Abstract: An intermediate bulk container (I.B.C.) system for handling a flowable material such as a pharmaceutical powder comprises, a discharge station, a transportable station for holding and transporting the powder, and a seal arrangement of the two stations, the seal arrangement being such that seals thereof cooperate one with the other and with the stations, whereby exposure of external surfaces of the system to the powder is obviated during discharge at the discharge station and during transport, so that no powder can escape from the interior to the exterior in use.