Abstract: Methods of genetically modifying microorganisms using advanced genome editing are disclosed. Methods of modifying the genome of these microorganisms for point mutations, deletions, and DNA insertions are also disclosed. Further, inhibiting expression of genes without manipulating the genome of the microorganism is disclosed. In some cases, the microorganism can be a methylotroph, e.g., a methanotroph.
Type:
Grant
Filed:
October 11, 2018
Date of Patent:
February 20, 2024
Assignee:
MBP TITAN, LLC
Inventors:
Xuezhi Li, James Kealey, Kevin Lee Dietzel
Abstract: Methods of genetically modifying microorganisms using advanced genome editing are disclosed. Methods of modifying the genome of these microorganisms for point mutations, deletions, and DNA insertions are also disclosed. Further, inhibiting expression of genes without manipulating the genome of the microorganism is disclosed. In some cases, the microorganism can be a methylotroph, e.g., a methanotroph.
Type:
Application
Filed:
October 11, 2018
Publication date:
October 14, 2021
Applicant:
MBP TITAN LLC
Inventors:
Xuezhi Li, James Kealey, Kevin Lee Dietzel