Patents Assigned to Matrix Laboratories Limited
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Publication number: 20130231486Abstract: Disclosed herein are novel compounds which are useful as intermediates for producing substituted sulfoxide compounds and a process for producing the same. Further disclosed is a process for producing the substituted sulfoxide compounds used as pharmacologically active agents, employing the novel intermediates of the present invention.Type: ApplicationFiled: April 11, 2013Publication date: September 5, 2013Applicant: Matrix Laboratories LimitedInventors: Saswata LAHIRI, Lakshmana Rao VADALI, Swamy SAIDUGARI, Verra Narayana BANDLAMUDI, Parameshwar MAKAM, Seshadri Rao MANUKONDA, Debashish DATTA
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Patent number: 8513427Abstract: Disclosed herein are novel compounds which are useful as intermediates for producing substituted sulfoxide compounds and a process for producing the same. Further disclosed is a process for producing the substituted sulfoxide compounds used as pharmacologically active agents, employing the novel intermediates of the present invention.Type: GrantFiled: September 29, 2009Date of Patent: August 20, 2013Assignee: Matrix Laboratories LimitedInventors: Saswata Lahiri, Lakshmana Rao Vadali, Swamy Saidugari, Verra Narayana Bandlamudi, Parameshwar Makam, Seshadri Rao Manukonda, Debashish Datta
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Patent number: 8513455Abstract: The present invention relates to a crystalline oxybutynin base and process for preparing the same. Further, this invention discloses a process for preparing an acid addition salt of oxybutynin employing the crystalline oxybutynin base.Type: GrantFiled: February 4, 2009Date of Patent: August 20, 2013Assignee: Matrix Laboratories LimitedInventors: Purna Chandra Ray, Madhuresh Sethi, Sanjay Mahajan, Om Dutt Tyagi
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Patent number: 8350030Abstract: Disclosed herein an improved process for producing 5-Fluoro-1-(2R,5S)-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine and its pharmaceutical acceptable salts.Type: GrantFiled: December 5, 2008Date of Patent: January 8, 2013Assignee: Matrix Laboratories LimitedInventors: Om Dutt Tyagi, Umamaheswar Vasireddy Rao, Vellanki Sivarama Prasad, Arabinda Sahu
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Patent number: 8329952Abstract: The present invention relates to process for the preparation of novel crystalline Desmethylvenlafaxine succinate polymorphic Forms-A, B. The present invention also relates to novel processes for the preparation of 0-Desmethylvenlafaxine succinate polymorphic Forms-(I), (II), (III) and amorphous.Type: GrantFiled: July 15, 2008Date of Patent: December 11, 2012Assignee: Matrix Laboratories LimitedInventors: Ramakoteswara Rao Jetti, Purandhar Koilkonda, Jagan Mohana Chary Tummanapally, Mohana Vamsi Krishna Vadlamudi, Prasanth Kumar Barik, Om Dutt Tyagi
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Patent number: 8318930Abstract: Disclosed herein is a novel process for preparing polymorphic Forms of (S)-6-chloro-(cyclopropylethynyl)-1,4-di-hydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one referred as M1, I, II, ?, and ?.Type: GrantFiled: December 24, 2008Date of Patent: November 27, 2012Assignee: Matrix Laboratories LimitedInventors: Om Dutt Tyagi, Ramakoteswara Rao Jetti, B. A. Ramireddy
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Patent number: 8304578Abstract: The present invention relates to an improved, process for large scale production of 1-[2-(dimethylamino)-1-(4-phenol)ethyl]cyclohexanol (O-desmethylvenlafaxine) or its pharmaceutically acceptable salts with increased yield and minimal impurities.Type: GrantFiled: December 26, 2008Date of Patent: November 6, 2012Assignee: Matrix Laboratories LimitedInventors: Om Dutt Tyagi, Saswata Lahiri, Purandhar Koilkonda, Jagan Mohana Chary Tummanapally, Mohan Vamsi Krishna Vadlamudi, Venkata Bala Kishore Sarma Inupakutika, Surya Nageswara Rao Achanta
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Publication number: 20110184182Abstract: Disclosed herein are novel compounds which are useful as intermediates for producing substituted sulfoxide compounds and a process for producing the same. Further disclosed is a process for producing the substituted sulfoxide compounds used as pharmacologically active agents, employing the novel intermediates of the present invention.Type: ApplicationFiled: September 29, 2009Publication date: July 28, 2011Applicant: MATRIX LABORATORIES LIMITEDInventors: Saswata Lahiri, Lakshmana Rao Vadali, Swamy Saidugari, Verra Narayana Bandlamudi, Parameshwar Makam, Seshadri Rao Manukonda, Debashish Datta
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Publication number: 20110144383Abstract: Disclosed herein is a process for the preparing (S)-3-(aminomethyl)-5-methylhexanoic acid by optical resolution of (±)-3-(aminomethyl)-5-methylhexanoic acid and a resolving agent employing a suitable solvent.Type: ApplicationFiled: February 18, 2009Publication date: June 16, 2011Applicant: MATRIX LABORATORIES LIMITEDInventors: Ataharoddin Khala, Venkata Srinivas Rao Potla, Govind Singh Rawat, Babu Rao Konudula, Yogendra Kumar Chauhan, Debashish Datta
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Patent number: 7943784Abstract: The present invention encompasses a method for the preparation of Almotriptan and its pharmaceutically acceptable salts comprises, i) Methylation of 3-[5-(1-Pyrrolidinyl sulfonyl methyl)1H-indol-yl]ethane amine ii) Treating crude Almotriptan with a hydroxy benzoic acid yields hydroxy benzoic acid addition salt of Almotriptan iii) Converting Almotriptan hydroxy benzoic acid addition salt to Almotriptan and iv) Salification of Almotriptan to its pharmaceutically acceptable salts.Type: GrantFiled: July 21, 2006Date of Patent: May 17, 2011Assignee: Matrix Laboratories LimitedInventors: Satyanarayana Chava, Seeta Ramanjaneyulu Gorantla, Ramdas Chavakula, Babu Rao Konudula
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Publication number: 20110087042Abstract: The present invention relates to a crystalline oxybutynin base and process for preparing the same. Further, this invention discloses a process for preparing an acid addition salt of oxybutynin employing the crystalline oxybutynin base.Type: ApplicationFiled: February 4, 2009Publication date: April 14, 2011Applicant: MATRIX LABORATORIES LIMITEDInventors: Chandra Purna Ray, Madhuresh Sethi, Sanjay Mahajan, Om Dutt Tyagi
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Patent number: 7884214Abstract: The present invention encompasses a method for the preparation of Telmisartan comprises, through Telmisartan dihydrochloride comprises i) Condensing 4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid with N-Methyl-O-phenylenediamine dihydrochloride to yields 4-methyl-6 (1-methyl benzimidazol-2-yl)-2-n-propyl 1H-benzimidazole ii) Treating 4-methyl-6-(1-methylbenzimidazol-2-yl)-2-n-propyl-1H-benzimidazole with 4?-(bromomethyl)-2-biphenyl-2-carboxylate in presence of a base in an organic solvent and isolating the ester as acid addition salt iii) Converting ester acid addition salt to Telmisartan dihydrochloride and iv) Converting Telmisartan dihydrochloride to Telmisartan.Type: GrantFiled: July 19, 2006Date of Patent: February 8, 2011Assignee: Matrix Laboratories LimitedInventors: Satyanarayana Chava, Seeta Ramanjaneyulu Gorantla, Sai Prasanna Bhagya Lakshmi Ginjupalli
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Publication number: 20100286447Abstract: The present invention relates to an improved, process for large scale production of 1-[2-(dimethylamino)-1-(4-phenol)ethyl]cyclohexanol (O-desmethylvenlafaxine) or its pharmaceutically acceptable salts with increased yield and minimal impurities.Type: ApplicationFiled: December 26, 2008Publication date: November 11, 2010Applicant: MATRIX LABORATORIES LIMITEDInventors: Om Dutt Tyagi, Saswata Lahiri, Purandhar Koilkonda, Jagan Mohana Chary Tummanapally, Mohan Vamsi Krishna Vadlamudi, Venkata Bala Kishore Sarma Inupakutika, Surya Nageswara Rao Achanta
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Publication number: 20100274007Abstract: Disclosed herein is a novel process for preparing polymorphic Forms of (S)-6-chloro-(cyclopropylethynyl)-1,4-di-hydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one referred as M1, I, II, ?, and ?.Type: ApplicationFiled: December 24, 2008Publication date: October 28, 2010Applicant: MATRIX LABORATORIES LIMITEDInventors: Om Dutt Tyagi, Ram K. R. Jetti, B. A. Ramireddy
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Publication number: 20100256372Abstract: Disclosed herein an improved process for producing 5-Fluoro-1-(2R,5S)-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine and its pharmaceutical acceptable salts.Type: ApplicationFiled: December 5, 2008Publication date: October 7, 2010Applicant: MATRIX LABORATORIES LIMITEDInventors: Om Dutt Tyagi, Umamaheswar Vasireddy Rao, Vellanki Sivarama Prasad, Arabinda Sahu
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Publication number: 20100191015Abstract: The present invention relates to process for the preparation of novel crystalline Desmethylvenlafaxine succinate polymorphic Forms-A, B. The present invention also relates to novel processes for the preparation of 0-Desmethylvenlafaxine succinate polymorphic Forms-(I), (II), (III) and amorphous.Type: ApplicationFiled: July 15, 2008Publication date: July 29, 2010Applicant: MATRIX LABORATORIES LIMITEDInventors: Ramakoteswara Rao Jetti, Purandhar Koilkonda, Jagan Mohana Chary Tummanapally, Mohana Vamsi, Krishna Vadlamudi, Prasanth Kumar Barik, Om Dutt Tyagi
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Patent number: 7678903Abstract: The present invention relates to an improved process for the preparation of Levofloxacin hemihydrate by adjusting the moisture content of the solvent to about 12% to about 20% during crystallization.Type: GrantFiled: August 8, 2005Date of Patent: March 16, 2010Assignee: Matrix Laboratories LimitedInventors: Satya-naryana Chava, Seeta Ramanjaneyulu Gorantla, Venkata Panakala Rao
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Publication number: 20090259051Abstract: The present invention relates a novel crystalline 1-(Carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy) ethyl]amino]-2-propanol phosphate sesquihydrate (Carvedilol dihydrogenphosphate sesquihydrate), methods of preparing the sesquihydrate by adding phosphoric acid to a suspension of Carvedilol in water, water miscible solvents or a mixture of water and water miscible organic solvent followed by isolating the product directly or by adding solvent.Type: ApplicationFiled: June 11, 2007Publication date: October 15, 2009Applicant: Matrix Laboratories LimitedInventors: Seeta Ramanjaneyulu Gorantla, Mohan Bandari, Nageswara Rao Karusala, Sankara Sastry Tummalapalli
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Publication number: 20080167477Abstract: The present invention provides novel crystalline polymorphic forms and amorphous form of carvedilol dihydrogen phosphate characterized by different solid state techniques. The novel processes for their preparation are also disclosed.Type: ApplicationFiled: September 7, 2007Publication date: July 10, 2008Applicant: MATRIX LABORATORIES LIMITEDInventors: Ramakoteswara Rao JETTI, Asha Rani GORANTLA, Om Dutt TYAGI
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Patent number: 7365216Abstract: The invention relates to a process for the manufacture of salts of citalopram in high purity. By the careful selection of solvents and the careful manipulation of the pH value, citalopram salts may be isolated in the absence of 5-chlorocitalopram, 5-bromocitalo-pram, desmethyl-citalopram and 5-carobxyamide citalopram.Type: GrantFiled: April 18, 2002Date of Patent: April 29, 2008Assignee: Matrix Laboratories LimitedInventors: Jyothi Basu Abbineni, Hari Babu Bodepudi, Satyanarayana Chava, Venkata Ramana Rao Chunchu