Patents Assigned to MATOKE HOLDINGS LIMITED
  • Patent number: 11730168
    Abstract: A composition has an enzyme that is able to convert a substrate to release hydrogen peroxide; a substrate for the enzyme; and a superabsorbent component, such as a superabsorbent polymer. The composition is in the form of a powder and may form a gel on contact with water.
    Type: Grant
    Filed: October 16, 2018
    Date of Patent: August 22, 2023
    Assignee: Matoke Holdings Limited
    Inventors: Thomas Hall, Sophie Constance Cox, Liam Michael Grover, David Kershaw
  • Publication number: 20220248689
    Abstract: Storage-stable compositions for generating antimicrobial activity are described. The compositions comprise an enzyme that is able to convert a substrate to release hydrogen peroxide, and an unrefined natural substance, such as a honey, that includes a substrate for the enzyme. In certain embodiments, the enzyme is a purified enzyme. In other embodiments, the substrate lacks catalase activity, and the enzyme is additional to any enzyme activity able to convert the substrate to release hydrogen peroxide that may be present in the unrefined natural substance. The storage-stable compositions do not include sufficient free water to allow the enzyme to convert the substrate. Use of the compositions to treat microbial infections and wounds is described, as well as methods for their production.
    Type: Application
    Filed: April 12, 2022
    Publication date: August 11, 2022
    Applicant: MATOKE HOLDINGS LIMITED
    Inventors: Thomas Patton, James Brennan, John Reginald Barrett, Ian Staples
  • Patent number: 11311017
    Abstract: Storage-stable compositions for generating antimicrobial activity are described. The compositions comprise an enzyme that is able to convert a substrate to release hydrogen peroxide, and an unrefined natural substance, such as a honey, that includes a substrate for the enzyme. In certain embodiments, the enzyme is a purified enzyme. In other embodiments, the substrate lacks catalase activity, and the enzyme is additional to any enzyme activity able to convert the substrate to release hydrogen peroxide that may be present in the unrefined natural substance. The storage-stable compositions do not include sufficient free water to allow the enzyme to convert the substrate. Use of the compositions to treat microbial infections and wounds is described, as well as methods for their production.
    Type: Grant
    Filed: April 30, 2014
    Date of Patent: April 26, 2022
    Assignee: MATOKE HOLDINGS LIMITED
    Inventors: Thomas Patton, James Brennan, John Reginald Barrett, Ian Staples
  • Patent number: 11185080
    Abstract: Storage-stable compositions for generating antimicrobial activity are described. The compositions comprise an enzyme that is able to convert a substrate to release hydrogen peroxide, and an unrefined natural substance, such as a honey, that includes a substrate for the enzyme. In certain embodiments, the enzyme is a purified enzyme. In other embodiments, the substrate lacks catalase activity, and the enzyme is additional to any enzyme activity able to convert the substrate to release hydrogen peroxide that may be present in the unrefined natural substance. The storage-stable compositions do not include sufficient free water to allow the enzyme to convert the substrate. Use of the compositions to treat microbial infections and wounds is described, as well as methods for their production.
    Type: Grant
    Filed: August 24, 2017
    Date of Patent: November 30, 2021
    Assignee: MATOKE HOLDINGS LIMITED
    Inventors: Thomas Patton, James Brennan, John Reginald Barrett, Ian Staples
  • Publication number: 20180023217
    Abstract: Fibers for generating antimicrobial activity are described. The fibers comprise an enzyme that is able to convert a substrate to release hydrogen peroxide, and an unrefined natural substance that includes a substrate for the enzyme, wherein the enzyme is additional to any enzyme activity able to convert the substrate to release hydrogen peroxide that may be present in the unrefined natural substance. In the presence of sufficient free water, the enzyme converts the substrate to release hydrogen peroxide, which is effective against a wide range of microbes. Wound dressings and compositions comprising the fibers are also described, as is use of the fibers, wound dressings and compositions, particularly for wound healing.
    Type: Application
    Filed: February 3, 2016
    Publication date: January 25, 2018
    Applicant: MATOKE HOLDINGS LIMITED
    Inventors: Thomas PATTON, James BRENNAN, Ian STAPLES, Iain ELDER, Annette CALLAGHAN, Matthew DRYDEN, John Reginald BARRETT, David KERSHAW, Rami SALIB