Abstract: The present invention is directed to conopeptides termed conkunitzins and their use for blocking the flow of potassium ions through voltage-gated potassium channels. In view of the Kunitz domain in the conkunitzins, they are also useful for inhibiting platelet aggregation and as protease inhibitors.
Type:
Application
Filed:
September 9, 2005
Publication date:
August 10, 2006
Applicants:
University of Utah Research Foundation, Cognetix, Inc., Maz-Planck-Gesellschaft zur Forderung der Wissenschaften e.V.
Inventors:
Baldomero Olivera, Heinrich Terlau, Julita Imperial, James Garrett