Abstract: Aspects of the present application relate to techniques of diagnosing whether a pathogen (e.g., SARS-CoV-2) is present in a subject using infrared (IR) spectroscopy and machine learning techniques. The techniques use spectral data obtained from performing IR spectroscopy on a biological sample (e.g., saliva or nasal sample, or genetic material extracted therefrom) to generate a set of feature values. The feature values are provided as input to a machine learning model to obtain output indicating whether the pathogen is present in the biological sample. The output of the machine learning model may be used to determine a diagnosis result for a subject.

Abstract: Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface. The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage with a surface. In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components.

Abstract: Methods and apparatus for non-intrusive monitoring by sensing physical parameters such as electric and/or magnetic fields.

Abstract: Self-regulating valve. The valve includes a static pressure chamber with an elastically collapsible tube supported within the static pressure chamber. A flow restrictor is in fluid communication with an inlet into the static pressure chamber for flow through the collapsible tube. Piping connects a source of pressurized liquid, both to the flow restrictor and to an opening into the static pressure chamber, whereby flow rate through the valve remains substantially constant with variations in pressure of the pressurized liquid. In a preferred embodiment, the flow restrictor is a needle valve.

Abstract: An active three-terminal superconducting device having an intersection region at which a hot spot may be controllably formed is described. The intersection region may exhibit current crowding in response to imbalances in current densities applied to channels connected to intersection region. The current crowding may form a hot spot, in which the superconducting device may exhibit a measurable resistance. In some cases, a three-terminal superconducting device may be configured to sense an amount of superconducting current flowing in a channel or loop without having to perturb the superconducting state or amount of current flowing in the channel. A three-terminal superconducting device may be used to read out a number of fluxons stored in a superconducting memory element.

Abstract: Embodiments described herein provide functionalized carbon nanostructures for use in various devices, including photovoltaic devices (e.g., solar cells). In some cases, the carbon nanostructures are fullerenes substituted with one or more isobenzofulvene species and/or indane species. Devices including such materials may exhibit increased efficiency, increased open circuit potential, high electron/hole mobility, and/or low electrical resistance.

Abstract: Double-stranded RNA (dsRNA) induces sequence-specific post-transcriptional gene silencing in many organisms by a process known as RNA interference (RNAi). Using a Drosophila in vitro system, we demonstrate that 19-23 nt short RNA fragments are the sequence-specific mediators of RNAi. The short interfering RNAs (siRNAs) are generated by an RNase III-like processing reaction from long dsRNA. Chemically synthesized siRNA duplexes with overhanging 3? ends mediate efficient target RNA cleavage in the lysate, and the cleavage site is located near the center of the region spanned by the guiding siRNA. Furthermore, we provide evidence that the direction of dsRNA processing determines whether sense or antisense target RNA can be cleaved by the produced siRNP complex.

Abstract: The effective ionic conductivity in a composite structure is believed to decrease rapidly with volume fraction. A system, such as a bipolar device or energy storage device, has structures or components in which the diffusion length or path that electrodes or ions must traverse is minimized and the interfacial area exposed to the ions or electrons is maximized. The device includes components that can be reticulated or has a reticulated interface so that an interface area can be increased. The increased interfacial perimeter increases the available sites for reaction of ionic species. Many different reticulation patterns can be used. The aspect ratio of the reticulated features can be varied. Such bipolar devices can be fabricated by a variety of methods or procedures. A bipolar device having structures of reticulated interface can be tailored for the purposes of controlling and optimizing charge and discharge kinetics.

Abstract: The invention relates to a method and apparatus for distributing a request to one of a plurality of resources. A request is mapped to a location in circular mapping space using a hash function. Each of the plurality of resources is mapped to a respective location or locations in the circular mapping space. The request is allocated to one of the resources based on the given request location and the resource location in the circular mapping space.

Abstract: A synthetic phase tuned multi-mode acoustic guided wave system and method activates at least one of a plurality of elements as a receiver or a transmitter and at least two of the elements as transmitters or receivers, respectively, and sequentially excites each of the transmitter elements for creating a train of acoustic guided waves which includes a selected mode, and shifts the acoustic guided waves of the selected mode sensed by the receivers by a period which is a function of the phase velocity of the selected mode and sums them to reinforce the selected mode.