Abstract: The present invention relates to a novel quinoline or quinazoline compound and the use thereof. The compound according to the present invention shows an excellent inhibitory activity against cytochrome P450 4A (CYP4A) and thus may be utilized for preventing, relieving or treating metabolic diseases.

Abstract: The present invention relates to a novel quinoline compound and a use thereof and to a novel quinoline compound exhibiting CYP4A inhibition activity and a use thereof for preventing, alleviating, treating a metabolic disease. The compound disclosed in the present invention has a remarkable effect of inhibiting CYP4A and exhibits the activities of promoting the absorption of glucose into hepatocytes, inhibiting fat accumulation in hepatocytes, suppressing endoplasmic reticulum-induced reactive oxygen species, and treating steatohepatitis, and thus can be very advantageously used for developing therapeutics for metabolic diseases such as diabetes mellitus and fatty liver.

Abstract: The present invention is directed to a method of measuring cell migration by measuring the invasion ratio of cells incubated on a pillar array inserted into a well structure, the method including steps of: preparing a pillar array having a plurality of micropillars and a well structure having a plurality of microwells into which the plurality of micropillars is insertable, respectively; forming cell spheroids by incubating cells in an extracellular matrix attached to the end contact surfaces of the micropillars; allowing the cells contained in the cell spheroids to invade the end contact surfaces; staining and scanning the cell spheroids, the cells contained in the cell spheroids, and the cells that invaded the end contact surfaces; and calculating the invasion ratio of cells by the following equation through a fluorescence image of the scanned cells: Invasion ? Ratio = Invasion ? cell ? area Total ? cell ? area = A Total - A spheroid A Total [ Equation ] wherei

Abstract: Technology for a pillar structure for a biochip is disclosed. The pillar structure for a biochip includes: a substrate portion having a plate structure; an insertion pillar portion formed in one piece with the substrate portion and protruding downward from a lower surface of the substrate portion so as to be inserted into a well; and a compensation pillar portion formed in one piece with the substrate portion, the compensation pillar portion corresponding to the insertion pillar portion and protruding upward from an upper surface of the substrate portion. Therefore, when the pillar structure is cooled during an injection molding process, the substrate portion is prevented from being partially recessed, and when samples are analyzed using microscopic images, accuracy and reliability may be improved.

Abstract: The present invention relates to a pillar structure for a biochip. The pillar structure for a biochip according to the present invention is provided to form a biochip for analyzing a sample, which is a biological micromaterial such as a cell, together with a well plate configured to receive a culture solution, and the pillar structure includes: a pillar part having a seating surface on which a cell for culture is placed, and a light irradiation surface configured to be irradiated with light for observing the cell placed on the seating surface; and a plurality of holder parts extending in a state of being spaced apart from the pillar part and having an opening between the adjacent holder parts so that the culture solution is introduced between the holder parts.

Abstract: The present invention relates to a pillar structure for a biochip and includes a substrate which has a plate-shaped structure, and pillar members, each of which has one side detachably coupled to the substrate and the other side on which a sample is disposed.

Abstract: A pillar unit for a bio chip can include a plate-form substrate having a plurality of holder parts, which are spaced apart from each other, and each of the plurality of holder parts includes a holding space, to which a pillar is inserted and fixed, in which each of the plurality of holder parts further includes a pair transformation slits so that the corresponding holder part may be transformed and restored while the pillar is accommodated in the holding space; and a plurality of pillars corresponding to the plurality of holder parts, each of the plurality of pillars is accommodated in the holding space in one of the plurality of holder parts, one end of each of the plurality of pillars is combined with one holder part among the plurality of holder parts and is detachable, and the other end of each of the pillars includes a sample.

Abstract: Technology for a biochip pillar structure is disclosed. According to an embodiment of the present disclosure, the biochip pillar structure includes: a pillar structure including a plate-shaped first substrate portion, and pillar portions protruding from a surface of the first substrate portion; and a well structure including a plate-shaped second substrate portion, and well portions formed in a surface of the second substrate portion and having a predetermined depth to respectively receive the pillar portions of the pillar structure, wherein the well portions have a diameter within a range of 800 ?m to 1500 ?m, and the pillar portions configured to be inserted into the well portions have a diameter of which the ratio to the diameter of the well portions ranges from 0.3 to 0.58, thereby providing a high-density biochip and preventing bubbling in an aqueous liquid contained in the well portions when the pillar portions are inserted.

Abstract: Provided is a pillar unit for a bio chip. The pillar unit for a bio chip according to the present invention is to form a bio chip along with a well plate, in which a culture medium is accommodated, wherein the bio chip analyzes samples of biological micro-substances such as cells, and may include: a plate-form substrate including a plurality of holder parts, which is spaced apart from each other, arranged vertically and horizontally, and includes a holding space, to which an object is inserted and fixed, wherein each of the holder parts includes transformation slits so that the holder part may be transformed and restored while the object is accommodated in the holding space; and a plurality of pillars corresponding to the above object which is accommodated in the holding space of the substrate, wherein one end of the pillar is combined with each holder part and is detachable, and the other end of the pillar includes the sample.

Abstract: The present invention relates to a pillar structure for a biochip and includes a substrate which has a plate-shaped structure, and pillar members, each of which has one side detachably coupled to the substrate and the other side on which a sample is disposed.