Patents Assigned to Mayo Foundation of Medical Education and Research
  • Microbial biofilm removal methods and systems
    Patent number: 8076117
    Abstract: Methods, kits, and systems for removing microbial biofilms from surfaces of objects (such as, e.g., explanted medical devices) are disclosed. The methods, kits, and systems rely on the use of acoustic energy in the presence of microbubbles to enhance biofilm removal while retaining viability of the microorganisms in the biofilm. The microbubbles may be provided in a variety of manners such as, e.g., vortexing a liquid, obtaining a suspension that includes pre-formed protein-stabilized microbubbles, etc.
    Type: Grant
    Filed: March 17, 2005
    Date of Patent: December 13, 2011
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Andrej Trampuz, Robin Patel, James F. Greenleaf, Arlen D. Hanssen
  • APPLICATION OF OPEN AND/OR SHORT STRUCTURES TO BISECT DE-EMBEDDING
    Publication number: 20110298476
    Abstract: Application of open and short structures may result in improved accuracy in determination of ABCD parameters of a substantially symmetric THRU for purposes of bisect de-embedding. Either one or both of the open and/or short techniques may be used to improve results of an ABCD optimization algorithm. Bisect de-embedding may then be performed to determine the ABCD parameters of a device under test based on the ABCD parameters of the substantially symmetric THRU and measured s-parameters of the substantially symmetric THRU and the embedded device under test.
    Type: Application
    Filed: June 7, 2011
    Publication date: December 8, 2011
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Michael J. Degerstrom, Erik S. Daniel
  • Shear wave generation system for medical imaging
    Patent number: 8072216
    Abstract: A system is configured to produce a stress on a subject while performing a magnetic resonance elastography scan in a magnetic resonance imaging (MRI) system. The system includes an active driver operable to produce an energy configured for a magnetic resonance elastography (MRE) process. A passive actuator is configured to be positioned in the MRI system and to be coupled to the subject. The system includes a tube coupling the active driver to the passive actuator to deliver the energy produced by the active driver to the passive actuator, and a strap coupled to the passive actuator. The strap is configured to be disposed around the subject. The strap includes a substantially inelastic material configured to convert the energy delivered to the passive actuator from the tube into shear waves with the subject for use in the MRE process.
    Type: Grant
    Filed: April 3, 2009
    Date of Patent: December 6, 2011
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Richard L. Ehman, Meng Yin, Kevin J. Glaser
  • Polynucleotides encoding for fusion proteins with natriuresis activity
    Patent number: 8063191
    Abstract: This document provides methods and material related to natriuretic polypeptides. For example, substantially pure polypeptides having a natriuretic peptide activity, nucleic acids encoding polypeptides having a natriuretic peptide activity, host cells containing such nucleic acids, and methods for inducing a natriuretic or diuretic activity within a mammal are provided.
    Type: Grant
    Filed: August 11, 2010
    Date of Patent: November 22, 2011
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: John C Burnett, Jr., Timothy M Olson
  • DIAGNOSTIC CAPSULES, DELIVERY/RETRIEVAL SYSTEMS, KITS AND METHODS
    Publication number: 20110282144
    Abstract: Diagnostic capsules, a variety of diagnostic capsule delivery systems for delivering a diagnostic capsule into an animal or human body cavity (e.g., into an animal or human bladder through a urethra), a variety of diagnostic capsule retrieval systems, a variety of kits that include diagnostic capsule delivery and retrieval systems and diagnostic capsules, and methods of using the same are described herein.
    Type: Application
    Filed: November 16, 2009
    Publication date: November 17, 2011
    Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventor: Matthew T. Gettman
  • Neurotensin receptor agonists and opioid receptor agonists
    Patent number: 8058230
    Abstract: This document provides methods and materials for treating pain. For example, this document provides methods that involve administering a neurotensin receptor (NTR) agonist and an opioid receptor agonist to a mammal (e.g., a human). Compositions containing an NTR agonist in combination with an opioid receptor agonist also are provided.
    Type: Grant
    Filed: February 27, 2010
    Date of Patent: November 15, 2011
    Assignees: Sarentis Therapeutics, Inc., Mayo Foundation for Medical Education and Research
    Inventors: Denise Barbut, Elliott Richelson
  • SELECTIVE INHIBITORS OF C-JUN N-TERMINAL KINASE
    Publication number: 20110269810
    Abstract: Compositions and methods for treating, preventing, or ameliorating one or more symptoms, disorders, or conditions associated with particular c-Jun N-terminal kinase(s) (JNKs) activity are provided. Compositions contain small molecules such as pyrazoloanthrones.
    Type: Application
    Filed: April 4, 2011
    Publication date: November 3, 2011
    Applicants: Regents of the University of Minnesota, Mayo Foundation for Medical Education and Research
    Inventors: Yuan-Ping Pang, Anuradha Vummenthala, Jewn Giew Park, Shao-Hua Wang, Zigang Dong, Ann M. Bode, Yong Yeon Cho
  • DETERMINATION OF PHOTODYNAMIC THERAPY (PDT) TREATMENT PARAMETERS
    Publication number: 20110270056
    Abstract: A photodynamic therapy system and methods determine the amount (concentration) of a photosensitizer agent present in the target tissue. The system may also determine the tissue oxygenation. The system may also determine light dosimetry parameters based on the amount of photosensitizer in the tissue and/or the tissue oxygenation.
    Type: Application
    Filed: April 20, 2011
    Publication date: November 3, 2011
    Applicants: College of Charleston, Mayo Foundation for Medical Education and Research
    Inventors: Linda R. Jones, Nathan J. Towles, Fletcher B. Moore, Herbert C. Wolfsen, Michael B. Wallace
  • SPECIALIZED SEARCH ENGINES
    Publication number: 20110270843
    Abstract: A specialized search engine tool designed for subject matter experts facilitates access to information relevant to their area of expertise available on public domains over the Internet. The specialized search engine represents the collection of thousands of links that are sorted, resorted, categorized and placed into databases that interact with one another. The specialized search engine may permit a user to compare results from multiple databases and automatically submit their search query to many popular searchable databases and web sites from a central web page, without having to individually visit each site. In one example, the specialized search engine is a medical search engine.
    Type: Application
    Filed: November 3, 2010
    Publication date: November 3, 2011
    Applicant: Mayo Foundation for Medical Education and Research
    Inventor: Scott M. Albin
  • METHODS AND DEVICES FOR LIGATING TUBULAR STRUCTURES
    Publication number: 20110270275
    Abstract: The devices and methods described herein may be used to ligate tissue, e.g., tubular structures where access is limited by using a sheath to deliver one or more sutures that can be deflected such that the end of the sheath forms a curve.
    Type: Application
    Filed: September 8, 2009
    Publication date: November 3, 2011
    Applicant: Mayo Foundation for Medical Education and Research
    Inventor: Stephen D. Cassivi
  • MUSCULO-SKELETAL MESH AND FIXATION SYSTEM
    Publication number: 20110270284
    Abstract: A surgical mesh product and a method for attaching the surgical method product to a patient's bodily tissue. The surgical mesh product includes a fixation structure can be a grommet, an interwoven fiber or thread, or a reinforcing material. The fixation structure strengthens the mesh material (e.g. enhances the rip and/or tear strength) at locations where screws, tacks or other fasteners will be applied to secure the mesh product to a patient. The surgical mesh product is suitable for use in hernia repair.
    Type: Application
    Filed: October 2, 2009
    Publication date: November 3, 2011
    Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventors: Christopher P. Beauchamp, James M. Swain
  • Sulfotransferase 1E1 sequence variants
    Patent number: 8048662
    Abstract: Isolated sulfotransferase nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as well as sulfotransferase allozymes. Methods for determining if a mammal is predisposed to cancer also are described.
    Type: Grant
    Filed: April 5, 2011
    Date of Patent: November 1, 2011
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Araba A. Adjei, Eric D. Wieben, Richard M. Weinshilboum, Bianca A. Thomae
  • Spinal fixation support device and methods of using
    Patent number: 8043341
    Abstract: The invention provides for a spinal fixation support device to be used in conjunction with spinal fixation instrumentation. The invention further provides for methods of using the spinal fixation support device. In addition, the invention provides for a spinal fixation system that includes a spinal fixation support device of the invention and can further include spinal fixation instrumentation.
    Type: Grant
    Filed: December 13, 2005
    Date of Patent: October 25, 2011
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Chunfeng Zhao, Bradford L. Currier, Fredrick M. Schultz, Kai-Nan An
  • B7-DC variants
    Patent number: 8039589
    Abstract: Variant costimulatory polypeptides, nucleic acids encoding such polypeptides, and methods for using the polypeptides and nucleic acids to enhance a T cell response are provided herein.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: October 18, 2011
    Assignee: Mayo Foundation for Medical Education and Research
    Inventor: Lieping Chen
  • Colonoscopy Tracking and Evaluation System
    Publication number: 20110251454
    Abstract: A system for tracking and evaluating a colonoscopy procedure performed using an endoscope includes a tracking subsystem, a processing subsystem and a display subsystem. The tracking subsystem provides information representative of the location of the endoscope within a patient's colon during the procedure. The processing subsystem generates visualization metrics from images produced by the endoscope during the procedure. The display subsystem is coupled to the tracking and processing subsystems to generate a visual display of the patient's colon with information representative of the visualization metrics at associated colon locations.
    Type: Application
    Filed: November 23, 2009
    Publication date: October 13, 2011
    Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventors: Richard A. Robb, Gianrico Farrugia, William J. Sandborn, David R. Holmes, III
  • Methods and probes for detecting esophageal cancer
    Patent number: 8034577
    Abstract: Probe sets and methods of using probes and probe sets for selectively detecting high grade dysplasia and esophageal adenocarcinoma or low grade dysplasia from biologic samples are described. Methods of the invention include contacting a biological sample obtained from a subject with a set of chromosomal probes to selectively detect an esophageal carcinoma or precursor lesion in the sample, if any, under conditions for specifically hybridizing the probes to their nucleic targets present in the sample. The presence or absence of high grade dysplasia and esophageal adenocarcinoma or low grade dysplasia is thereafter specifically determined from the hybridization pattern detected for the set of chromosomal probes to the biological sample.
    Type: Grant
    Filed: February 17, 2006
    Date of Patent: October 11, 2011
    Assignees: Mayo Foundation for Medical Education and Research, Abbott Laboratories, Inc.
    Inventors: Kevin Halling, Larry E. Morrison, Shannon Brankley
  • SULFOTRANSFERASE 1E1 SEQUENCE VARIANTS
    Publication number: 20110244547
    Abstract: Isolated sulfotransferase nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as well as sulfotransferase allozymes. Methods for determining if a mammal is predisposed to cancer also are described.
    Type: Application
    Filed: April 5, 2011
    Publication date: October 6, 2011
    Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventors: Araba A. Adjei, Eric D. Wieben, Richard M. Weinshilboum, Bianca A. Thomae
  • B7-H5, A COSTIMULATORY POLYPEPTIDE
    Publication number: 20110245468
    Abstract: B7-HS costimulatory polypeptides, nucleic acids encoding such polypeptides, and methods for using the polypeptides and nucleic acids to enhance a T cell response are provided herein.
    Type: Application
    Filed: February 28, 2011
    Publication date: October 6, 2011
    Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventor: Lieping Chen
  • KASPP (LRRK2) gene, its production and use for the detection and treatment of neurodegenerative disorders
    Patent number: 8029986
    Abstract: The present invention refers to a newly discovered gene named KASPP for Kinase Associated with Parkinsonism with Pleiomorphic Pathology or alternatively named LRRK2 for Leucine-Rich Repeat Kinase 2, its production, biochemical characterization and use for the detection and treatment of neurodegenerative disorders, such as Parkinson disease (PD) including, without limitation, sporadic PD, Alzheimer disease (AD), amyotrophic lateral sclerosis (ALS), and other synucleinopathies and/or tauopathy as well as several polymorphisms and mutations in the KASPP/LRRK2 gene segregated with PD.
    Type: Grant
    Filed: September 27, 2005
    Date of Patent: October 4, 2011
    Assignees: Helmholtz Zentrum Muenchen Deutsches Forschungszentrum fuer Gesundheit und Umwelt(GmbH), Eberhard Karls Universitaet Tuebingen, Mayo Foundation for Medical Education and Research
    Inventors: Thomas Meitinger, Tim Matthias Strom, Saskia Biskup, Marius Ueffing, Elisabeth Kremmer, Christian Johannes Gloeckner, Thomas Gasser, Petra Herzig, Friedrich Asmus, Nadja Patenge, Alexander Zimprich, Matthew J. Farrer, Jennifer M. Kachergus, Sara J. Lincoln, Mary M. Hulihan, Zibigniew Wszolek, Ryan Uitti
  • Electronic stool subtraction in CT colonography
    Patent number: 8031921
    Abstract: A method for processing CT colonography input image voxel data representative of 3-dimensional images of a colon having gas and stool tagged with stool tagging agent, to remove the stool from the images. The input image voxel data is generated by an imaging instrument having a characteristic point spread function representative of instrument blurring. The point spread function of the instrument can be empirically determined, and the image data processed as a function of the point spread function to accurately identify and remove the tagged stool. In one embodiment of the invention, portions of the image data representative of the tagged stool and colon tissue are dilated as a function of the point spread function.
    Type: Grant
    Filed: February 14, 2006
    Date of Patent: October 4, 2011
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Armando Manduca, Michael J. Carston, Robert J. Wentz, C. Daniel Johnson