Patents Assigned to Mayo Foundation for Medical Education
  • Publication number: 20210373023
    Abstract: This document provides methods and materials involved in identifying mammals (e.g., humans) having cancer cells with an elevated level of phosphorylated Ub polypeptides (e.g., an elevated level of Y59 phosphorylated Ub polypeptides). For example, methods and materials for detecting the presence of cancer cells having an elevated level of Y59 phosphorylated Ub polypeptides are provided.
    Type: Application
    Filed: November 6, 2018
    Publication date: December 2, 2021
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Zhenkun Lou, Min Deng
  • Publication number: 20210369790
    Abstract: This document provides methods and materials for identifying and treating mammals responsive to obesity treatments. For example, methods and materials for assessing a mammal's gut microbiota (e.g., a human's gut microbiota) to identify that mammal (e.g., human) as being responsive to an obesity treatment are provided. Methods and materials for treating obesity by assessing a mammal's gut microbiota (e.g., a human's gut microbiota) to identify that mammal (e.g., human) as being responsive to an obesity treatment and proceeding with an obesity treatment also are provided.
    Type: Application
    Filed: September 16, 2018
    Publication date: December 2, 2021
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Michael D. Jensen, Vandana Nehra, Purna C. Kashyap
  • Patent number: 11186875
    Abstract: Various embodiments provide compositions and methods for detecting cancers containing an NRG1 fusion event and treating a patient with a therapeutic agent that is targeted to the NRG1 fusion. Exemplary compositions for treating cancers containing the NRG1 fusion may comprise therapeutic agents inhibiting Epidermal Growth Factor Receptor and/or ERBB2 such as cetuximab, panitumumab, Sym004, MM-151, mAb 806, mAb 528, MEHD794A, gefitinib, erlotinib, lapatinib, afatinib, PD153035, AG1478, trastuzumab, and pertuzumab. In some embodiments, the therapeutic agent may be a combination of trastuzumab, and pertuzumab.
    Type: Grant
    Filed: June 13, 2016
    Date of Patent: November 30, 2021
    Assignees: The Translational Genomics Research Institute, Mayo Foundation for Medical Education and Research
    Inventors: John Carpten, David Craig, Sara Byron, Jessica Aldrich, Mitesh Borad, Alan Bryce, Michael Barrett, George Vasmatzis, Keith Stewart
  • Publication number: 20210361217
    Abstract: Systems, methods, devices, and other techniques for estimating the age and sex of a person through analysis of an electrocardiogram (ECG) recording for the person. Some aspects include recording an ECG of a person, processing data representing the ECG with an age-estimation neural network to generate an estimated age of the person, and outputting an indication of the estimated age of the person. Other aspects include processing the ECG with a sex prediction neural network to generate a predicted sex of the person and outputting an indication of the predicted sex of the person.
    Type: Application
    Filed: January 11, 2019
    Publication date: November 25, 2021
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Itzhak Zachi Attia, Paul A. Friedman, Suraj Kapa, Francisco Lopez-Jimenez
  • Patent number: 11179270
    Abstract: Devices and methods are provided for the treatment of pathological conditions including arrhythmias and trauma using temperature modulation via implantable or worn devices. For example, in one example embodiment this document relates to devices and methods for treating atrial or ventricular fibrillation by cooling the epicardium. The devices and methods can also be used to treat other disorders by applying heating and/or cooling to a patient in a number of different manners.
    Type: Grant
    Filed: December 2, 2016
    Date of Patent: November 23, 2021
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Samuel J. Asirvatham, Paul A. Friedman, Douglas S. Beinborn
  • Patent number: 11180543
    Abstract: The invention provides methods for the treatment of neonatal hypoxia and associated white matter disease or injury, particularly in infant, including neonatal, animals, particularly Periventricular Leukomalacia (PVL) comprising administering one or more CNS reactive antibody, particularly selected from IgM12, IgM22, IgM42 and IgM46. Compositions for use in treatment of white matter disease or injury in infants, particularly PVL are provided. The invention provides methods for alleviation of neuromotor or neurodevelopmental deficits associated with neonatal hypoxia and associated with white matter injury, including PVL, in an infant.
    Type: Grant
    Filed: November 6, 2015
    Date of Patent: November 23, 2021
    Assignee: Mayo Foundation For Medical Education and Research
    Inventors: Jens O. Watzlawik, Arthur E. Warrington, Moses Rodriguez, William A. Carey
  • Patent number: 11172910
    Abstract: Methods for measuring mechanical properties of an object or subject under examination with an ultrasound system and using unfocused ultrasound energy are provided. Shear waves that propagate in the object or subject are produced by applying unfocused ultrasound energy to the object or subject, and measurement data is acquired by applying focused or unfocused ultrasound energy to at least one location in the object or subject at which shear waves are present Mechanical properties are then calculated from the acquired measurement data.
    Type: Grant
    Filed: February 27, 2012
    Date of Patent: November 16, 2021
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: James F. Greenleaf, Shigao Chen, Armando Manduca, Pengfei Song
  • Publication number: 20210342520
    Abstract: This document provides systems and methods for altering text presentation to increase reading accuracy, efficiency, and retention. This can include identification text specific attributes from machine readable text (through parsing of the text), varying the text presentation in accordance with the attributes, and creating an enhanced visual product for enhancing the reading experience. For example, a computer system can extract attributes such as parts of speech from an input sentence and display that sentence in cascading text segments down and across a display screen. The system can further use domain-specific dictionaries derived from domain-specific texts to identify domain-specific compound noun phrases and verb phrases that require specific linguistic tagging to be usable in other linguistic analysis steps.
    Type: Application
    Filed: July 14, 2021
    Publication date: November 4, 2021
    Applicant: Mayo Foundation for Medical Education and Research
    Inventor: Randall C. Walker
  • Patent number: 11160876
    Abstract: Described herein are compositions of binding agents and carrier proteins, and at least one therapeutic agent, wherein the binding agents are capable of binding an antigen expressed on T-cells and methods of making and using the same, in particular, as a T-cell cancer therapeutic. Also described are lyophilized compositions of binding agents and carrier proteins, and at least one therapeutic agent, and methods of making and using the same, in particular, as a T-cell cancer therapeutic.
    Type: Grant
    Filed: August 31, 2017
    Date of Patent: November 2, 2021
    Assignee: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventors: Svetomir N. Markovic, Wendy K. Nevala
  • Patent number: 11161814
    Abstract: Compounds and compositions that can modulate mitochondrial function in neuronal cells are provided herein, as are methods for using the compounds and compositions to treat or prevent conditions such as Alzheimer's disease. For example, compounds of Formula I, compositions containing the compounds, and methods for using the compounds and compositions are provided herein: wherein X is absent, CH2, or C(O); R1 is H, OH, CN, NO2, halo, C1-3 alkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C3-7 cycloalkyl, amino, C1-3 alkylamino, or di(C1-3 alkyl)amino; R2 is H or C1-6 alkyl; R3 is H, C1-6 alkyl, —C(O)(C1-3 alkyl), or —C(O)O(C1-3 alkyl); R4 is C3-10 cycloalkyl, C6-10 aryl, 5-10 membered heteroaryl, or 5-10 membered heterocycloalkyl, each optionally substituted by 1, 2, 3, or 4 independently selected R5 groups; and R5 is OH, CN, NO2, halo, C1-3 alkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C3-7 cycloalkyl, amino, C1-3 alkylamino, or di(C1-3 alkyl)amino.
    Type: Grant
    Filed: August 25, 2020
    Date of Patent: November 2, 2021
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Eugenia Trushina, Robert Greenhouse, Kevin Greenman, William Thomas
  • Patent number: 11154718
    Abstract: This document provides methods and materials involved in detecting and delivering neurochemical signals, electrophysiological signals, ions, or combinations thereof within a mammal. For example, systems that can include one or more implantable devices containing probes configured to detect neurochemical signals (e.g., neurotransmitter concentrations), electrical signals, ions, or combinations thereof and one or more implantable devices containing electrodes and/or microfluidic delivery components configured to deliver neurochemical signals (e.g., neurotransmitters), electrical signals, ions, or combinations thereof to one or more locations within a mammal are provided.
    Type: Grant
    Filed: October 11, 2019
    Date of Patent: October 26, 2021
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Kevin E. Bennet, Kendall H. Lee
  • Patent number: 11154404
    Abstract: A spinal fixation system includes an expandable disc replacement body and an adjustment mechanism. The expandable disc replacement body includes a first wall, a second wall, a hinge connecting the first wall and the second wall, and a first bone-screw receiving section at a proximal end of the first wall. The adjustment mechanism is positioned between the first wall and the second wall, and an angle between the first wall and the second wall can be varied by movement of the adjustment mechanism.
    Type: Grant
    Filed: September 8, 2017
    Date of Patent: October 26, 2021
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Brett Freedman, April V. Krivoniak, Kendall D. Dennis
  • Patent number: 11154233
    Abstract: An apparatus and computerized method of classifying a wide complex heart beat(s) comprising: providing a computing device having an input/output interface, one or more processors and a memory; receiving one or more wide complex heart beat waveform amplitudes and/or time-voltage areas, and one or more baseline heart beat waveform amplitudes and/or time-voltage areas via the input/output interface or the memory; determining a signal change between the wide complex heart beat waveform amplitudes and/or time-voltage areas and the baseline heart beat waveform amplitudes and/or time-voltage areas using the one or more processors; and providing the signal change via the input/output interface, wherein the signal change provides an indication whether the wide complex heart beat(s) is from a ventricular source or a supraventricular aberrant condition.
    Type: Grant
    Filed: June 18, 2019
    Date of Patent: October 26, 2021
    Assignee: Mayo Foundation for Medical Education and Research
    Inventor: Adam M. May
  • Publication number: 20210324032
    Abstract: Analogues of an alternatively spliced form of atrial natriuretic peptide (MANP) that exhibit pGC-A gain of function and can be used to treat cardiorenal and metabolic disease are described herein.
    Type: Application
    Filed: June 25, 2021
    Publication date: October 21, 2021
    Applicant: Mayo Foundation for Medical Education and Research
    Inventor: John C. Burnett, Jr.
  • Patent number: 11149286
    Abstract: This document provides adenovirus vectors and methods and materials related to using adenovirus vectors. For example, adenoviruses for delivering nucleic acid encoding one or more immunogens (e.g., one or more immunogens associated with a pathogen causing an infection) to cells within a mammal such that the mammal produces an effective immune response against the immunogen(s) are provided.
    Type: Grant
    Filed: August 18, 2020
    Date of Patent: October 19, 2021
    Assignee: Mayo Foundation for Medical Education and Research
    Inventor: Michael A. Barry
  • Patent number: 11141432
    Abstract: Provided herein are materials and methods for treating a cancer and/or an infection in a mammal. One or more mitochondrial protein uncoupling protein 2 (UCP2) inhibitors can be administered to a mammal to enhance an immune response produced against an antigen (e.g., a tumor associated antigen or a pathogen associated antigen) present within the mammal.
    Type: Grant
    Filed: March 2, 2017
    Date of Patent: October 12, 2021
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Protul Shrikant, Leena Chaudhuri
  • Patent number: 11143767
    Abstract: Described here are systems and methods for optimization techniques for automatically selecting x-ray beam spectra, energy threshold, energy bin settings, and other imaging technique parameters for photon-counting detector computed tomography (“PCCT”). The techniques described here are generally based on subject or object size, material of interest, and location of the target material. Advantageously, the optimizations can be integrated with different PCCT systems to automatically select optimal imaging technique parameters before scanning a particular subject or object.
    Type: Grant
    Filed: June 25, 2020
    Date of Patent: October 12, 2021
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Cynthia H. McCollough, Zhoubo Li, Shuai Leng
  • Patent number: 11141470
    Abstract: This document provides methods and materials involved in reducing cardiac xenograft rejection. For example, methods and materials for preparing transgenic pigs expressing reduced or no endogenous Sda or SDa-like glycans derived from the porcine ?1,4 N-acetyl-galactosaminyl transferase 2 (B4GALNT2) glycosyltransferase and/or reduced or no endogenous ?-Gal antigens, methods and materials for modifying the xenograft recipient's immunological response to non-Gal antigens (e.g. CD46, CD59, CD9, PROCR, and ANXA2) to reduce cardiac xenograft rejection, and methods and materials for monitoring the progress of xenotransplant immunologic rejection are provided.
    Type: Grant
    Filed: April 24, 2017
    Date of Patent: October 12, 2021
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Christopher G. A. McGregor, Guerard W. Byrne
  • Patent number: 11143653
    Abstract: This document provides methods and materials involved in assessing immune system profiles. For example, methods and materials for performing flow cytometry to determine the number of CD4+ lymphocytes, CD8+ lymphocytes, regulatory T cells, B cells, NK cells, granulocytes, CD14+HLA-DRlo/neg g monocytes, and/or CD86+ monocytes per unit volume (e.g., cells per ?L or mL) of whole blood (e.g., fresh, un-manipulated whole blood) obtained from a mammal (e.g., a human) are provided.
    Type: Grant
    Filed: April 13, 2018
    Date of Patent: October 12, 2021
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Allan B. Dietz, Michael P. Gustafson
  • Publication number: 20210307824
    Abstract: A method and device for modulating the autonomic nervous system adjacent a pericardial space to treat cardiac arrhythmia includes a treatment source arranged to supply a treatment medium, a catheter having an end sized for insertion into the pericardial space, a medium delivery assembly having a distal end arranged to be positioned by the catheter into the pericardium, with the distal end of the delivery assembly comprising a delivery tip arranged to extend away from the distal end of the catheter into the pericardial space. A connector operatively couples the delivery tip of the medium delivery assembly to the treatment source, and the delivery tip of the medium delivery assembly including a plurality of delivery points for delivering the treatment medium at a plurality of treatment areas within the pericardial space. The device performs modulation or ablation of the autonomic nervous system at selected treatment areas within the pericardium.
    Type: Application
    Filed: June 17, 2021
    Publication date: October 7, 2021
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Samuel J. Asirvatham, Mark B. Knudson