Patents Assigned to MatTek Corporation
  • Publication number: 20180100142
    Abstract: Methods are provided for production of differentiated tissue equivalent model systems from cryopreserved undifferentiated cells. The methods include seeding undifferentiated cells directly onto a support for differentiation immediately after recovery from cryopreservation, without intervening steps for expansion, harvesting, counting, or dilution of the cells.
    Type: Application
    Filed: October 6, 2016
    Publication date: April 12, 2018
    Applicant: MatTek Corporation
    Inventors: Patrick J. Hayden, Michael Bachelor, Mitchell Klausner
  • Publication number: 20080003677
    Abstract: Disclosed is a cervico-vaginal tissue equivalent comprised of vaginal epithelial cells and immune cells, cultured at the air-liquid interface. The tissue equivalent is capable of being infected with a sexually transmitted pathogen such as a virus (e.g., HIV), a bacteria, a helminthic parasite, or a fungus. The tissue equivalent is also capable of undergoing an allergic-type reaction or an irritant-type reaction. The tissue equivalent is characterized as having nucleated basal layer cells and nucleated suprabasal layer cells, and further as having cell layers external to the suprabasal layer progressively increasing in glycogen content and progressively decreasing in nuclei content. Immune cells of the tissue equivalent are primarily located in the basal and suprabasal layers. Also disclosed are methods for producing the tissue equivalent.
    Type: Application
    Filed: June 24, 2005
    Publication date: January 3, 2008
    Applicant: MatTek Corporation
    Inventors: Mitchell Klausner, Seyoum Ayehunie, Joseph Kubilus
  • Patent number: 6943021
    Abstract: Disclosed is a cervico-vaginal tissue equivalent comprised of vaginal epithelial cells and immune cells, cultured at the air-liquid interface. The tissue equivalent is capable of being infected with a sexually transmitted pathogen such as a virus (e.g., HIV), a bacteria, a helminthic parasite, or a fungus. The tissue equivalent is also capable of undergoing an allergic-type reaction or an irritant-type reaction. The tissue equivalent is characterized as having nucleated basal layer cells and nucleated suprabasal layer cells, and further as having cell layers external to the suprabasal layer progressively increasing in glycogen content and progressively decreasing in nuclei content. Immune cells of the tissue equivalent are primarily located in the basal and suprabasal layers. Also disclosed are methods for producing the tissue equivalent.
    Type: Grant
    Filed: June 7, 2002
    Date of Patent: September 13, 2005
    Assignee: MatTek Corporation
    Inventors: Mitchell Klausner, Seyoum Ayehunie, Joseph Kubilus
  • Publication number: 20030228686
    Abstract: Disclosed is a cervico-vaginal tissue equivalent comprised of vaginal epithelial cells and immune cells, cultured at the air-liquid interface. The tissue equivalent is capable of being infected with a sexually transmitted pathogen such as a virus (e.g., HIV), a bacteria, a helminthic parasite, or a fungus. The tissue equivalent is also capable of undergoing an allergic-type reaction or an irritant-type reaction. The tissue equivalent is characterized as having nucleated basal layer cells and nucleated suprabasal layer cells, and further as having cell layers external to the suprabasal layer progressively increasing in glycogen content and progressively decreasing in nuclei content. Immune cells of the tissue equivalent are primarily located in the basal and suprabasal layers. Also disclosed are methods for producing the tissue equivalent.
    Type: Application
    Filed: June 7, 2002
    Publication date: December 11, 2003
    Applicant: MatTek Corporation
    Inventors: Mitchell Klausner, Seyoum Ayehunie, Joseph Kubilus