Patents Assigned to Max Planck Institute
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Publication number: 20220237905Abstract: A method and system for training a model for image generation. The model includes a hybrid variational auto-encoder (VAE)—generative adversarial network (GAN) framework. The method includes the steps of: multiple input of an input image into the VAE which outputs in response multiple distinct output image samples, determining the best of the multiple output image samples as a best-of-many sample, the best-of-many sample having the minimum reconstruction cost, and training the model based on a predefined training objective, the predefined training objective integrating the best-of-many sample reconstruction cost and a GAN-based synthetic likelihood term.Type: ApplicationFiled: May 28, 2019Publication date: July 28, 2022Applicants: TOYOTA MOTOR EUROPE, MAX-PLANCK-INSTITUT FÜR INFORMATIKInventors: Daniel OLMEDA REINO, Apratim BHATTACHARYYA, Mario FRITZ, Bernt SCHIELE
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Patent number: 10851130Abstract: The present disclosure discloses the chemical synthesis method of the Plesiomonas shigelloides serotype O51 O-antigen oligosaccharide, belonging to the field of chemistry. Source-abundant D-glucose, L-fucose, D-glucosamine and the like are used as raw materials to prepare three glycosylation building blocks, the synthetic route composed of 11 reaction modules is designed, and through the optimization of protecting group and the optimization of the time of introducing functional group, the preparation of the target oligosaccharide chain is successfully achieved. The oligosaccharide chain prepared in the present disclosure has the advantages of cheap and easy-to-get raw materials, and simple and easy-to-repeat preparation method. The present disclosure will have good application prospects in the aspects of development of new drugs and vaccines of Plesiomonas shigelloides, and the like.Type: GrantFiled: December 10, 2018Date of Patent: December 1, 2020Assignees: Jiangnan University, Max Planck Institute of Colloids and InterfacesInventors: Jian Yin, Jing Hu, Peter Seeberger, Chunjun Qin
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Patent number: 10544481Abstract: The invention relates to a method for the recovery of precious metal from materials containing precious metal, said method comprises the following steps of: A) bringing the materials containing the precious metal into contact with an oxidizing agent, B) bringing the material containing the precious metal into contact with a reducing agent. Said method offers the possibility of recovering precious metal in a simple manner and in high purity from secondary materials.Type: GrantFiled: October 25, 2016Date of Patent: January 28, 2020Assignee: Max-Planck-Institut für Eisenforschung GmbHInventors: Nejc Hodnik, Claudio Baldizzone, Karl Mayrhofer
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Patent number: 10512605Abstract: The present disclosure discloses an integrated nano system for liver-targeting co-delivery of genes/drugs and a preparation method, belonging to the field of biomedicines. In the disclosure, a plurality of functions are integrated in a carrier having good biocompatibility and safety, a nucleic acid/drug-loading copolymer portion having a pH-stimulating response function is formed by poly(N,N-dimethylaminoethyl methacrylate) (PDMAEMA) grafted with poly(3-azido-2-hydroxypropylmethacrylate) (PGMA-N3), and a fluorescence-based imaging component Rhodamine B (RhB) and galactose are used as targeting ligands. The drug delivery system provided by the present disclosure is safe, is capable of taking a synergistic effect of gene/drug therapy, and is expected to play a great role in clinical application.Type: GrantFiled: December 10, 2018Date of Patent: December 24, 2019Assignees: Jiangnan University, Max Planck Institute of Colloids and InterfacesInventors: Jian Yin, Jing Hu, Peter Seeberger, Zhou Ye
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Publication number: 20190032161Abstract: The invention provides a reliably manufacturable flat steel product based on a Fe3Al alloy and a method that allows the production of such flat steel products. For this purpose, the flat steel product is made of a steel which comprises (in % by weight) Al: 12-20%, Ti: 0.2-2%, B: 0.1-0.6%, in each case at least one element from the group “Cr, C, Mn, Si, Nb, Ta, W, Zr, V, Mo, Ni, Cu, Ca, rare earth metals, and Co” unavoidable impurities. The method according to the invention specifies that a molten steel with the stated composition is cast as a precursor in the form of a slab, thin slab or a cast strip, the precursor is then hot rolled into a hot strip.Type: ApplicationFiled: January 20, 2016Publication date: January 31, 2019Applicants: ThyssenKrupp Steel Europe AG, thyssenkrupp AG, Max-Planck-Institut für Eisenforschung GmbHInventors: Harald HOFMANN, Hans FERKEL, Michael GÖVERT, Matthias SCHIRMER, Martin PALM, Dirk PONGE, Andreas LEITNER
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Patent number: 9915614Abstract: Methods, systems, and devices are disclosed for molecular capture, manipulation, and analysis. In one aspect, a device to aggregate and characterize particles in a fluid includes an electrically insulative substrate including a channel to carry an electrically conducting fluid containing particles, electrodes located in the channel forming a nanoscale opening and including an insulating layer over their surface at the opening, a first circuit to apply a non-uniform ac electric field and a dc bias signal across the electrodes, in which the applied non-uniform ac electric field produces a positive dielectrophoretic force to aggregate the particles in a trapping region including the opening and adjacent region, a second circuit to detect changes in a dc current caused by at least some of the particles in the trapping region, and an optical device that directs a coherent light beam on the opening to determine Raman spectra of the particles in the trapping region.Type: GrantFiled: April 26, 2013Date of Patent: March 13, 2018Assignees: ACADEMIA SINICA, MAX-PLANCK-INSTITUT FUR EISENFORSCHUNG GMBHInventors: Chia-Fu Chou, Lesser-Rojas Leonardo, Ming-Lee Chu, Andreas Erbe
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Publication number: 20180064712Abstract: The present invention encompasses methods of reducing inflammatory immune cell activation and inflammation via inhibiting mitochondrial fission.Type: ApplicationFiled: June 8, 2017Publication date: March 8, 2018Applicant: Max Planck InstituteInventors: Erika L. Pearce, Michael D. Buck, David O'Sullivan, Francesc Baixauli
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Publication number: 20140320849Abstract: Methods, systems, and devices are disclosed for molecular capture, manipulation, and analysis. In one aspect, a device to aggregate and characterize particles in a fluid includes an electrically insulative substrate including a channel to carry an electrically conducting fluid containing particles, electrodes located in the channel forming a nanoscale opening and including an insulating layer over their surface at the opening, a first circuit to apply a non-uniform ac electric field and a dc bias signal across the electrodes, in which the applied non-uniform ac electric field produces a positive dielectrophoretic force to aggregate the particles in a trapping region including the opening and adjacent region, a second circuit to detect changes in a dc current caused by at least some of the particles in the trapping region, and an optical device that directs a coherent light beam on the opening to determine Raman spectra of the particles in the trapping region.Type: ApplicationFiled: April 26, 2013Publication date: October 30, 2014Applicants: MAX-PLANCK-INSTITUT FÜR EISENFORSCHUNG GMBH, ACADEMIA SINICAInventors: Chia-Fu Chou, Lesser-Rojas Leonardo, Ming-Li Chu, Andreas Erbe
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Publication number: 20130338744Abstract: Graphene, can be used to make an implantable neuronal prosthetic which can be indefinitely implanted in vivo. Graphene electrodes are placed on a 3C—SiC shank and electrical insulation is provided by conformal insulating SiC. These materials are not only chemically resilient, physically durable, and have excellent electrical properties, but have demonstrated a very high degree of biocompatibility. Graphene also has a large specific capacitance in electrolytic solutions as well as a large surface area which reduces the chances for irreversible Faradaic reactions. Graphene can easily be constructed on SiC by the evaporation of Si from the surface of that material allowing for mechanically robust epitaxial graphene layers that can be fashioned into electrodes using standard lithography and etching methods.Type: ApplicationFiled: May 30, 2013Publication date: December 19, 2013Applicants: Max-Planck-Institute for Solid State Research, University of South FloridaInventors: Christopher Leroy Frewin, Stephen E. Saddow, Camilla Coletti
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Publication number: 20120000580Abstract: A corrosion-resistant austenitic steel is claimed which, in each case relative to 100 mass percent, contains 20 to 32% manganese, 10 to 15% chromium, a total of 0.5 to 1.3% carbon and nitrogen, wherein the ratio of carbon to nitrogen is 0.5 to 1.5, the remainder being iron and melt-related impurities. The claimed steel can be produced and processed at normal pressure and has TWIP properties. It is in particular suited for producing structural components in constructs, such as in the automotive industry.Type: ApplicationFiled: March 3, 2010Publication date: January 5, 2012Applicant: MAX-PLANCK-INSTITUT FUER EISENFORSCHUNG GMBHInventors: Sebastian Weber, Lais Mujica Roncery
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Patent number: 7806165Abstract: In a method for making hot strips, a workable lightweight construction steel is used which in particular can easily be deep-drawn cold and includes the main elements Si, Al and Mn, with high tensile strength and good TRIP and/or TWIP characteristics. The mass % are as follows for C 0.04 to <1.0, Al 0.05 to <4.0, SI 0.05 to ?6.0; Mn 9.0 to ?30.0, the remainder being iron with the common incidental steel elements. The melt is cast in a horizontal strip casting unit, close to the final dimensions at calm flow and without bending to form a pre-strip in the range between 6 and 15 mm, and subsequently is fed for further processing.Type: GrantFiled: December 22, 2004Date of Patent: October 5, 2010Assignees: Salzgitter Flachstahl GmbH, Max-Planck-Institut Für Eisenforschung GmbHInventors: Joachim Kroos, Karl-Heinz Spitzer, Georg Frommeyer, Volker Flaxa, Udo Brüx, Klaus Brockmeier
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Publication number: 20100064384Abstract: The invention relates to a method of modifying the ATP-ADP ratio in a cell, tissue, organ, microorganism or plant by altering the hemoprotein activity in the cell, and to the use of the method.Type: ApplicationFiled: March 20, 2007Publication date: March 11, 2010Applicant: Max Planck Institut fur molekulareInventor: Thorsten Zank
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Publication number: 20100037350Abstract: This invention relates generally to plant cells and/or plants with increased yield as compared to a corresponding non-transformed wild type plant cell by increasing or generating one or more activities of polypeptides associated with the intermediate phosphoribosylpyrophosphate (PRPP) in plants. In particular, this invention relates to plant cells and/or plants with increased yield as compared to a corresponding non-transformed wild type plant cell by increasing or generating one or more activities of phosphoribosyl pyrophosphate synthases (PRPP synthetase, PRS) The invention also deals with methods of producing and screening for and breeding such plant cells and/or plants.Type: ApplicationFiled: October 12, 2007Publication date: February 11, 2010Applicants: BASF Plant Science GmbH, Max-Planck-Institut fuer Molekulare PflanzenphysiologieInventors: Thorsten Zank, Oliver Oswald, Jörg Bauer, Rita Maria Zrenner, Silke Koslowsky
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Publication number: 20090251765Abstract: The present invention relates to a composition for photon energy up-conversion, a system comprising said composition and to uses of said composition and said system.Type: ApplicationFiled: April 8, 2008Publication date: October 8, 2009Applicants: Max-Planck-Institut fur Polymerforschung, Sony Deutschland GmbHInventors: Tzenka MITEVA, Gabriele Nelles, Akio Yasuda, Stanislav Balouchev, John Lupton, Panagiotis Keivanidis
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Patent number: 7411396Abstract: An MRI apparatus is presented that includes a computer programmed to sample a single volume element (voxel) for MR spectroscopy and automatically determine respective metabolite concentrations for multiple compartment contained in the single voxel. The invention is effective in assigning metabolite concentrations to specific tissue types on a per-voxel basis for a VOI. Moreover, the invention is effective in providing metabolite concentrations for a voxel independent of that voxel's vicinity relative to the coils of the phased array. The present invention provides an effective tool in assigning metabolite concentrations from mixed pathological and normal tissues.Type: GrantFiled: May 8, 2006Date of Patent: August 12, 2008Assignees: General Electric Company, Max-Planck-Institut fur PsychiatrieInventors: Timo Schirmer, Michael Czisch
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Publication number: 20050137132Abstract: The present invention is directed to kappaM (?M) conopeptide RIIIK and its use for blocking the flow of potassium ions through voltage-gated potassium channels. The ?M conopeptides include unglycosylated and O-glycosylated peptides.Type: ApplicationFiled: July 16, 2004Publication date: June 23, 2005Applicants: University of Utah Research Foundation, Max Planck Institut for Experimental MedicineInventors: Baldomero Olivera, Maren Watkins, Heinrich Terlau, Michael Ferber
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Patent number: 6842704Abstract: A tumor necrosis factor-? converting enzyme (TACE) is produced, purified, and crystallized. The three-dimensional coordinates of the crystal are obtained by X-ray diffraction. The coordinates can be recorded on a computer readable medium, or are part of a video memory, where they can be used as part of a system for studying for studying TACE. The coordinates are also used in designing, screening, and developing compounds that associate with TACE.Type: GrantFiled: February 4, 1999Date of Patent: January 11, 2005Assignees: Immunex Corporation, Max-Planck-Institute for Biochemistry, WyethInventors: Roy A. Black, Raymond James Paxton, Wolfram Bode, Klaus Maskos, Carlos Fernandez-Catalan, James Ming Chen, Jeremy Ian Levin
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Patent number: 6663989Abstract: A structure containing a ferroelectric material comprises a substrate such as silicon, a buffer layer formed on the substrate, and a non-c-axis-oriented, electrically-conductive template layer formed on the buffer layer. The template layer comprises a perovskite oxide compound. An epitaxially a-axis-oriented ferroelectric layer is formed on the template layer, and has a vector of spontaneous polarization oriented perpendicular or at least substantially perpendicular to the film normal.Type: GrantFiled: March 28, 2002Date of Patent: December 16, 2003Assignee: Max-Planck-Institut fur MikrostrukturphysikInventors: Ho Nyung Lee, Stephan Senz, Alina Visinoiu, Alain Pignolet, Dietrich Hesse, Ulrich Gösele
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Patent number: 6531235Abstract: A structure containing a ferroelectric material comprises a substrate comprising silicon, a buffer layer formed on the substrate, and a non-c-axis-oriented, electrically-conductive template layer formed on the buffer layer. The template layer comprises a perovskite oxide compound. A non-c-axis-oriented, anisotropic perovskite ferroelectric layer is formed on the template layer.Type: GrantFiled: June 6, 2001Date of Patent: March 11, 2003Assignee: Max-Planck-Institute für MikrostrukturphysikInventors: Ho Nyung Lee, Stephan Senz, Alina Visinoiu, Alain Pignolet, Dietrich Hesse, Ulrich Gösele
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Patent number: 6218468Abstract: In a process for the preparation of an aqueous polymer dispersion by the free radical aqueous emulsion polymerization method, the polymerization is carried out in the presence of frozen micelles of amphiphilic substances.Type: GrantFiled: July 22, 1998Date of Patent: April 17, 2001Assignees: BASF Aktiengesellschaft, Max-Planck-InstitutInventors: Klemens Mathauer, Walter Mächtle, Wolfgang Schrof, Horst Schuch, Timo Rager, Wolfgang Meyer, Gerhard Wegner