Abstract: A catheter flushing device includes a chamber covered with a movable member (e.g., a flexible diaphragm) that can be compressed by exertion of pressure on the diaphragm; and a valve having a first position allowing fluid from a fluid source to fill the chamber, and a second position allowing fluid from the chamber to flow through the catheter when pressure is exerted on the movable member. In particular, the catheter flushing device includes a housing having a cylindrical valve opening, an inlet port for connection with the fluid source, and an outlet port for connection with the catheter. The chamber is defined by a flexible diaphragm sealed about a region of the housing. The chamber can be compressed by manually exerting pressure on the diaphragm by means of a thumb or finger. A passageway extends through the housing from the chamber to the valve opening.