Patents Assigned to Matrix Laboratories Ltd.
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Patent number: 8247568Abstract: The present invention relates to a process for the preparation of pure Rabeprazole sulfoxide using the solvent mixture for the extraction steps and this invention further relates to the process for the preparation of amorphous Rabeprazole sodium using pure rabeprazole base in presence of aqueous NaOH and water miscible solvent and adding an anti-solvent.Type: GrantFiled: June 19, 2008Date of Patent: August 21, 2012Assignee: Matrix Laboratories LtdInventors: Om Dutt Tyagi, Purna Chandra Ray, Madhuresh Kumar Sethi, Bhausaheb Chavhan
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Publication number: 20110301357Abstract: The present invention relates to novel and stable polymorphic forms of Perindopril (L)-Arginine designated as Form ? and amorphous form and processes for their preparation. The present invention also provides the novel polymorph Form ? with greater stability to heat and humidity and can be prepared on large scale by an efficient, economic and reproducible process.Type: ApplicationFiled: June 22, 2009Publication date: December 8, 2011Applicant: MATRIX LABORATORIES LTDInventors: Ramakoteswara Rao Jetti, Chetan Kanaiyalal Raval, Aggi Ramireddy Bommareddy, Debashish Datta
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Patent number: 8058453Abstract: A cost-effective, industrially feasible process for the manufacture of crystalline Carvedilol Form-II using novel Carvedilol salts comprises the steps of reacting 4-(2,3-epoxy propoxy)carbazole (II) with 2-(2-methoxy phenoxy)ethyl amine (III) followed by acidification with mineral acid in presence of an organic solvent to yield acid addition salts, treatment of the said salts with base(s) in presence of organic solvent(s), water and isolation from the organic solvent(s) followed by crystallization from ethyl acetate.Type: GrantFiled: December 22, 2008Date of Patent: November 15, 2011Assignee: Matrix Laboratories Ltd.Inventors: Gorantla Seeta Ramanjaneyulu, Indukuri Venkata Sunil Kumar, Ketavarapu Narasimha Rao, Jammula Vera Venkata Krishna Kishore
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Patent number: 8048904Abstract: The present invention provides a process for the preparation of Olmesartan medoxomil by condensing the ethyl 4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylate with 4-[2-(trityl tetrazol-5-yl)phenyl]benzyl bromide to obtain ethyl 4-(1-hydroxy-1-methyl ethyl)-2-propyl-1-{4-[2-(trityl tetrazol-5-yl)phenyl]phenyl}methylimidazole-5-carboxylate and then hydrolyzing ethyl 4-(1-hydroxy-1-methyl ethyl)-2-propyl-1-{4-[2-(trityl tetrazol-5-yl)phenyl]phenyl}methyl imidazole-5-carboxylate to obtain trityl Olmesartan dihydrate followed by reacting trityl Olmesartan dihydrate with 4-chloromethyl-5-methyl-2-oxo-1,3-dioxolene to obtain trityl Olmesartan medoxomil and then deprotecting trityl Olmesartan medoxomil to obtain Olmesartan medoxomil.Type: GrantFiled: June 15, 2007Date of Patent: November 1, 2011Assignee: Matrix Laboratories Ltd.Inventors: Gorantla Seeta Ramanjaneyulu, Bandari Mohan, Purna Chandra Ray, Madhuresh Kumar Sethi, Vijendra Singh Rawat, Yerramalla Raja Krishna, Vemula Lakshminarayana, Mamidi Srinivas
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Patent number: 8049009Abstract: The present invention relates to novel Tenofovir disoproxil hemifumarate salt, which is prepared by dealkylation of Phosphonate esters by using mineral acids followed by esterification and crystallization to give crystalline Tenofovir disoproxil. The Tenofovir disoproxil is further converted to fumarate salts with improved yield.Type: GrantFiled: January 12, 2009Date of Patent: November 1, 2011Assignee: Matrix Laboratories Ltd.Inventors: Uma Maheswer Rao Vasireddy, Siva Rama Prasad Vellanki, Raja Babu Balusu, Naga Durga Rao Bandi, Pavan Kumar Jujjavarapu, Sambasiva Rao Ginjupalli, Rama Krishna Pilli
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Patent number: 8026356Abstract: The present invention provides a method for preparing pure Stavudine having purity more than 99.5% comprises: i) Converting 3?,5?-anhydrothymidine to crude Stavudine, ii) Converting crude Stavudine to stable solvates of Stavudine, iii) Desolvation of the solvates to give pure Stavudine. The present invention also disclosed novel solvates of Stavudine and conversion of novel Stavudine solvates to Stavudine.Type: GrantFiled: November 17, 2006Date of Patent: September 27, 2011Assignee: Matrix Laboratories, Ltd.Inventors: Purna Chandra Ray, Jagan Mohana Chary Tummanapalli, Seeta Ramanjaneyulu Gorantla
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Patent number: 7985759Abstract: The present invention relates to novel compounds representated by formula (I), where R, R1, R2, R3, X, Y, m, n are as defined. The present invention relates to compounds of the general formula I their derivatives, their analogs, their tautomeric forms, their stereoisomers, their diastereomers, their bioisosteres, their polymorphs, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them which are predominantly dipeptidyl peptidase IV inhibitors. The present invention also relates to the processes for the preparation of novel compounds of formula (I) and their use in treating type II diabetes and diabetic complications thereof and also for treating dislipidemia, hypercholesterolemia, obesity and hyperglycemia.Type: GrantFiled: March 30, 2007Date of Patent: July 26, 2011Assignee: Matrix Laboratories Ltd.Inventors: Gopalan Balasubramanian, Ravi Dhamjewar, Rasheed Mohammed, Sreedhara Swamy Keshavapura Hosamane, Ishtiyaque Ahmad
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Patent number: 7943780Abstract: The invention relates to process for the preparation of Candesartan cilexetil. More particularly, it relates to the preparation of pure candesartan cilexetil by the deprotection of Trityl candesartan cilexetil with inorganic acids.Type: GrantFiled: February 14, 2007Date of Patent: May 17, 2011Assignee: Matrix Laboratories Ltd.Inventors: Seeta Ramajaneyulu Gorantla, Mohan Bandari, Nageswara Rao Karusala
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Publication number: 20110065917Abstract: The present invention relates to an improved process for the preparation of 10-oxo-10,11-dihydiO-5H-dibenz[b,fjazepine-5-carboxamide (Oxcarbazepine) by reacting 10-methoxy-5H-dibenz[b,f]azepine (10-methoxyiminostilbene) and alkali metal cyanate in presence of ?-hydroxy acids, and also relates to the process for the preparation of carbamazepine from iminostilbene. Further the present invention is directed to the novel crystalline form of 10-methoxy carbamazepine.Type: ApplicationFiled: May 6, 2009Publication date: March 17, 2011Applicant: MATRIX LABORATORIES LTDInventors: Nageswara Rao Karusala, Uma Sankara Sastry Tummalapally, Appi Reddy Talatala, Debashish Datta
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Patent number: 7781585Abstract: The present invention relates to a process for purification of novel polymorphic form of Gatifloxacin which comprises dissolving Gatifloxacin in about 15-50 volumes of methanol, removing insolubles if any, adding organic base to the solution, maintaining the solution at temperature of 30° C. to 70° C., for about 20 min to 4 hrs, followed by gradual cooling and maintaining the reaction mass to ?10 to 20° C. for about 1-4 hrs, isolation and drying at temperature of about 45° C. to 65° C.Type: GrantFiled: May 25, 2005Date of Patent: August 24, 2010Assignee: Matrix Laboratories LtdInventors: Chava Satyanarayana, Gorantla Seeta Ramanjaneyulu, Indukuri Venkata Sunil Kumar
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Publication number: 20100197932Abstract: An improved process for the preparation of substantially pure valsartan employing suitable reagents such as chelating agent and reaction conditions.Type: ApplicationFiled: June 26, 2008Publication date: August 5, 2010Applicant: MATRIX LABORATORIES LTDInventors: Om Dutt Tyagi, Jakka Devendra Rao, Katukuri Aravind Kumar, Dammalapati Ventaka Lakshmi Narasimha Rao
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Publication number: 20100190989Abstract: The present invention relates to a process for the preparation of pure Rabeprazole sulfoxide using the solvent mixture for the extraction steps and this invention further relates to the process for the preparation of amorphous Rabeprazole sodium using pure rabeprazole base in presence of aqueous NaOH and water miscible solvent and adding an anti-solvent.Type: ApplicationFiled: June 19, 2008Publication date: July 29, 2010Applicant: MATRIX LABORATORIES LTDInventors: Om Dutt Tyagi, Purna Chandra Ray, Madhuresh Kumar Sethi, Bhausaheb Chavhan
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Publication number: 20100168432Abstract: The present invention relates to a process for the preparation of Montelukast or a salt thereof comprises, i) condensing Methyl-2-[3-[3-(2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-chloro propyljbenzoate obtained above with 1-(mercaptomethyl)cyclopropane acetic acid in presence of alkali carbonates such as Cesium Carbonate, followed by salification with organic amine ii) neutralizing the organic amine salt as obtained above with organic/inorganic acid followed by reaction with methylmagnesium chloride in the presence of Cerium Chloride followed by treatment with organic base yields montelukast amine salt iii) converting the montelukast amine salt to Montelukast Free acid iv) saltification of Montelukast free acid with Sodium hydroxide affords Montelukast Sodium.Type: ApplicationFiled: June 30, 2006Publication date: July 1, 2010Applicant: MATRIX LABORATORIES LTDInventors: Chava Satyanarayana, Gorantla Seeta Ramanjaneyulu, Indukuri Venkata Sunil Kumar
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Publication number: 20090253932Abstract: The present invention relates to novel chiral resolving agents and a process for resolution of racemic organic acids and their derivatives of the formula (+, ?)—R1R2CHCOOR3 with Cis-(1S,4S)-4[3,4-dichlorophenyl]-1,2,3,4-tetrahydro-N-methyl-1-naphthaloneamine and its Cis-(1R,4R)-isomer as well as Trans-(1S,4R)-4[3,4-dichlorophenyl]-1,2,3,4-tetrahydro-N-methyl-1-naphthaloneamine and its Trans-(1R,4S)-isomer.Type: ApplicationFiled: July 28, 2005Publication date: October 8, 2009Applicant: Matrix Laboratories LtdInventors: Chava Satyanarayana, Bandari Mohan, Madhuresh Kumar Sethl
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Publication number: 20090143590Abstract: The present invention relates to an improved process for the preparation of 1-[[[(1R)-1-[3[(1E)-2-(7chloro-2-quinolinyl) ethenyl] phenyl]-3-[2-(1-hydroxy-1-methylethyl) phenyl] propyl] thio] methyl] cyclopropaneacetic acid (Formula-1) and its salts using Methyl 2-[(3S)-[3-[(2E)-(7-chloro quinolin-2-yl) ethenyl] phenyl]-3-halopropyl] benzoate (Formula-2)Type: ApplicationFiled: July 19, 2004Publication date: June 4, 2009Applicant: MATRIX LABORATORIES LTD.Inventors: Satyanarayana Chava, Seeta Ramanjaneyulu Gorantla, Venkata Sunil Kumar Indukuri, Srinivas Simhadri, Vera Venkata Krishna Kishore Jammula
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Publication number: 20090062550Abstract: The present invention provides a method for preparing pure Rizatriptan benzoate having purity more than 99.5% and dimer impurity less than 0.1% comprises, i) Condensation of 1,2,4-Triazole with 4-Nitro benzyl bromide to yield 1-(4-nitrophenyl)methyl-1,2,4-triazole ii) Reducing the 1-(4-nitrophenyl)methyl-1,2,4-triazole to give 1-(4-aminophenyl)methyl-1,2,4-triazole iii) Converting 1-(4-aminophenyl)methyl-1,2,4-triazole to 1-(4-hydrazinophenyl)methyl-1,2,4-triazole hydrochloride iv) Condensing the hydrazine derivative with 4-(Dimethylamino) butanal diethylacetal to get Rizatriptan and v) Salification of Rizatriptan to Rizatriptan benzoate.Type: ApplicationFiled: November 14, 2006Publication date: March 5, 2009Applicant: MATRIX LABORATORIES LTDInventors: Purna Chandra Ray, Mohan Bandari, Mohammed Qadeeruddin, Seeta Ramanjaneyulu Gorantla
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Publication number: 20090023932Abstract: The present invention encompasses a method for the preparation of Telmisartan comprises, through Telmisartan dihydrochloride comprises i) Condensing 4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid with N-Methyl-O-phenylenediamine dihydrochloride to yields 4-methyl-6 (1-methyl benzimidazol-2-yl)-2-n-propyl 1H-benzimidazole ii) Treating 4-methyl-6-(1-methylbenzimidazol-2-yl)-2-n-propyl-1H-benzimidazole with 4?-(bromomethyl)-2-biphenyl-2-carboxylate in presence of a base in an organic solvent and isolating the ester as acid addition salt iii) Converting ester acid addition salt to Telmisartan dihydrochloride and iv) Converting Telmisartan dihydrochloride to Telmisartan.Type: ApplicationFiled: July 19, 2006Publication date: January 22, 2009Applicant: MATRIX LABORATORIES LTDInventors: Satyanarayana Chava, Seeta Ramanjaneyulu Gorantla, Sai Prasanna Ginjupalli
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Patent number: 7468442Abstract: The present invention provides a cost-effective, industrially feasible process for the manufacture of crystalline Carvedilol Form-II using novel Carvedilol salts comprising a step of reacting 4-(2,3-epoxy propoxy)carbazole (II) with 2-(2-methoxy phenoxy)ethyl amine (III) followed by acidification with mineral acid in presence of an organic solvent to yield acid addition salts, treatment of the said salts with base(s) in presence of organic solvent(s), water and isolation from the organic solvent(s) followed by crystallization from ethyl acetate.Type: GrantFiled: April 16, 2004Date of Patent: December 23, 2008Assignee: Matrix Laboratories Ltd.Inventors: Gorantla Seeta Ramanjaneyulu, Indukuri Venkata Sunil Kumar, Ketavarapu Narasimha Rao, Jammula Vera Venkata Krishna Kishore
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Publication number: 20080312428Abstract: The present invention provides a method for preparing pure Stavudine having purity more than 99.5% comprises: i) Converting 3?,5?-anhydrothymidine to crude Stavudine, ii) Converting crude Stavudine to stable solvates of Stavudine, iii) Desolvation of the solvates to give pure Stavudine. The present invention also disclosed novel solvates of Stavudine and conversion of novel Stavudine solvates to Stavudine.Type: ApplicationFiled: November 17, 2006Publication date: December 18, 2008Applicant: MATRIX LABORATORIES LTDInventors: Purna Chandra Ray, Jagan Mohana Chary Tummanapalli, Seeta Ramanjaneyulu Gorantla
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Patent number: 7439387Abstract: The present invention relates to a new industrial feasible process for the preparation of Gabapentin Form-II via a novel intermediate Gabapentin hemisulphate hemihydrate with out forming Gabapentin Form-III by neutralizing the Gabapentin hemisulphate hemihydrate solution with a base at higher temperatures followed by cooling to yield Gabapentin Form II with sulphate ions less than 100 ppm with respect to Gabapentin.Type: GrantFiled: April 16, 2004Date of Patent: October 21, 2008Assignee: Matrix Laboratories Ltd.Inventors: Chava Satyanarayana, Gorantla Seeta Ramanjaneyulu, Indukuri Venkata Sunil Kumar