Abstract: The invention provides novel coumarin derivatives as specific mitochondrial RNA polymerase inhibitors for the treatment of cancer.

Abstract: In a first aspect, the present invention relates to a method of determining assembly, homogeneity and/or thermodynamic stability of biological macromolecular complexes. In particular, the method allows determining maximum stability of said complexes based on fluorescence changes at an appropriate wavelength as a function of temperature whereby said fluorescence changes reflect the status of assembly, homogeneity and/or thermodynamic stability of the biological macromolecular complexes. Said method is based on identifying two state and multistate unfolding fluorescence curves as a function of temperature by fitting said curves according to a multistate unfolding model. In addition, a computer program and a computer program storage medium as well as an apparatus and a system is provided for determining the assembly, homogeneity and/or thermodynamic stability of biological macromolecular complexes.

Abstract: A rotary transmission device for a plurality of cables between to coaxial, utually restrictedly rotatable structures, especially for space satellites. One of said structures is formed with a cylindrical housing (9) while the other structure is formed with a hollow hub (8) coaxially extending through said housing (9). At least one support band (3) extends in the form of a spiral between the wall (10) of the housing (9) and the hollow hub (8) and is slidably supported at two plates (1, 2) forming the bottom and the cover of said housing (9). A plurality of individual electrical cables (6) are laid along the support band (3) in a slightly wavelike course, the cables (6) being fixed to the support band (3) at every second wave apex are retained at the other wave apices with radical and axial clearances with respect to the spiral.