Patents Assigned to MBrace Therapeutics, Inc.
  • Antibody-Drug Conjugates Against the Receptor Tyrosine Kinase EphA5
    Publication number: 20240115722
    Abstract: The present invention relates in certain aspects to antibodies, binding polypeptides, and immunoconjugates specific for human EPH receptor A5 (EphA5).
    Type: Application
    Filed: July 27, 2023
    Publication date: April 11, 2024
    Applicants: Rutgers, The State University of New Jersey, MBrace Therapeutics, Inc.
    Inventors: Renata Pasqualini, Wadih Arap, Fernanda I. Staquicini
  • CELL-FREE METHODS OF PRODUCING ANTIBODIES TO INTRACELLULAR TARGETS
    Publication number: 20240068004
    Abstract: Provided herein are methods and cell-free systems for production of a recombinant antibody in which the antibody is directed against a target protein that is natively expressed as an intracellular protein. Also provided herein are modified cell-free systems for use in such methods in which the cell free protein expression system is modified by an agent which binds to the intracellular target protein or to the antibody paratope and thus prevents the antibody from binding to the target protein.
    Type: Application
    Filed: May 2, 2023
    Publication date: February 29, 2024
    Applicant: MBrace Therapeutics, Inc.
    Inventors: Yongjian Wu, Fernanda I. Staquicini, Isan Chen
  • CELL-FREE METHODS OF RECOMBINANT ANTIBODY PRODUCTION
    Publication number: 20240010714
    Abstract: Provided herein are methods and cell-free systems for production of a recombinant antibody in which the antibody is directed against a target protein that is natively expressed as an intracellular protein. Also provided herein are modified cell-free systems for use in such methods in which the modified system is engineered to express a variant target protein that has a mutant epitope of the target epitope of an antibody.
    Type: Application
    Filed: May 2, 2023
    Publication date: January 11, 2024
    Applicant: MBrace Therapeutics, Inc.
    Inventors: Yongjian Wu, Fernanda I. Staquicini, Isan Chen
  • METHODS OF RECOMBINANT ANTIBODY PRODUCTION AND RELATED CELL SYSTEMS
    Publication number: 20230416798
    Abstract: Provided herein are methods and cell systems for production of a recombinant antibody in cells in which the antibody is directed against a target protein that is natively expressed as an intracellular protein in the cell. Also provided herein are modified cell lines for use in such methods in which the modified cell line is engineered to express a variant target protein that has a mutant epitope of the target epitope of an antibody.
    Type: Application
    Filed: May 2, 2023
    Publication date: December 28, 2023
    Applicant: MBrace Therapeutics, Inc.
    Inventors: Fernanda I. Staquicini, Renata Pasqualini
  • ANTIBODY-DRUG CONJUGATES AGAINST THE RECEPTOR TYROSINE KINASE EPHA5
    Publication number: 20230293710
    Abstract: The present invention relates in certain aspects to antibodies, binding polypeptides, and immunoconjugates specific for human EPH receptor A5 (EphA5).
    Type: Application
    Filed: November 3, 2022
    Publication date: September 21, 2023
    Applicants: Rutgers, The State University of New Jersey, MBrace Therapeutics, Inc.
    Inventors: Renata Pasqualini, Wadih Arap, Fernanda I. Staquicini