Abstract: A method of detection of nucleic acids from a biological sample without isolation or purification of the nucleic acids is described. The method may include direct detection of nucleic acids from humans, animals, viruses or bacteria, including DNA and RNA from a biological sample without isolating or purifying nucleic acids prior to analysis. Biological samples may be blood, urine, semen, tissue, swabs (nasal, buccal, ocular, vaginal or anal).

Abstract: A biological sample collection system and dispensing system is described. The biological sample collection system provides for collection and processing of a biological sample (i.e. bodily fluids collected from nose, throat, or other mucosal membrane of an animal or human). The biological sample collection system includes a sample collector and a collection tube. The sample collector provides a structure for sealing the biological sample in the collection tube for further processing without opening the collection tube, and may provide a structure for collecting the biological sample. When the sample collector and collection tube are removably attached the dispensing system is formed. The dispensing system provides for further processing of the biological sample without opening the collection tube (i.e. without un-securing or removing the plug from the collection tube). The dispensing system further provides dispensing of the processed biological sample without opening the collection tube).

Abstract: A capillary diagnostic device comprising a cylindrical tube with one or more rings having one or more probes, the one or more rings disposed on the interior surface of the cylindrical tube. The invention also includes a method of making the capillary diagnostic device and method of use thereof for diagnostic testing.