Abstract: A method (1) for preparing a laser marking system (100) to create a colored laser mark on a specimen comprising the following steps: a) Providing a laser marking system (100) and a specimen (105) comprising a surface layer (105a), wherein the laser marking system comprises a preset number of laser parameters (12); b) Performing an exploration of a first gamut (2) specified by the laser marking system (100) and the specimen (105) comprising a surface layer (105a) including the following steps: aa) Creating (3) a design space (10) with a preset number of design points (11), wherein each design point (11) represents a combination of the preset number of laser parameters (12); bb) Performing (4) a marking of a sample on the specimen (105) for each design point (11); cc) Measuring (5) the sample using at least one detection device (106) and deter-mine for each design point a performance point (14), wherein the measured performance points (14) define a performance space (13); dd) Evaluating (6) the performance spac

Abstract: A classifying device for classifying cells in real-time, comprising: as alignment unit configured to align a cell to be classified along the cell's major axis; and a classifying unit configured to classify the aligned cell using a multilayer perceptron, MLP; wherein the MLP classifies the aligned cell based on one or more images of the aligned cell. By executing the classifying device, an improved and efficient cell classification in real-time based on cell images can be provided, while labelling of the cells to be classified can be avoided.

Abstract: The invention relates to an arrangement of electrical conductors, comprising a conductor bundle having at least one individual electrical cable and at least one cooling line through which a cooling fluid is to flow. In order to thermally connect the conductor bundle to the at least one cooling line, a portion of the at least one cooling line and the conductor bundle are embedded in a low melt temperature metal, wherein an insulating sheath of the at least one individual cable is embodied as plastic insulation, preferably as polyimide insulation or as polyester insulation. The invention further relates to a method for manufacturing such an arrangement.

Abstract: The present invention relates to immunogenic compositions and their use in the prevention or treatment of diseases or disorders caused by or associated with Helicobacter pylori, in particular H. pylori infection and gastroduodenal disorders caused by H. pylori. The present invention further relates to methods of detecting H. pylori infection in a subject.

Abstract: The present invention relates to a compound represented by formula (E). The present invention also relates to a compound represented by the formula (E) for use in the treatment or prevention of diseases linked to protein aggregation and/or neurodegenerative diseases. Moreover, the present invention relates to pharmaceutical and diagnostic compositions comprising the compound of the invention as well as to a kit. Furthermore, the present invention relates to a method of imaging deposits of aggregated protein. A kit for preparing a detectably labelled compound of the present invention is also disclosed.

Abstract: A new spectroscopic technique and corresponding spectrometer for molecules in which optical radiation is used to shift the rotational/nuclear-spin energy levels of freely rotatable sample molecules, and in which these shifts are detected using probing radiation. This technique enables the determination of individual polarizability components and/or combinations of these and/or information about the constitution of a sample that follows from these. In particular, it can reveal the enantiomeric constitution of a chiral sample whilst yielding a non-vanishing signal even for a racemate. The technique may find particular use in the analysis of molecules that are chiral by virtue of their isotopic constitution and molecules with multiple chiral centres.

Abstract: The present invention relates to diazabicyclo[4.3.1]decane derivatives, pharmaceutically acceptable salts of these compounds and pharmaceutical compositions containing at least one of these compounds together with pharmaceutically acceptable carrier, excipient and/or diluents. Said diazabicyclo[4.3.1]decane derivatives can be used for prophylaxis and/or treatment of psychiatric disorders and neurodegenerative diseases, disorders and conditions.

Abstract: The present invention relates to diazabicyclo[4.3.1]decane derivatives, pharmaceutically acceptable salts of these compounds and pharmaceutical compositions containing at least one of these compounds together with pharmaceutically acceptable carrier, excipient and/or diluents. Said diazabicyclo[4.3.1]decane derivatives can be used for prophylaxis and/or treatment of psychiatric disorders and neurodegenerative diseases, disorders and conditions.

Abstract: The present invention is directed to a method for producing artemisinin having the formula from dihydroartemisinic acid in a continuous flow reactor using singlet oxygen as well as to the continuous flow reactor for producing artemisinin.

Abstract: The present invention relates to an apparatus and a method for fast and reliable online detection of triacetone triperoxide (TATP), with at least three differently coated HFF quartz crystal oscillator sensors (29).

Abstract: The present invention relates to an optically transparent conductive carbon-based film which is suitable for use as an electrode in optoelectronic devices etc. Further, the invention relates to a process for the production of the transparent conductive carbon film and the use thereof in electronic devices. Organic solar cells using transparent conductive carbon film as electrode display comparable performance with cells using ITO. These carbon films show high thermal and chemical stability, ultra-smooth surface, and good adhesion to substrates.

Abstract: The invention relates to a light source comprising a primary radiation source and a luminescent substance, and to a method for producing this light source. The invention relates, in particular, to a method for producing an electric light source using one or more luminescent substances emitting in the visible spectrum range, and at least one primary source emitting preferably in the UV range, and which is preferably, but not exclusively, an LED.

Abstract: The present invention relates to a pharmaceutical composition comprising (a) a polynucleotide comprising or consisting of a nucleotide sequence encoding a polypeptide with the amino acid sequence as set forth in SEQ ID NO: 2; (b) a polynucleotide comprising or consisting of a nucleotide sequence which is a fragment of a nucleotide sequence encoding the polypeptide with the amino acid sequence as set forth in SEQ ID NO: 2, wherein the polypeptide encoded by said polynucleotide has arteriogenic activity; (c) a polynucleotide comprising or consisting of a nucleotide sequence encoding a polypeptide, wherein said polypeptide exhibits at least 70% sequence identity with the sequence of the polypeptide encoded by the polynucleotide of (a) or (b) over the entire length, and wherein said polypeptide has arteriogenic activity; and/or (d) a polypeptide encoded by the polynucleotide of any one of (a) to (c).

Abstract: The invention relates to a device and a method for producing mono-, oligo- and/or polyborosilazanes that contain carbon. According to said method (i) a one-component precursor compound is reacted with ammonia or an organic amino in an aminolysis step, (ii) a reaction mixture is extracted at least once from the aminolysis in a continuous extraction step using an organic solvent, (iii) ammonia or a phase containing organoamine that accumulates during the extraction process is discarded, recovered or at least partly recirculated and (iv) mono-, oligo- and/or polyborosilazanes containing carbon are obtained from the extraction phase containing the solvent.

Abstract: The invention relates to a semiconductor structure, especially for use in a semiconductor detector. The semiconductor structure includes a weakly doped semiconductor substrate (HK) of a first or second doping type, a highly doped drain region (D) of a second doping type, located on a first surface of the semiconductor substrate (HK), a highly doped source region (S) of the second doping type, located on the first surface of the semiconductor substrate (HK), a duct (K) extending between the source region (S) and the drain region (D), a doped inner gate region (IG) of the first doping type, which is at least partially located below the duct (K), and a blow-out contact (CL) for removing charge carriers from the inner gate region (IG). According to the invention, the inner gate region (IG) extends in the semiconductor substrate (HK) at least partially up to the blow-out contact (CL) and the blow-out contact (CL) is located on the drain end relative to the source region (S).

Abstract: The present invention relates to a method of classifying an individual comprising analyzing the nucleic acid of a sample taken from said patient for nucleotide polymorphisms in a haplotype block comprising the gene encoding FKBP51 and/or determining the expression level of FKBP51 in said sample. In a preferred embodiment, the invention provides a method of predicting the response to antidepressant therapy. Furthermore, a method of developing an anti-depressant drug, and pharmaceutical compositions are provided.

Abstract: The invention relates to a method for producing hollow fibres, in particular for producing meso- and nanotubes, whose tubes or hollow fibres have an internal diameter in the nano- to micrometre range and are preferably aligned in one direction. The invention also relates to the use of said hollow fibres, to hollow fibres or tubes produced by said method and to composite materials containing the hollow fibres or tubes.