Abstract: A tube capper and decapper and method of using the same. The tube capper includes a handheld housing that supports a one-dimensional array of spindles. Each spindle is shaped to receive a cap. A drive mechanism rotates each spindle of the one-dimensional array in unison for capping or decapping a corresponding one-dimensional array of tubes.

Abstract: A liquid handling system that is configured to receive an interchangeable pipetting head that is selected from a plurality of interchangeable pipetting heads for automated liquid handling flexibility and scalability. The system includes a housing and at least one pipetting head disposed within that housing for aspirating and dispensing a liquid. A locking mechanism interchangeably receives the at least one pipetting head and includes an adaptor plate and a support block. The adaptor plate is operably coupled to the housing and the support block is operably coupled to the at least one pipetting head. The support block is then, in turn, is configured to be operably coupled to the adaptor plate.

Abstract: An air displacement pipette has a tubular pipette tip with an upper section surrounding a locking chamber, and a body section leading from the upper section and tapering downwardly to a reduced diameter end. A tubular mounting shaft on the pipette has a distal end configured and dimensioned for axial insertion into the locking chamber of the pipette tip. Coacting surfaces on the distal end of the mounting shaft and the upper section of the pipette tip establish an axially interengaged relationship between the pipette tip and the mounting shaft in response to insertion of the distal end of the mounting shaft into the locking chamber. A sleeve is axially shiftable on the mounting shaft between a retracted position accommodating the establishment of the axially interengaged relationship, and an advanced position disrupting the axially interengaged relationship to thereby accommodate axial ejection of the pipette tip from the mounting shaft.

Abstract: The invention provides hand-held pipettor in accordance with an embodiment that includes a piston that is received in one end of a cylinder, a pipettor tip that is removably secured to an opposite end of said cylinder, a manually driven unit that reciprocates the piston through a selected stroke to aspirate fluid into and to expel the thus aspirated fluid from the pipettor tip, a mechanism including a stepper motor responsive to control signals for adjusting a range of the stroke, and a voice recognition system that decodes verbal commands and outputs the result to a central processing unit, which in turn generates the control signals.

Abstract: A tube capper and decapper and method of using the same. The tube capper includes a handheld housing that supports a one-dimensional array of spindles. Each spindle is shaped to receive a cap. A drive mechanism rotates each spindle of the one-dimensional array in unison for capping or decapping a corresponding one-dimensional array of tubes.

Abstract: An air displacement pipette has a tubular pipette tip with an upper section surrounding a locking chamber, and a body section leading from the upper section and tapering downwardly to a reduced diameter end. A tubular mounting shaft on the pipette has a distal end configured and dimensioned for axial insertion into the locking chamber of the pipette tip. Coacting surfaces on the distal end of the mounting shaft and the upper section of the pipette tip establish an axially interengaged relationship between the pipette tip and the mounting shaft in response to insertion of the distal end of the mounting shaft into the locking chamber. A sleeve is axially shiftable on the mounting shaft between a retracted position accommodating the establishment of the axially interengaged relationship, and an advanced position disrupting the axially interengaged relationship to thereby accommodate axial ejection of the pipette tip from the mounting shaft.

Abstract: An air displacement pipette has a tubular pipette tip with an upper section surrounding a locking chamber, and a body section leading from the upper section and tapering downwardly to a reduced diameter end. A tubular mounting shaft on the pipette has a distal end configured and dimensioned for axial insertion into the locking chamber of the pipette tip. Coacting surfaces on the distal end of the mounting shaft and the upper section of the pipette tip establish an axially interengaged relationship between the pipette tip and the mounting shaft in response to insertion of the distal end of the mounting shaft into the locking chamber. A sleeve is axially shiftable on the mounting shaft between a retracted position accommodating the establishment of the axially interengaged relationship, and an advanced position disrupting the axially interengaged relationship to thereby accommodate axial ejection of the pipette tip from the mounting shaft.

Abstract: A pipettor includes a frame, a syringe carriage coupled to the frame and carrying at least one syringe therein, and an actuator assembly coupled to the frame and to the syringe having a first contact surface coupled to a first drive mechanism and a second contact surface coupled to a second drive mechanism, wherein the first and second contact surfaces cooperate to provide non-contact dispensing of a liquid sample from the syringe. A method of dispensing a liquid sample includes moving a first contact surface disposed beneath a head of a syringe to define a first gap therebetween, moving a second contact surface above the head into contact with the head, and using the second contact surface to drive the head into forceful contact with the first contact surface to dispense the liquid sample from the syringe in a non-contact operation.

Abstract: A method of sealing the open mouths of an array of test tubes comprises providing a plurality of plugs with upwardly facing recesses, and a flexible carrier sheet having the same array of mutually spaced downwardly projecting pegs inserted into and frictionally retained within the recesses of respective ones of the plugs. Sealing is effected by aligning the plugs with the open mouths of the test tubes, pressing the carrier sheet towards the test tubes to seat the plugs in the open tube mouths, and peeling the carrier sheet away from the test tubes to extract the pegs from the plug recesses while allowing the plugs to remain seated in the tube mouths.

Abstract: A hand-held pipette includes a piston driven by an actuator assembly contained within a housing having first and second mutually spaced non-adjustable stops. The actuator assembly is subdivided into first and second sections respectively provided with first and second contact surfaces. The actuator assembly is arranged to reciprocate between a rest position at which the first contact surface is in contact with the first stop and the second contact surface is spaced from the second stop by a control distance, and an advanced position at which the second contact surface is in contact with the second stop and the first contact surface is spaced from the first stop, with the stroke of the actuator assembly and the stroke of the piston being equal to the control distance. A motor-driven mechanism is arranged to displace one section of the actuator assembly relative to the other section, resulting in a corresponding change to both the overall length of the actuator assembly and the control distance.

Abstract: A hand-held pipettor comprising a piston received in one end of a cylinder, a pipettor tip removably secured to an opposite end of said cylinder, means for reciprocating said piston through a selected stroke to aspirate fluid into and to expel the thus aspirated fluid from said pipettor tip, mutually spaced stop members operatively associated with said manually driven means for defining the range of said stroke and motor driven means for varying the spacing between said stop members to thereby vary the volume of fluid being aspirated into and expelled from said pipettor tip.

Abstract: A tube rack comprises a base having an array of vertical openings extending therebetween, the openings being configured and dimensioned to receive a plurality of tubes, with the upper ends of the tubes being accessible at the top surface. The base includes base sidewalls that each include a co-axial trunnion extending from the associated sidewall.

Abstract: Disclosed is a polymerizable complex containing a covalently attached nucleic acid molecule which, under appropriate conditions, is capable of copolymerization with a second polymerizable ethylene-containing monomer unit to form a polymerized layer. The polymerized layer containing attached nucleic acid is useful in a variety of contexts including, for example, hybridization assays. The polymerized layer containing the covalently attached nucleic acid molecule can be formed into a variety of shapes, or attached to a formed material through appropriate chemistry.

Abstract: A method of uniquely identifying a plurality of discrete test tubes. The method includes providing a rack having an array of wells located at the intersections of mutually perpendicular columns and rows. The rack is marked to orient the rack from top to bottom and left to right. Each well is identifiable by reference to a sequence of letters and numbers identifying its respective intersecting column and row. A plurality of test tubes are positioned in the wells. The test tubes have open tops and closed lower ends protruding through the open bottoms of the wells. Indicia are applied to the respective closed lower ends of the test tubes positioned in the wells. The application of the indicia is performed in situ and simultaneously as a single step to all of the test tubes in the wells, thereby resulting in each test tube being uniquely identified with reference to its respective well.

Abstract: A method is provided for immobilizing a ligand, e.g., a nucleic acid, on a solid support. The method includes providing a solid support containing an immobilized latent thiol group, activating the thiol group, contacting the activated thiol group with a nucleic acid comprising an acrylamide functional group, and forming a covalent bond between the two groups, thereby immobilizing the nucleic acid to the solid support. Kits containing the solid supports and method of utilizing the solid supports are also provided.

Abstract: A method is provided for immobilizing a ligand, e.g., a nucleic acid, on a solid support. The method includes providing a solid support containing an immobilized latent thiol group, activating the thiol group, contacting the activated thiol group with a nucleic acid comprising an acrylamide functional group, and forming a covalent bond between the two groups, thereby immobilizing the nucleic acid to the solid support. Kits containing the solid supports and method of utilizing the solid supports are also provided.

Abstract: A method is provided for immobilizing a ligand, e.g., a nucleic acid, on a solid support. The method includes providing a solid support containing an immobilized latent thiol group, activating the thiol group, contacting the activated thiol group with a nucleic acid comprising an acrylamide functional group, and forming a covalent bond between the two groups, thereby immobilizing the nucleic acid to the solid support. Kits containing the solid supports and method of utilizing the solid supports are also provided.

Abstract: A test tube comprises a tube body of unitary construction including an enclosed sidewall and an integral bottom surface that together define a tubular container having an open top. The bottom surface has a concave interior surface and a planar exterior surface upon which machine readable data is encoded within a multi-layered opaque coating that is deposited onto the planar exterior surface to uniquely identify the test tube. The machine readable data is preferably an open (i.e., non-proprietary) data matrix code. This code is applied to the test tube by depositing a multi-layer coating onto the planar exterior of the tube bottom surface. The multi-layer coating may include a first layer of opaque material that is deposited onto the planar exterior surface, and a second layer of opaque material that is deposited onto the first layer. The machine readable code is formed in the multi-layered coating by removing portions of the second layer.

Abstract: A pipette tip magazine used in an automated pipetting system which has a pipetting chamber with a generally U-shaped ledge. The pipette tip magazine is adapted for insertion into and removal from an operative position contained in the chamber and supported on the ledge. The magazine includes a generally rectangular plate having an undercut edge bordering an inner region. The edge is configured to be supported on the ledge, an the inner region has an array of through openings for vertically receiving and retaining pipette tips. The plate is molded from a polymeric resin reinforced with a fibrous material.

Abstract: A test tube comprises a tube body of unitary construction including an enclosed sidewall and an integral bottom that together define a tubular container having an open top. The bottom has a concave interior surface and a planar exterior surface upon which machine readable data is encoded within a multi-layered opaque coating that is deposited onto the planar exterior surface to uniquely identify the test tube. The machine readable data is preferably an open (i.e., non-proprietary) data matrix code. This code is applied to the test tube by depositing a multi-layer coating onto the planar exterior of the tube bottom. The multi-layer coating may include a first layer of opaque material that is deposited onto the planar exterior surface, and a second layer of opaque material that is deposited onto the first layer. The machine readable code is formed in the multi-layered coating by removing portions of the second layer.