Patents Assigned to Mast Therapeutics, Inc.
  • POLOXAMER COMPOSITION FREE OF LONG CIRCULATING MATERIAL AND METHODS FOR PRODUCTION AND USES THEREOF
    Publication number: 20170002141
    Abstract: Provided herein are long circulating material free (LCMF) poloxamer compositions and uses thereof. In particular, provided are LCMF poloxamer 188 compositions and uses thereof. Also provided are supercritical fluid extraction (SFE) methods and high pressure (subcritical) methods for preparing poloxamer compositions, particularly the LCMF poloxamer compositions.
    Type: Application
    Filed: July 11, 2016
    Publication date: January 5, 2017
    Applicant: MAST THERAPEUTICS, INC.
    Inventors: R. Martin EMANUELE, Mannarsamy BALASUBRAMANIAN, Stewart V. SMITH
  • DIURETIC INDUCED ALTERATIONS OF PLASMA VOLUME
    Publication number: 20160235781
    Abstract: Provided are uses of a poloxamer and methods of administering a poloxamer for treating hemo-concentration, such as hemo-concentration resulting from dehydration and/or diuresis in a subject. Administration of a poloxamer prevents, treats or otherwise reduces adverse effects of hemo-concentration, dehydration and/or diuresis.
    Type: Application
    Filed: October 16, 2014
    Publication date: August 18, 2016
    Applicant: MAST THERAPEUTICS, INC.
    Inventor: R. Martin EMANUELE
  • Poloxamer composition free of long circulating material and methods for production and uses thereof
    Patent number: 9403941
    Abstract: Provided herein are long circulating material free (LCMF) poloxamer compositions and uses thereof. In particular, provided are LCMF poloxamer 188 compositions and uses thereof. Also provided are supercritical fluid extraction (SFE) methods and high pressure (subcritical) methods for preparing poloxamer compositions, particularly the LCMF poloxamer compositions.
    Type: Grant
    Filed: July 7, 2015
    Date of Patent: August 2, 2016
    Assignee: Mast Therapeutics, Inc.
    Inventors: R. Martin Emanuele, Mannarsamy Balasubramanian, Stewart V. Smith
  • METHODS FOR ENHANCING OXYGENATION OF JEOPARDIZED TISSUE
    Publication number: 20150093368
    Abstract: The present invention provides methods for preventing the adverse effects of transfusing a patient with blood or blood products compromised by storage lesion. The methods include administering to a patient a pharmaceutical composition comprising an effective amount of a polyoxyethylene/polyoxypropylene copolymer and a pharmaceutically acceptable carrier. The safety and effectiveness of transfusing blood with storage lesion can be increased using the methods of the invention.
    Type: Application
    Filed: November 25, 2014
    Publication date: April 2, 2015
    Applicant: Mast Therapeutics, Inc.
    Inventor: R. Martin Emanuele
  • Low oil emulsion compositions for delivering taxoids and other insoluble drugs
    Patent number: 8557861
    Abstract: The present invention provides injectable oil-in-water emulsions of taxoid drugs or other water insoluble drugs. The present invention also provides methods for preparing and using such oil-in-water emulsions.
    Type: Grant
    Filed: September 28, 2004
    Date of Patent: October 15, 2013
    Assignee: Mast Therapeutics, Inc.
    Inventor: Andrew Xian Chen
  • Anti-viral pharmaceutical compositions
    Patent number: 8470346
    Abstract: The present invention provides antiviral compositions that comprise one or more of an ionic multivalent metal component, a cationic polymer, and a cationic surfactant. The present invention also provides methods for making and using such antiviral compositions.
    Type: Grant
    Filed: May 19, 2011
    Date of Patent: June 25, 2013
    Assignee: Mast Therapeutics, Inc.
    Inventor: Andrew Xian Chen
  • Vitamin E succinate stabilized pharmaceutical compositions, methods for the preparation and the use thereof
    Patent number: 8470873
    Abstract: The present invention provides vitamin E succinate (VES)-stabilized compositions, methods for the preparation thereof and methods useful for the in vivo delivery of substantially water insoluble and optionally chemically unstable pharmacologically active agents (such as docetaxel).
    Type: Grant
    Filed: February 1, 2007
    Date of Patent: June 25, 2013
    Assignee: Mast Therapeutics, Inc.
    Inventor: Andrew Xian Chen