Patents Assigned to Max-Planck-Gesellschaft zur Forderung
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Publication number: 20250041609Abstract: An apparatus for determining an arrhythmia of a living heart comprises a signal evaluation device receiving a signal representing a present electric activity of the heart, and determining a frequency spectrum of the signal. The apparatus further comprises a pulse generator generating a sequence of electric pulses to be applied to the heart at a pulse repetition frequency that depends on the frequency spectrum and decreases by at least 20% over the sequence.Type: ApplicationFiled: October 25, 2024Publication date: February 6, 2025Applicant: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.Inventors: Stefan Luther, Ulrich Parlitz, Thomas Lilienkamp
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Publication number: 20250035536Abstract: In order to map the surface of a macromolecule, at least one fluorescent probe is introduced into a medium in which the macromolecule is embedded or will be embedded. Then, a plurality of spatial positions of the at least one fluorescent probe with regard to the macromolecule are determined via localization of the at least one singularized fluorescent probe with a simple standard deviation of no more than 2 nm. For this purpose, fluorescence light photons emitted by the singularized fluorescent probe are recorded. In addition, a bounding surface bounding the determined spatial positions with regard to the macromolecule is determined; and a three-dimensional map of at least a part of the surface of the macromolecule is generated from the bounding surface.Type: ApplicationFiled: October 11, 2024Publication date: January 30, 2025Applicant: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.Inventor: Stefan W. Hell
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Publication number: 20250040443Abstract: According to a method of manufacturing a magnetic memory device, various types of magnetic memory devices can be manufactured at low cost by manufacturing a plurality of magnetic modules by using a delamination phenomenon of pattern segments and stacking the plurality of magnetic modules to complete a stacked memory device.Type: ApplicationFiled: July 18, 2024Publication date: January 30, 2025Applicants: Samsung Electronics Co., Ltd., Max-Planck-Gesellschaft zur Forderung der Wissenschaften e.V.Inventors: Unghwan Pi, Stuart Papworth Parkin, Jaechun Jeon, Jaekeun Kim, Andrea Migliorini
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Patent number: 12209260Abstract: The present invention relates to a fusion protein, comprising the structure N-PCSY-degSigN-M-PCSX-degSigC-C; wherein N represents the N-terminus; PCSY and PCSX each represent a protease cleavage site (PCS), which differ from each other in at least one amino acid residue: degSigN represents a degradation signal which promotes degradation of the fusion protein in a host cell if PCSY is cleaved by a protease such that the first amino acid of degSigN becomes the new N-terminus of the remaining fusion; M represents a cytoplasmic selection marker; and degSigC represents a second degradation signal which promotes degradation of the fusion protein in a host cell if PCSX is not cleaved by a protease; and C represents the C-terminus.Type: GrantFiled: June 13, 2019Date of Patent: January 28, 2025Assignee: MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN E.V.Inventors: Arturo Vera Rodriguez, Dirk Görlich, Steffen Frey
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Publication number: 20250029644Abstract: A magnetic memory device includes a lower magnetic track layer extending in a first direction and including a plurality of first magnetic domains, a spacer layer on the lower magnetic track layer and extending in the first direction, an upper magnetic track layer on the spacer layer and extending in the first direction, the upper magnetic track layer including a plurality of second magnetic domains, and a plurality of read units on the upper magnetic track layer and arranged apart from one another in the first direction, wherein the plurality of first magnetic domains and the plurality of second magnetic domains have magnetization directions parallel to each other at positions overlapping each other in a second direction perpendicular to the first direction.Type: ApplicationFiled: July 16, 2024Publication date: January 23, 2025Applicant: Max-Planck-Gesellschaft zur Forderung der Wissenschaften e.V.Inventors: Unghwan Pi, Stuart Papworth Parkin, Jaechun Jeon, Jaekeun Kim, Andrea Migliorini
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Publication number: 20250029670Abstract: A method of operating a magnetic memory device includes: (i) applying a first current to a free layer of a magnetic tunnel junction structure, which includes a magnetic translation unit (MTU) extending between a first magnetic pad and a second magnetic pad, and a tunnel barrier layer and a pinned layer stacked on the MTU, so that a multi-domain is established within the MTU, (ii) applying a magnetic field to the free layer so that the magnetization direction of the MTU switches to become anti-parallel to the magnetization directions of the first magnetic pad and the second magnetic pad, (iii) applying a second current to the free layer so that a portion of the multi-domain penetrates into the first magnetic pad, and (iv) applying another magnetic field to the free layer so that the magnetization direction of the first magnetic pad switches.Type: ApplicationFiled: July 16, 2024Publication date: January 23, 2025Applicants: Samsung Electronics Co., Ltd., Max-Planck-Gesellschaft zur Forderung der Wissenschaften e.V.Inventors: Unghwan Pi, Stuart Papworth Parkin, Andrea Migliorini, Jaechun Jeon
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Patent number: 12205967Abstract: An avalanche photodiode array for detecting electromagnetic radiation comprises: a semiconductor substrate (100) having a first main surface (101) and a second main surface (102), which are opposite one another, a plurality of n-doped anode regions (1) formed at the first main surface (101) and separated from one another by pixel isolation regions (7), a p-doped cathode region (3) arranged at the second main surface (102) opposite the anode regions, a drift region (4) between the plurality of anode regions (1) and the cathode region (3), and a p-doped multiplication layer (2) arranged below the plurality of anode regions (1) and below the pixel isolation regions (7), and is characterized by an n-doped field reduction layer (9) arranged below the plurality of anode regions (1) and the pixel isolation regions (7) and above the multiplication layer (2).Type: GrantFiled: March 30, 2020Date of Patent: January 21, 2025Assignee: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.Inventors: Rainer Richter, Florian Schopper, Jelena Ninkovic, Alexander Bähr
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Patent number: 12205042Abstract: In one aspect the application relates to a computing system for providing data for modelling a human brain comprises a database including a plurality of datasets (or allow access to a plurality of datasets), each dataset including at least a dynamical model of the brain including at least one node and a neurodataset of a neuroimaging modality input. The at least one node include a representation of a local dynamic model and a parameter set of the local dynamic model.Type: GrantFiled: January 23, 2023Date of Patent: January 21, 2025Assignees: Max-Planck-Gesellschaft Zur Förderung Der Wissenschaften e.V., Baycrest Centre for Geriatric Care, Universite D'Aix Marseille, Centre National De La Recherche Scientifique, Institut National De La Sante Et De La Recherche Medicale, Codebox Computerdienste GmbHInventors: Anthony Randal McIntosh, Jochen Mersmann, Viktor Jirsa, Petra Ritter
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Publication number: 20250019422Abstract: The present invention pertains in the fields of antibody technology, protein engineering, medicine, pharmacology, infection biology, virology, and medical diagnostics. More specifically, the present disclosure provides VHH antibodies that prevent cell entry of and infection by SARS-CoV-2 and that have been selected for potent cross-reaction and cross-neutralization between the original Wuhan strain and the Alpha, Beta, Gamma, Delta, and Mu variants of concern.Type: ApplicationFiled: November 22, 2022Publication date: January 16, 2025Applicant: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.Inventors: Dirk GÖRLICH, Metin AKSU, Oleh RYMARENKO, Thomas GÜTTLER, Renate REES, Kathrin GREGOR, Waltraud TAXER, Jürgen SCHÜNEMANN, Matthias DOBBELSTEIN, Kim Maren STEGMANN, Antje DICKMANNS
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Patent number: 12184030Abstract: A broadband light source device for creating broadband light pulses includes a hollow-core fiber and a pump laser source device. The hollow-core fiber is configured to create the broadband light pulses by an optical non-linear broadening of pump laser pulses. The hollow-core fiber includes a filling gas, an axial hollow light guiding fiber core configured to support core modes of a guided light field, and an inner fiber structure surrounding the fiber core and configured to support transverse wall modes of the guided light field. The pump laser source device is configured to create and provide the pump laser pulses at an input side of the hollow-core fiber. The transverse wall modes include a fundamental transverse wall mode and second and higher order transverse wall modes.Type: GrantFiled: April 12, 2023Date of Patent: December 31, 2024Assignee: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E. V.Inventors: Patrick Sebastian Uebel, Philip St. J. Russell, Sebastian Thomas Bauerschmidt
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Patent number: 12173042Abstract: The current disclosure relates to methods for treating ovarian cancer based on specific antigen expression of the cancer. Furthermore, the expressed antigen may be used in immunotherapeutic methods for treatment of the ovarian cancer. Aspects of the disclosure relate to immunotherapies targeting CT45 polypeptides, methods for treating ovarian cancer based on CT45 expression, and kits for detecting CT45 polypeptides and nucleotides.Type: GrantFiled: January 28, 2022Date of Patent: December 24, 2024Assignees: Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E. V.Inventors: Ernst Lengyel, Matthias Mann, Marion Curtis, Fabian Coscia
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Patent number: 12173309Abstract: The present invention relates to compounds, compositions and kits suitable to precise genome editing efficiency in a eukaryotic target cell or target organism.Type: GrantFiled: April 10, 2018Date of Patent: December 24, 2024Assignee: Max-Planck-Gesellschaft zur Forderung der Wissenschaften e.V.Inventors: Stephan Riesenberg, Tomislav Maricic
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Patent number: 12165683Abstract: A magnetic memory device includes a conductive line that extends in a first direction, and a magnetic track line that extends in the first direction on a top surface of the conductive line. The conductive line may include a first region having a first width in a second direction, and a second region having a second width in the second direction. The first direction and the second direction are parallel to the top surface of the conductive line and are perpendicular to each other. The second width may be greater than the first width. The magnetic track line includes first domains arranged in the first direction on the first region of the conductive line, and second domains arranged in the first direction on the second region of the conductive line. A size of each of the second domains may be less than a size of each of the first domains.Type: GrantFiled: January 12, 2023Date of Patent: December 10, 2024Assignees: Samsung Electronics Co., Ltd., Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.Inventors: Stuart Papworth Parkin, Jaechun Jeon, Andrea Migliorini, Ung Hwan Pi
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Publication number: 20240407177Abstract: The present invention relates to racetrack memory array devices, and more specifically, to a manufacturing method of racetrack memory arrays with integrated magnetic tunnel junction for read/write.Type: ApplicationFiled: September 14, 2022Publication date: December 5, 2024Applicant: MAX PLANCK GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN EVInventors: Stuart S.P. PARKIN, See-Hun YANG, Ungh-wan PI, Jaewoo JEONG
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Publication number: 20240381847Abstract: The present disclosure relates to an electronic tag for behavioural monitoring of animals, the electronic tag comprising a microprocessor and at least one sensor. The electronic tag is configured to obtain, via the at least one sensor, movement data of an animal to which the electronic tag is attached and to determine, based on the obtained movement data, a behaviour of the animal. The disclosure further encompasses a corresponding method as well as an ear tag.Type: ApplicationFiled: May 16, 2024Publication date: November 21, 2024Applicants: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V., SOUTH AFRICAN NATIONAL PARKS, GEPE GEIMUPLAST GMBHInventors: Georg HEINE, Bernd VORNEWEG, Martin Christoph WIKELSKI, Ursula Rosa MÜLLER, Jens KOBLITZ, Ockert Louis VAN SCHALKWYK, Pauli VILJOEN, Johann SCHÖPF, Josef HUTSTEINER, Timm WILD
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Inorganic-organic hybrid compounds including organic platinum-containing anions, for use in medicine
Patent number: 12145951Abstract: The present invention relates to inorganic-organic hybrid compounds for use in medicine or for use as medication, consisting of an inorganic metal cation and an organic platinum-containing cytostatic anion, in particular also a cisplatin derivative.Type: GrantFiled: July 26, 2019Date of Patent: November 19, 2024Assignees: Karlsruher Institut fur Technologie, Max-Planck-Gesellschaft zur Forderung der Wissenschaften e.V.Inventors: Beatrice Lilli Neumeier, Claus Feldmann, Joanna Napp, Frauke Alves -
Patent number: 12145386Abstract: A method for preparing a laser marking system to create a colored laser mark on a specimen by providing a laser marking system and a specimen comprising a surface layer, where the laser marking system has a preset number of laser parameters, and performing an exploration of a first gamut specified by the laser marking system and the specimen. The method further generally comprises creating a design space with a preset number of design points; performing a marking of a sample on the specimen for each design point; measuring the sample using at least one detection device and determining a performance point for each design point; evaluating the performance space with regard to preset performance criteria using an evaluation device; generating an offspring design space with offspring design points; and creating a first gamut using a subset of performance points.Type: GrantFiled: June 21, 2021Date of Patent: November 19, 2024Assignees: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V, Università della Svizzera italiana (USI)Inventors: Hans-Peter Seidel, Vahid Babaei, Sebastian Cucerca, Piotr Didyk
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Publication number: 20240366800Abstract: The present invention relates to improved methods for obtaining purified contrast agents that are suitable for magnetic resonance imaging. The contrast agents are prepared by a method such dynamic nuclear polarization (DNP), hydrogenative parahydrogen induced polarization (PHIP), or Signal Amplification By Reversible Exchange (SABRE). High degrees of purity are achieved by performing an evaporation step to separate a signal enhanced precursor or the contrast agent from a metal catalyst or a source of radicals.Type: ApplicationFiled: August 26, 2022Publication date: November 7, 2024Applicant: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E. V.Inventors: Stefan GLÖGGLER, Sergey KORCHAK
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Publication number: 20240371424Abstract: A method for switching magnetic moments in a magnetic material by: a) heating a system formed from a layer of magnetic material and a layer of a metal contacting and forming an interface with one surface of the magnetic material layer, the heating step increasing the temperature to at least 1 to 100 K above the blocking temperature of the magnetic material, b) applying current pulses having a fall time to the system at least at a point in time when the system is heated to at least 1 to 100 K above the blocking temperature of the magnetic material, thereby generating a spin texture in the magnetic material layer and c) then cooling the system to a temperature of below the blocking temperature at a cooling rate which is greater than the current pulses fall time, thereby setting the spin texture in the magnetic layer.Type: ApplicationFiled: June 15, 2022Publication date: November 7, 2024Applicant: MAX PLANCK GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN EVInventors: Stuart S.P. PARKIN, Banabir PAL, Binoy KRISHNA HAZRA, See-Hun YANG
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Patent number: 12135405Abstract: An optical component comprising a planar metasurface arranged on a surface of a first substrate and a top layer arranged in a height direction Z above the metasurface, wherein the metasurface comprises a plurality of scattering structures, wherein a dielectric material is deposited on a subset of the plurality of scattering structures, wherein an active media is sandwiched between the metasurface and the top layer, wherein an incident electromagnetic radiation is transmitted or reflected by the optical component, wherein a phase profile modulation is induced on the incident electromagnetic radiation during the reflection or transmission.Type: GrantFiled: November 13, 2020Date of Patent: November 5, 2024Assignee: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.Inventors: Laura Na Liu, Jianxiong Li