Abstract: A computer-implemented method for registering low dimensional images with a high dimensional image includes receiving a high dimensional image of a region of interest and simulating synthetic low dimensional images of the region of interest from a number of poses of a virtual low dimensional imaging device, from the high dimensional image. The method determines positions of landmarks within the low dimensional images by applying a first learning algorithm to the low dimensional images and back projecting of the positions of the determined landmarks into the high dimensional image space, to thereby obtain the positions of the landmarks in the high dimensional image. The positions of landmarks within low dimensional images acquired form an imaging device are determined by applying the first or a second learning algorithm to the low dimensional images. The low dimensional images are registered with the high dimensional image based on the positions of the landmarks.

Abstract: An illumination apparatus (1) for illuminating the operating field during open surgery with radiation to cause fluorescence, the apparatus including a main body (2) including an opening (3) configured to release the radiation (18), is characterized by an attachment unit or assembly (4) for removably attaching the main body (2) sideways to an endoscope (5).

Abstract: A computer-implemented method for registering low dimensional images with a high dimensional image includes receiving a high dimensional image of a region of interest and simulating synthetic low dimensional images of the region of interest from a number of poses of a virtual low dimensional imaging device, from the high dimensional image. The method determines positions of landmarks within the low dimensional images by applying a first learning algorithm to the low dimensional images and back projecting of the positions of the determined landmarks into the high dimensional image space, to thereby obtain the positions of the landmarks in the high dimensional image. The positions of landmarks within low dimensional images acquired form an imaging device are determined by applying the first or a second learning algorithm to the low dimensional images. The low dimensional images are registered with the high dimensional image based on the positions of the landmarks.