Patents Assigned to MAXCYTE, Inc.
  • A METHOD OF ENHANCED VIRAL TRANSDUCTION USING ELECTROPORATION
    Publication number: 20240401083
    Abstract: Method of cell-editing comprising combining a cell or cell line with a virus, viral vector or virus like particle to form a mixture and performing simultaneous electroporation and transduction on the mixture to insert therein the virus, viral vector or virus like particle. The disclosed method simultaneously causes the virus, viral vector or virus like particle to edit, remove or modify a cell or cell line and inserting a virus, viral vector or virus like particle therein. A modified cell or cell line made by the disclosed method is also disclosed.
    Type: Application
    Filed: September 26, 2022
    Publication date: December 5, 2024
    Applicant: MAXCYTE, INC.
    Inventors: Joan Hilly FOSTER, James BRADY
  • Engineering and delivery of therapeutic compositions of freshly isolated cells
    Patent number: 11331344
    Abstract: The present invention relates to the transient modification of cells. In particular embodiments, the cells are immune systems, such as PBMC, PBL, T (CD3+ and/or CD8+) and Natural Killer (NK) cells. The modified cells provide a population of cells that express a genetically engineered chimeric receptor which can be administered to a patient therapeutically. The present invention further relates to methods that deliver mRNA coding for the chimeric receptor to unstimulated resting PBMC, PBL, T (CD3+ and/or CD8+) and NK cells and which delivers the mRNA efficiently to the transfected cells and promotes significant target cell killing.
    Type: Grant
    Filed: October 6, 2017
    Date of Patent: May 17, 2022
    Assignee: MAXCYTE INC.
    Inventors: Linhong Li, Madhusudan V. Peshwa
  • METHODS FOR OPTIMIZING ELECTROPORATION
    Publication number: 20120088842
    Abstract: Embodiments of the invention are directed to a technique for electroporation that allows for a delivery of long electrical pulses of high magnitude in highly conductive buffers and minimizes damage to cells undergoing electroporation.
    Type: Application
    Filed: July 15, 2009
    Publication date: April 12, 2012
    Applicant: MAXCYTE, INC.
    Inventor: Sergey Dzekunov
  • Apparatus and method for flow electroporation of biological samples
    Patent number: 7029916
    Abstract: The present invention relates to methods and apparatus for the encapsulation of biologically-active substances in various cell populations. More particularly, the present invention relates to a method and apparatus for the encapsulation of biologically-active substances in various cell populations in blood by electroporation to achieve therapeutically desirable changes in the physical characteristics of the various cell populations in blood.
    Type: Grant
    Filed: February 21, 2002
    Date of Patent: April 18, 2006
    Assignee: MAXCYTE, Inc.
    Inventors: Sergey M. Dzekunov, Hyung J. Lee, Linhong Li, Vininder Singh, Linda Liu, John W. Holaday
  • Apparatus and method for electroporation of biological samples
    Publication number: 20040197883
    Abstract: The present invention relates to methods and apparatus for the encapsulation of biologically-active substances in various cell populations. More particularly, the present invention relates to a method and apparatus for the encapsulation of biologically-active substances in various cell populations in blood by electroporation to achieve therapeutically desirable changes in the physical characteristics of the various cell populations in blood.
    Type: Application
    Filed: January 5, 2004
    Publication date: October 7, 2004
    Applicant: MAXCYTE, Inc.
    Inventors: Sergey M. Dzekunov, Linhong Li, Vininder Singh, Linda Liu, John W. Holaday, Hyung J. Lee
  • Bag used for sample or collection
    Patent number: D1066728
    Type: Grant
    Filed: September 30, 2022
    Date of Patent: March 11, 2025
    Assignee: MAXCYTE, INC.
    Inventors: Nicholas Chopas, Matthew Appleman