Abstract: Computer-implemented methods for managing communication between each of the plurality of wireless RF nodes and a base station using frequency hopping over M non-overlapping frequency channels in a wireless network is provided. The communication is carried out according to a time slot schedule comprising M time slot assemblies, each time slot assembly comprising at least one time slot for the base station to transmit, preferably by broadcast, data on a different channel of the M channels, and R time slots, R being an integer equal to or greater than 1, for one or more of the plurality of nodes to transmit data to the base station. The methods described herein enable a point-to-multipoint wireless communication system in an ISM frequency band that can provide a reliable RF data link even in an area that already comprises one or more WLAN networks that operate in the same ISM frequency band.