Abstract: Antiproliferative compositions are provided which are capable of sustained release of an antiproliferative agent, particularly a TGF-.beta., at a site proximal to a target cell. The compositions are effective in inhibiting proliferation of the target cell, particularly when used in combination with a vasoconstrictive agent.
Type:
Grant
Filed:
April 28, 1994
Date of Patent:
January 28, 1997
Assignees:
Oncogen, Matrix Pharmaceuticals
Inventors:
Dennis M. Brown, Edward Luck, Daniel R. Twardzik, Anthony F. Purchio