Patents Assigned to Mayo Foundation for Medical Research and Education
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Patent number: 11952633Abstract: The present invention relates to methods and compositions for determination of and uses of specific methylation patterns indicative of adenoma and carcinoma. In particular, the invention relates to analysis of defined CpG loci that are coordinately methylated in DNAs from cancer and adenoma samples, methods for identifying coordinately methylated loci, and methods of using analysis of coordinately methylated loci in one or more marker regions in the design of assays for adenoma and cancer.Type: GrantFiled: November 23, 2020Date of Patent: April 9, 2024Assignees: Exact Sciences Corporation, Mayo Foundation for Medical Research and EducationInventors: David A. Ahlquist, William R. Taylor, Hongzhi Zou, Graham P. Lidgard
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Patent number: 9655726Abstract: A radial-capitellar implant for surgical replacement of the capitellum of the humerus and, optionally, the head of the radius. The radial-capitellar implant includes a capitellar implant or surface replacement arthroplasty of the capitellum and a radial prosthesis for replacement of the head of the radius. In one embodiment the radial prosthesis includes an articular head which moveable articulates with a stem implantable in the radius.Type: GrantFiled: November 28, 2006Date of Patent: May 23, 2017Assignee: Mayo Foundation for Medical Research and EducationInventors: William P. Cooney, III, Bernard F. Morrey, David A. Leibel
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Patent number: 9549826Abstract: A sigmoid notch resurfacing prosthesis for application to the sigmoid notch of the distal radius. The sigmoid notch prosthesis generally includes a saddle and a radius portion for attachment to the distal radius. The saddle may be formed from ultra high molecular weight polyethylene or another durable self-lubricating material. The saddle includes an at least partially concave contoured depression having rounded edges that is securable to the radius portion. The saddle may be secured by a sliding notch snap fit design. The prosthesis may be adapted for articulation with the natural head of the ulna or with an ulnar head prosthesis that has replaced the ulnar head.Type: GrantFiled: June 20, 2012Date of Patent: January 24, 2017Assignee: Mayo Foundation for Medical Research and EducationInventors: William P. Cooney, III, Richard A. Berger, David A. Leibel
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Publication number: 20120259418Abstract: A sigmoid notch resurfacing prosthesis for application to the sigmoid notch of the distal radius. The sigmoid notch prosthesis generally includes a saddle and a radius portion for attachment to the distal radius. The saddle may be formed from ultra high molecular weight polyethylene or another durable self-lubricating material. The saddle includes an at least partially concave contoured depression having rounded edges that is securable to the radius portion. The saddle may be secured by a sliding notch snap fit design. The prosthesis may be adapted for articulation with the natural head of the ulna or with an ulnar head prosthesis that has replaced the ulnar head.Type: ApplicationFiled: June 20, 2012Publication date: October 11, 2012Applicant: MAYO FOUNDATION FOR MEDICAL RESEARCH AND EDUCATIONInventors: William P. Cooney, III, Richard A. Berger, David A. Leibel
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Patent number: 8206453Abstract: A sigmoid notch resurfacing prosthesis for application to the sigmoid notch of the distal radius. The sigmoid notch prosthesis generally includes a saddle and a radius portion for attachment to the distal radius. The saddle may be formed from ultra high molecular weight polyethylene or another durable self-lubricating material. The saddle includes an at least partially concave contoured depression having rounded edges that is securable to the radius portion. The saddle may be secured by a sliding notch snap fit design. The prosthesis may be adapted for articulation with the natural head of the ulnar or with an ulnar head prosthesis that has replaced the ulnar head.Type: GrantFiled: November 27, 2006Date of Patent: June 26, 2012Assignee: Mayo Foundation for Medical Research and EducationInventors: William Cooney, III, David Leibel, Richard Berger
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Publication number: 20080091198Abstract: A carpal fusion plate for use in fusion of the bones of the midcarpus or other bones. The fusion plate is concave and defines at least one round countersunk screw hole and at least one tapered elongate slotted aperture. The tapered elongate slotted aperture is narrower peripherally and broader centrally. The fusion plate also defines a multilobated central opening.Type: ApplicationFiled: December 6, 2007Publication date: April 17, 2008Applicant: MAYO Foundation for Medical Research and EducationInventors: David Leibel, William Cooney, Ronald Linscheid, Richard Berger
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Patent number: 7160331Abstract: A sigmoid notch resurfacing prosthesis for application to the sigmoid notch of the distal radius. The sigmoid notch prosthesis generally includes a saddle and a radius portion for attachment to the distal radius. The saddle may be formed from ultra high molecular weight polyethylene or another durable self-lubricating material. The saddle includes an at least partially concave contoured depression having rounded edges that is securable to the radius portion. The saddle may be secured by a sliding notch snap fit design. The prosthesis may be adapted for articulation with the natural head of the ulna or with an ulnar head prosthesis that has replaced the ulnar head.Type: GrantFiled: December 1, 2004Date of Patent: January 9, 2007Assignee: Mayo Foundation for Medical Research and EducationInventors: William P. Cooney, III, Richard A. Berger, David A. Leibel
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Patent number: 7160329Abstract: A radial-capitellar implant for surgical replacement of the capitellum of the humerus and, optionally, the head of the radius. The radial-capitellar implant includes a capitellar implant or surface replacement arthroplasty of the capitellum and a radial prosthesis for replacement of the head of the radius. In one embodiment the radial prosthesis includes an articular head which moveable articulates with a stem implantable in the radius.Type: GrantFiled: December 1, 2004Date of Patent: January 9, 2007Assignee: Mayo Foundation for Medical Research and EducationInventors: William P. Cooney, III, Bernard F. Morrey, David A. Leibel
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Patent number: 5583104Abstract: A method of inhibiting proliferation of bile duct epithelium, said method comprising the step of contacting said epithelium with an effective amount of somatostatin or a somatostatin agonist.Type: GrantFiled: December 6, 1993Date of Patent: December 10, 1996Assignee: Mayo Foundation for Medical Research and EducationInventor: Nicholas F. LaRusso