Patents Assigned to Mayo Foundation for Medical Education and Research , a Minnesota corporation
-
Publication number: 20090155884Abstract: The invention provides methods and materials involved in displaying polypeptide sequences using viruses such as avian leukosis viruses. Specifically, the invention provides nucleic acid molecules, collections of nucleic acid molecules, polypeptides, collections of polypeptides, viruses, and collections of viruses as well as methods for making nucleic acid molecules, collections of nucleic acid molecules, polypeptides, collections of polypeptides, viruses, and collections of viruses. The invention also provides methods for obtaining displayed polypeptide sequences that interact with biological molecules and/or cells as well as methods for identifying biological molecules that interact with displayed polypeptides.Type: ApplicationFiled: October 8, 2008Publication date: June 18, 2009Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH , a Minnesota corporationInventors: Mark J. Federspiel, Stephen J. Russell, Pranay D. Khare
-
Publication number: 20060039930Abstract: Abstract of the Disclosure A method for treating a patient having a wound is described. The method includes administering an amount of a chemodenervating agent such that healing of the wound is enhanced. The method is illustrated by detailing the mean differences of the scores of the paired experimental and control scars across three observers.Type: ApplicationFiled: February 18, 2005Publication date: February 23, 2006Applicant: Mayo Foundation for Medical Education and Research, a Minnesota corporationInventors: Holger Gassner, David Sherris
-
Publication number: 20040259078Abstract: The invention provides methods to detect VZV in biological samples using real-time PCR. Primers and probes for the detection of VZV are provided by the invention. Articles of manufacture containing such primers and probes for detecting VZV are further provided by the invention.Type: ApplicationFiled: July 6, 2004Publication date: December 23, 2004Applicant: Mayo Foundation for Medical Education and Research, a Minnesota corporationInventors: Mark J. Espy, Jim Uhl, Thomas F. Smith
-
Publication number: 20040253214Abstract: Disclosed are compositions comprising a recombinant nucleic acid vector including a nucleotide sequence encoding a syncytium-inducing polypeptide expressible on a eukaryotic cell surface, and a host cell containing the recombinant vector and expressing the syncytium inducing polypeptide on its cell surface, the vectors and resultant host cells expressing the syncytium inducing polypeptide being useful for selective elimination of unwanted cells,Type: ApplicationFiled: December 10, 2003Publication date: December 16, 2004Applicant: Mayo Foundation For Medical Education and Research, a Minnesota corporationInventors: Stephen James Russell, Frances Joanne Morling, Adele Kay Fielding, Francois-Loic Cosset, Roberto Cattaneo
-
Publication number: 20040242520Abstract: Disclosed is a method of regulating the expression in a human or animal subject of a nucleic acid sequence encoding a polypeptide which is immunogenic in the subject; the method comprising introducing into a mammal a cell comprising the nucleic acid sequence encoding the immunogenic polypeptide, said sequence being operably linked to a drug-regulatable promoter; and altering the concentration of regulatory drug to which the cell is exposed.Type: ApplicationFiled: January 13, 2004Publication date: December 2, 2004Applicant: Mayo Foundation for Medical Education and Research, a Minnesota corporationInventors: Stephen James Russell, Luis Alvarez Vallina, Siamak Agha-Mohammadi, Robert Hawkins
-
Publication number: 20040235098Abstract: Isolated sulfotransferase nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described. Methods for determining a risk estimate for hormone dependent disease and methods for determining sulfonator status also are described.Type: ApplicationFiled: September 23, 2003Publication date: November 25, 2004Applicant: Mayo Foundation for Medical Education and Research, a Minnesota corporationInventors: Richard M. Weinshilboum, Rebecca B. Raftogianis, Thomas C. Wood, Diane M. Otterness
-
Publication number: 20040224889Abstract: The invention involves methods and materials for extracellularly administering PNA oligomers to living cells. Specifically, the invention provides methods and materials of treating living cells with PNA oligomers such that the oligomers cross biological barriers and engender a biological response in a sequence specific manner. In addition, the invention provides methods and materials for orally administering PNA oligomers to animals such that the oligomers cross biological barriers and engender a biological response in a sequence specific manner. The invention also provides sense and antisense PNA oligomers that modulate transcription and translation, respectively. The invention also provides mismatch PNA oligomers that modulate the degree of an engendered biological response. In addition, the invention provides methods and materials for detecting PNA oligomers within a biological sample collected from an animal.Type: ApplicationFiled: March 12, 2004Publication date: November 11, 2004Applicant: Mayo Foundation for Medical Education and Research, a Minnesota corporationInventors: Elliott Richelson, Beth Marie Tyler, Daniel J. McCormick, Bernadette Marie Cusack, Clark V. Hoshall, Christopher Lee Douglas, Karen Jansen
-
Publication number: 20040220108Abstract: The invention provides a novel amino acid, neo-tryptophan, as well as polypeptides containing this novel amino acid such as neurotensin analogs. In addition, the invention provides neo-tryptophan derivatives, serotonin-like neo-tryptophan derivatives, and polypeptides containing such derivatives. The invention also provides methods for making neo-tryptophan, neo-tryptophan derivatives, serotonin-like neo-tryptophan derivatives, and compositions containing these compounds. Further, the invention provides methods for inducing a neurotensin response in a mammal as well as methods for treating a mammal having a serotonin recognition molecule.Type: ApplicationFiled: June 1, 2004Publication date: November 4, 2004Applicant: Mayo Foundation for Medical Education and Research, a Minnesota corporationInventors: Elliott Richelson, Bernadette Marie Cusack, Yuan-Ping Pang, Daniel J. McCormick, Abdul Fauq, Beth Marie Tyler, Mona Boules
-
Publication number: 20040209830Abstract: A novel strategy for monitoring the expression of a transgene in a patient is disclosed. A marker peptide is genetically fused to either the N-terminus or C-terminus of the product of a transgene through a linker peptide which bears the recognition sequence of a host cell protease. Expression of the transgene results in release of the marker peptide into extracellular body fluid of the patient in proportion to the amount of transgene product. The level of the released marker peptide serves as an indicator of the level of transgene expression. The system is particularly useful for monitoring the expression of therapeutic transgenes and production of the therapeutic gene product.Type: ApplicationFiled: August 15, 2003Publication date: October 21, 2004Applicant: Mayo Foundation for Medical Education and Research a Minnesota corporationInventors: Stephen James Russell, Kah Whye Peng
-
Publication number: 20040197844Abstract: Use of pregnancy-associated plasma protein-A as a marker for inflammatory conditions, and in particular, for acute coronary syndromes is described.Type: ApplicationFiled: January 29, 2004Publication date: October 7, 2004Applicant: Mayo Foundation for Medical Education and Research, a Minnesota CorporationInventors: Cheryl A. Conover, Antonio Bayes-Genis, David R. Holmes, Robert S. Schwartz
-
Publication number: 20040185030Abstract: The invention provides methods and materials related to the treatment of inflammatory diseases such as rheumatoid arthritis. Specifically, the invention provides methods and materials for treating inflammation by reducing production of an inflammatory cytokine such as IFN-&ggr;, IL-1&bgr;, and TNF-&agr;. The invention also provides methods and materials for identifying reagents that can be used to treat inflammatory diseases. Specifically, the invention provides non-human animals containing human synovial tissue as well as methods for using such non-human animals to determine the influence of various test reagents on the inflamed state of human synovial tissue.Type: ApplicationFiled: December 10, 2003Publication date: September 23, 2004Applicant: Mayo Foundation for Medical Education and Research , a Minnesota corporationInventors: Jorg J. Goronzy, Cornelia M. Weyand
-
Publication number: 20040167616Abstract: A stent includes a first stent section, a second stent section, and at least one connecting member. The connecting member has a first end attached to the first stent section, a second end attached to the second stent section and a physically separable portion.Type: ApplicationFiled: February 24, 2004Publication date: August 26, 2004Applicant: Mayo Foundation for Medical Education and Research, a Minnesota corporationInventors: Allan R. Camrud, David R. Holmes, Robert S. Schwartz
-
Publication number: 20040161849Abstract: Materials and methods for transferring nucleic acid encoding a polypeptide for treating a disease or disorder into populations of quiescent cells such as haematopoietic stem cells (HSCs), using retroviral packaging cell lines and retroviral particles expressing and displaying a growth factor such as stem cell factor (SCF) on the cell surface or as a fusion with a viral envelope protein. The present invention also relates compositions comprising the retroviral packaging cell lines and viral particles, and their use in methods of medical treatment, in vivo and ex vivo.Type: ApplicationFiled: February 17, 2004Publication date: August 19, 2004Applicant: Mayo Foundation For Medical Education and Research, a Minnesota corporationInventors: Stephen James Russell, Adele Kay Fielding, Colin Maurice Casimir
-
Publication number: 20040148149Abstract: A method for designing a metal ion for use in a MD simulation can include the steps of building a metal ion molecule having a center atom and a dummy atom, assigning a van der Waals radius to the center atom, and assigning a charge to the dummy atom. A metal ion molecule can have. The center atom covalently linked to one or more dummy atoms resulting in the metal ion molecule having a polyhedron geometry. New force field parameters may be used in methods for designing metal ions for use in MD simulations.Type: ApplicationFiled: November 26, 2003Publication date: July 29, 2004Applicant: Mayo Foundation for Medical Education and Research, a Minnesota corporationInventor: Yuan-Ping Pang
-
Publication number: 20040071802Abstract: The invention features methods of reducing the level of a &bgr;-amyloid (A&bgr;) polypeptide using an Cimicifuga extract. The invention also features methods of producing an active fraction from an extract of Cimicifuga. The invention further features a composition containing an active fraction of a Cimicifuga extract and an article of manufacture containing such a composition.Type: ApplicationFiled: October 8, 2003Publication date: April 15, 2004Applicant: Mayo Foundation for Medical Education and Research a Minnesota corporationInventors: Christopher B. Eckman, Debra Yager, Sharie Haugabook, Abdul Fauq
-
Publication number: 20040014118Abstract: The invention provides methods to detect Group A Streptococcus (GAS) in biological samples using real-time PCR. Primers and probes for the detection of GAS are provided by the invention. Articles of manufacture containing such primers and probes for detecting GAS are further provided by the invention.Type: ApplicationFiled: June 19, 2003Publication date: January 22, 2004Applicant: Mayo Foundation for Medical Education and Research , a Minnesota corporationInventors: James R. Uhl, Franklin R. Cockerill
-
Publication number: 20030235532Abstract: A novel strategy for monitoring the location of a transgene in a mammal is disclosed. A sodium iodide symporter is genetically fused to either the N-terminus or C-terminus of the product of a transgene through a linker peptide which bears the recognition sequence of a host cell protease. Expression of the transgene confers the activity of the sodium iodide symporter (NIS)to a host cell which expresses the transgene. Subsequent administration of labeled iodine results in transport of the labeled iodine into the cell bearing the NIS, which can then be localized and measured using standard imaging techniques. The system is particularly useful for monitoring the location of therapeutic transgenes and tissue-specific distribution of the therapeutic gene product.Type: ApplicationFiled: May 1, 2003Publication date: December 25, 2003Applicant: Mayo Foundation for Medical Education and Research , a Minnesota corporationInventors: Stephen James Russell, John Morris
-
Publication number: 20030166505Abstract: The invention provides a novel amino acid, neo-tryptophan, as well as polypeptides containing this novel amino acid such as neurotensin analogs. In addition, the invention provides neo-tryptophan derivatives, serotonin-like neo-tryptophan derivatives, and polypeptides containing such derivatives. The invention also provides methods for making neo-tryptophan, neo-tryptophan derivatives, serotonin-like neo-tryptophan derivatives, and compositions containing these compounds. Further, the invention provides methods for inducing a neurotensin response in a mammal as well as methods for treating a mammal having a serotonin recognition molecule.Type: ApplicationFiled: October 4, 2002Publication date: September 4, 2003Applicant: Mayo Foundation for Medical Education and Research, a Minnesota corporationInventors: Elliott Richelson, Bernadette Marie Cusack, Yuan-Ping Pang, Daniel J. McCormick, Abdul Fauq, Beth Marie Tyler, Mona Boules
-
Publication number: 20030161810Abstract: The invention provides methods and materials related to the treatment of inflammatory diseases such as rheumatoid arthritis. Specifically, the invention provides methods and materials for treating inflammation by reducing production of an inflammatory cytokine such as IFN-&ggr;, IL-1&bgr;, and TNF-&agr;. The invention also provides methods and materials for identifying reagents that can be used to treat inflammatory diseases. Specifically, the invention provides non-human animals containing human synovial tissue as well as methods for using such non-human animals to determine the influence of various test reagents on the inflamed state of human synovial tissue.Type: ApplicationFiled: February 22, 2002Publication date: August 28, 2003Applicant: Mayo Foundation for Medical Education and Research, a Minnesota corporationInventors: Jorg J. Goronzy, Cornelia M. Weyand
-
Publication number: 20030153516Abstract: The invention involves methods and materials for treating and preventing non-invasive fungus-induced mucositis. Specifically, the invention involves administrating an antifungal agent such that it contact mucus in an amount, at a frequency, and for a duration effective to prevent, reduce, or eliminate non-invasive fungus-induced rhinosinusitis. This invention also provides methods and materials for diagnosing non-invasive fungus-induced rhinosinusitis and culturing non-invasive fungus from a mammalian mucus sample as well as specific antifungal formulations and medical devices for treating and preventing non-invasive fungus-induced rhinosinusitis. In addition, the invention provides methods and materials for treating and preventing other non-invasive fungus-induced mucositis conditions such as chronic otitis media, chronic colitis, and Crohn's disease. Further, the invention involves methods and materials for treating and preventing chronic asthma symptoms.Type: ApplicationFiled: November 13, 2002Publication date: August 14, 2003Applicant: Mayo Foundation for Medical Education and Research, a Minnesota corporationInventor: Jens Ponikau