patent: April 2, 2024Assignee: Massachusetts Institute of TechnologyInventors: Xiao Su, Demetra S. Achilleos, Trevor Alan Hatton
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Patent number: 11946162Abstract: The invention relates to methods and products for generating diverse libraries of genetic material. The products include libraries and constructed nucleic acids as well as kits and databases and systems thereof.Type: GrantFiled: March 17, 2021Date of Patent: April 2, 2024Assignee: Massachusetts Institute of TechnologyInventors: Dehua Zhao, Christopher A. Voigt, Michael Joseph Smanski
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Publication number: 20240101620Abstract: Glycan-binding proteins, and compositions thereof, are generally described, including methods of making and using such proteins. The proteins may include scaffolds based on easily evolvable DNA-binding proteins, with binding sites able to specifically bind to mono- or disaccharides, such as monosaccharide-binding determinants, disaccharide-binding determinants, more complex carbohydrates, etc. In certain aspects, a protein may be generated starting from a small DNA-binding protein, such as Sso7d. Such glycan-binding proteins may have numerous applications, including in enzyme-linked immunosorbent assays (ELISAs), glycan characterization, cell selection, flow cytometry, histology, imaging, arrays, affinity purification, enzyme-linked visualization, binding to a target for pharmaceutical purposes, etc.Type: ApplicationFiled: January 26, 2023Publication date: March 28, 2024Applicant: Massachusetts Institute of TechnologyInventors: Barbara Imperiali, Cristina Zamora, Elizabeth Ward
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Patent number: 11939637Abstract: In one aspect, provided herein is a method comprising: (a) (i) determining cytolytic activity in a tumor from the subject; and/or (ii) determining genetic alterations associated with cytolytic activity in the tumor; and (b) administering an immunotherapeutic agent to the subject if (i) cytolytic activity is detected in the tumor and/or (ii) a genetic alteration associated with induction of cytolytic activity, tumor resistance to cytolytic activity and/or suppression of cytolytic activity is detected in the tumor.Type: GrantFiled: February 19, 2021Date of Patent: March 26, 2024Assignees: Massachusetts Institute of Technology, The General Hospital CorporationInventors: Nir Hacohen, Michael S. Rooney
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Patent number: 11942898Abstract: Described are concepts, systems, circuits and techniques directed toward methods and apparatus for generating one or more pulse width modulated (PWM) waveforms with the ability to dynamically control pulse width and phase with respect to a reference signal.Type: GrantFiled: March 24, 2022Date of Patent: March 26, 2024Assignee: Massachusetts Institute of TechnologyInventors: Alexander Sergeev Jurkov, David J. Perreault
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Patent number: 11940580Abstract: A system for near-surface geophysical subsurface imaging for detecting and characterizing subsurface heterogeneities comprises an instrument that outputs probing electromagnetic signals through a ground surface that interact and are affected by scattered signals of acoustic waves that travel through the ground surface and further senses vibrational modes of a subsurface below the ground surface; an imaging device that dynamically generates a time sequence of images of properties of the acoustic waves and maps elastic wave fields of the acoustic waves; and a processor that analyzes dynamic multi-wave data of the images to quantify spatial variations in the mechanical and viscoelastic properties of the subsurface.Type: GrantFiled: October 10, 2019Date of Patent: March 26, 2024Assignees: Massachusetts Institute of Technology, The Trustees of Boston UniversityInventors: Stephen Brown, Thomas Szabo, Daniel R. Burns, Michael Fehler
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Patent number: 11939408Abstract: Skin hydration is necessary to maintain the epidermal barrier, minimize adverse environmental influences, and reduce cell stress. Provided herein are compounds, such as compounds of Formula (I), and pharmaceutically and cosmetically acceptable salts thereof, and compositions, methods, and uses that may be used for skin hydration. Also reported herein is a scalable method for synthesizing compounds of Formula (I). The compounds provided herein are responsible for improved skin penetration and/or retention and are therefore useful for the treatment and/or prevention of various diseases, disorders, or conditions to protect human skin.Type: GrantFiled: December 18, 2020Date of Patent: March 26, 2024Assignee: Massachusetts Institute of TechnologyInventors: Bradley David Olsen, Allie Obermeyer, Sieun Kim Barnes, Yun Jung Yang