Abstract: Provided herein is a novel method for creating fixed, non-antagonistic molar ratios of drugs in and around the bone environment for desired periods of time. This method enables treating bone and bone-related disease by administering a pharmaceutical composition comprising a bone-targeted therapeutic agent able to release a drug payload from the bone surface, in addition to a second therapeutic agent. Such methods are useful in the treatment of bone and bone-related diseases, such as cancer-induced bone disease, osteomyelitis and bone infection, bone pain and inflammatory bone disease, metabolic disease, as well as others.
Abstract: Provided herein are conjugates of nucleoside antimetabolites and their analogs with ibandronate, pharmaceutical compositions including one or more of said conjugates, methods of synthesizing the same as well as methods of treating diseases and or conditions using the same.
Abstract: Provided herein is a novel method for creating fixed, non-antagonistic molar ratios of drugs in and around the bone environment for desired periods of time. This method enables treating bone and bone-related disease by administering a pharmaceutical composition comprising a bone-targeted therapeutic agent able to release a drug payload from the bone surface, in addition to a second therapeutic agent. Such methods are useful in the treatment of bone and bone-related diseases, such as cancer-induced bone disease, osteomyelitis and bone infection, bone pain and inflammatory bone disease, metabolic disease, as well as others.
Abstract: The present invention provides novel bisphosphonate conjugates, pharmaceutical compositions comprising bisphosphonate conjugates and methods of using such analogs in the treatment of bone cancer, bone-related diseases, bone infection, bone inflammation, and diseases of the soft tissues surrounding bones.
Type:
Grant
Filed:
December 14, 2015
Date of Patent:
August 14, 2018
Assignee:
MBC PHARMA, INC.
Inventors:
Alexander Karpeisky, Shawn Patrick Zinnen
Abstract: Compounds and compositions are provided, as are methods of using them to treat infections, neoplastic disease, including pancreatic cancer, inflammatory disease, and pain. Such compounds are nucleotides, acyclonucleotides, and ANP phosphonates conjugated with forms and/or moieties of Vitamin B6 for delivery past the cell membrane and into the cell.
Type:
Grant
Filed:
August 1, 2012
Date of Patent:
May 10, 2016
Assignee:
MBC PHARMA, INC.
Inventors:
Alexander Karpeisky, Shawn Zinnen, Murali Urlam, Vladimir Y. Vvedensky, Andrei P. Guzaev
Abstract: The present invention provides novel bisphosphonate conjugates, pharmaceutical compositions comprising bisphosphonate conjugates and methods of using such analogs in the treatment of bone cancer, bone-related diseases, bone infection, bone inflammation, and diseases of the soft tissues surrounding bones.
Type:
Grant
Filed:
October 25, 2013
Date of Patent:
December 22, 2015
Assignee:
MBC PHARMA, INC.
Inventors:
Alexander Karpeisky, Shawn Patrick Zinnen
Abstract: Provided herein are compounds, compositions, and methods of using them to treat infections, neoplastic disease, inflammatory disease, and pain. Such compounds are nucleotides, acyclonucleotides, and ANP phosphonates conjugated with forms and/or moieties of Vitamin B6 for delivery past the cell membrane and into the cell.
Type:
Application
Filed:
August 1, 2012
Publication date:
November 6, 2014
Applicant:
MBC PHARMA, INC.
Inventors:
Alexander Karpeisky, Shawn Zinnen, Murali Urlam, Vladimir Y. Vvedensky, Andrei P. Guzaev
Abstract: The present invention provides novel bisphosphonate conjugates, pharmaceutical compositions comprising bisphosphonate conjugates and methods of using such analogs in the treatment of bone cancer, bone-related diseases, bone infection, bone inflammation, and diseases of the soft tissues surrounding bones.
Type:
Application
Filed:
October 25, 2013
Publication date:
February 20, 2014
Applicant:
MBC Pharma, Inc.
Inventors:
Alexander Karpeisky, Shawn Patrick Zinnen
Abstract: The present invention provides novel bisphosphonate conjugates, pharmaceutical compositions comprising bisphosphonate conjugates and methods of using such analogs in the treatment of bone cancer, bone-related diseases, bone infection, bone inflammation, and diseases of the soft tissues surrounding bones.
Type:
Grant
Filed:
March 30, 2009
Date of Patent:
November 19, 2013
Assignee:
MBC Pharma, Inc.
Inventors:
Alexander Karpeisky, Shawn Patrick Zinnen
Abstract: The present invention provides novel bisphosphonate conjugates, pharmaceutical compositions comprising bisphosphonate conjugates and methods of using such analogs in the treatment of bone cancer, bone-related diseases and diseases of the soft tissues surrounding bones.
Abstract: The present invention provides novel bisphosphonate conjugates, pharmaceutical compositions comprising bisphosphonate conjugates and methods of using such analogs in the treatment of bone cancer, bone-related diseases, bone infection, bone inflammation, and diseases of the soft tissues surrounding bones.