Abstract: The invention pertains to a RNA molecule transcribed form a long terminal repeat (LTR) sequence, comprising a sequence encoding a gene, such as CSF1R, and a sequence that is at least in part found in the LTR, in particular for detecting cancer in a subject.
Type:
Grant
Filed:
June 21, 2010
Date of Patent:
August 25, 2015
Assignee:
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN BERLIN-BUCH
Inventors:
Stephan Mathas, Björn Lamprecht, Bernd Dörken, Constanze Bonifer
Abstract: The invention refers to polynucleotides selected from the group consisting of a) polynucleotides encoding for the polypeptide RBM20 comprising a P638L mutation for a human polypeptide RBM20, or a P641L mutation for a rat polypeptide RBM20, b) polynucleotides with a reverse complementary sequence of the polynucleotide of a) above, and c) polynucleotides with an identity at least 50% to a polynucleotide of a) or b) above.
Type:
Grant
Filed:
June 22, 2010
Date of Patent:
May 26, 2015
Assignee:
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN BERLIN-BUCH
Inventors:
Michael Gotthardt, Norbert Hübner, Marion Lewis Greaser, Wei Guo