Abstract: The present invention discloses a Plectin-1 receptor targeting novel cationic KTLLPTPK(SEQ ID NO: 1)-lipopeptide. The present invention further discloses a liposomal formulation comprising the cationic KTLLPTPK(SEQ ID NO: 1)-lipopeptide, at least two co-lipids, a therapeutic agent, and a pharmaceutically acceptable carrier. The present invention also provides a method for regressing established pancreatic tumors comprising administering a therapeutically effective amount of the liposomal formulation with the therapeutic agents in combination with targeted genetic immunization (DNA vaccination) i.e. by immunizing mice with electrostatic complexes (direct in-vivo DC-targeting cationic liposomes) of DNA vaccines encoding mesothelin (p-CMV-MSLN).

Abstract: The present invention refers to a newly discovered gene named KASPP for Kinase Associated with Parkinsonism with Pleiomorphic Pathology or alternatively named LRRK2 for Leucine-Rich Repeat Kinase 2, its production, biochemical characterization and use for the detection and treatment of neurodegenerative disorders, such as Parkinson disease (PD) including, without limitation, sporadic PD, Alzheimer disease (AD), amyotrophic lateral sclerosis (ALS), and other synucleinopathies and/or tauopathy as well as several polymorphisms and mutations in the KASPP/LRRK2 gene segregated with PD.

Abstract: An adaptive interactive preceptored teaching system for the remote education of a student provides lessons, obtains the student's profile, uses the profile to select one of the lessons to be sent to the student, and sends that lesson to the student. A method for remote care of a diabetic patient involves providing lessons, obtaining the patient's profile, using the profile to select a lesson to be sent to the patient, sending that lesson to the patient, offering the patient information reflecting the patient's health, and offering the patient's healthcare provider information regarding at least one of the patient's study of the lesson, the patient's health, and the patient's medical appointments. Communication can take place via the Internet, and can be effected in a secure manner.

Abstract: The present invention includes a method and apparatus to correct for gradient field distortions. The invention is particularly applicable in moving table imaging where a single extended image is desirable. The invention includes acquiring MR data in motion in the presence of gradient non-linearities, transforming the MR data acquired into the image domain, and then applying a warping correction function to the transformed MR data. The warp-corrected MR data is then corrected for motion induced during the MR acquisition. The data may be acquired point-by-point, line-by-line, or another sub-portion of the entire MR data acquired, and processed to minimize the amount of motion correction needed. Based on table velocity or acquisition sequence applied, the data is partitioned based on a common motion correction factor, and after correcting for motion, the data is accumulated to build up a final image.

Abstract: The present invention includes a method and apparatus to correct for gradient field distortions. The invention is particularly applicable in moving table imaging where a single extended image is desirable. The invention includes acquiring MR data in motion in the presence of gradient non-linearities, transforming the MR data acquired into the image domain, and then applying a warping correction function to the transformed MR data. The warp-corrected MR data is then corrected for motion induced during the MR acquisition. The data may be acquired point-by-point, line-by-line, or another sub-portion of the entire MR data acquired, and processed to minimize the amount of motion correction needed. Based on table velocity or acquisition sequence applied, the data is partitioned based on a common motion correction factor, and after correcting for motion, the data is accumulated to build up a final image.