Patents Assigned to MAX-DELBRUCK-CENTRUM FUR MOLEKULAR MEDIZIN
  • Use of aptamers in therapy and/or diagnosis of autoimmune diseases
    Patent number: 9862953
    Abstract: The present invention is directed to an aptamer comprising or consisting of the nucleic acid sequence of SEQ ID No. 1, SEQ ID No. 2, SEQ ID No. 3 and/or a nucleic acid sequence being at least 80% identical to one of SEQ ID No. 1, 2 and 3 for use in therapy and/or diagnosis of autoimmune diseases, wherein the autoimmune disease is cardiomyopathy, dilated cardiomyopathy (DCM), peripartum cardiomyopathy (PPCM), idiopathic cardiomyopathy, Chagas' cardiomyopathy, Chagas' megacolon, Chagas' megaesophagus, Chagas' neuropathy, benign prostatic hyperplasia, scleroderma, psoriasis, Raynaud syndrome, pre-eclamsia, kidney allograft rejection, myocarditis, glaucoma, hypertension, pulmonary hypertension, malignant hypertension, and/or Alzheimer's disease.
    Type: Grant
    Filed: December 22, 2015
    Date of Patent: January 9, 2018
    Assignees: CHARITE—UNIVERSTATSMEDIZIN BERLIN, MAX-DELBRUCK-CENTRUM FUR MOLEKULAR MEDIZIN
    Inventors: Ingolf Schimke, Annekathrin Haberland, Gerd Wallukat
  • Vector for the expression of therapy-relevant genes
    Patent number: 5968735
    Abstract: A vector for expression of relevant therapeutic genes in mammalian cells which utilizes the mdr promoter, and optionally, the mdr enhancer, operably linked to the therapeutic gene.
    Type: Grant
    Filed: May 12, 1995
    Date of Patent: October 19, 1999
    Assignee: Max Delbruck-Centrum fur Molekular Medizin Berlin
    Inventors: Ulrike Stein, Wolfgang Walther