Abstract: A biomaterial, particularly for tissue regeneration, includes an open, porous bioresorbable first material portion and a second material portion that is stiffer than the first material portion, wherein the volume fraction of the stiffer material is less than 30% of the total volume of the biomaterial, and the structural stiffness of the second material portion is at least 10 times greater than that of the first material portion.
Type:
Grant
Filed:
June 28, 2017
Date of Patent:
January 17, 2023
Assignees:
MATRICEL GMBH, CHARITÉ - UNIVERSITAETSMEDIZIN BERLIN
Inventors:
Ingo Heschel, Hans Leemhuis, Georg Duda, Aarón Xerach Herrera Martín, Ansgar Petersen
Abstract: A biomaterial, particularly for tissue regeneration, includes an open, porous bioresorbable first material portion and a second material portion that is stiffer than the first material portion, wherein the volume fraction of the stiffer material is less than 30% of the total volume of the biomaterial, and the structural stiffness of the second material portion is at least 10 times greater than that of the first material portion.
Type:
Application
Filed:
June 28, 2017
Publication date:
June 11, 2020
Applicants:
Matricel GmbH, Charité - Universitaetsmedizin Berlin
Inventors:
Ingo HESCHEL, Hans LEEMHUIS, Georg DUDA, Aarón Xerach HERRERA MARTÍN, Ansgar PETERSEN
Abstract: In order to achieve a reproducible treatment for materials of biological origin such as membranes, skins, vessels, heart valves, tendons and ligaments and, in particular, collagen materials, hydrophobic accompanying substances are, first of all, chemically removed without the accompanying substances being chemically altered. Non-hydrophobic accompanying substances are subsequently removed. The materials treated in this manner are used to form membranes, heart valves or vessels or are further processed to form solutions, fibers, fiber weaves, fibrous tissues or sponges and are optionally populated with cells and/or used for carrying out controlled tissue regeneration.