Patents Assigned to McLean Hospital Corporation
  • CNS assay for prediction of therapeutic efficacy for neuropathic pain and other functional illnesses
    Patent number: 7860552
    Abstract: In general, the invention features methods for identifying therapeutic interventions for functional illnesses, e.g., neuropathic pain or depression, and methods for identifying markers for functional illnesses by employing an acute painful stimulus or other stimulus for a functional illness and measuring levels of CNS activity.
    Type: Grant
    Filed: September 30, 2005
    Date of Patent: December 28, 2010
    Assignee: The McLean Hospital Corporation
    Inventors: David Borsook, Lino Becerra, Marnie Shaw
  • Diagnosis of attention deficit hyperactivity disorder
    Patent number: 7807362
    Abstract: This invention features methods and compositions useful for the treatment and diagnosis of attentional disorders including attention deficit hyperactivity disorder (ADHD). Also disclosed are methods for identifying compounds useful for such therapy.
    Type: Grant
    Filed: February 14, 2007
    Date of Patent: October 5, 2010
    Assignee: The McLean Hospital Corporation
    Inventors: Kwang-Soo Kim, Chun-Hyung Kim
  • PYRIMIDINES, SUCH AS URIDINE, IN TREATMENTS FOR PATIENTS WITH BIPOLAR DISORDER
    Publication number: 20100222296
    Abstract: The invention is based on the discovery that specific dosages of pyrimidine compositions, such as uridine compositions, can be used to treat patients diagnosed with bipolar disorder.
    Type: Application
    Filed: May 12, 2010
    Publication date: September 2, 2010
    Applicant: The McLean Hospital Corporation
    Inventor: Perry Renshaw
  • Pyrimidines, such as uridine, in treatments for patients with bipolar disorder
    Patent number: 7737128
    Abstract: The invention is based on the discovery that specific dosages of pyrimidine compositions, such as uridine compositions, can be used to treat patients diagnosed with bipolar disorder.
    Type: Grant
    Filed: June 10, 2005
    Date of Patent: June 15, 2010
    Assignee: The McLean Hospital Corporation
    Inventor: Perry Renshaw
  • R(-)-11-HYDROXYAPORPHINE DERIVATIVES AND USES THEREOF
    Publication number: 20100081651
    Abstract: The invention features derivatives of R(?)-11-hydroxyaporphines and methods of treating Parkinson's disease, sexual dysfunction, and depressive disorders therewith.
    Type: Application
    Filed: December 4, 2009
    Publication date: April 1, 2010
    Applicant: The McLean Hospital Corporation
    Inventors: John L. Neumeyer, Ross L. Baldessarini
  • CORTICOSTEROID CONJUGATES AND USES THEREOF
    Publication number: 20100056488
    Abstract: The invention features corticosteroids conjugated to either a charged group or a bulky group in a manner that resists in vivo cleavage, the resulting conjugate is a peripherally acting steroid with reduced activity in the central nervous system. The invention provides a method for treating a patient having an inflammatory disease by administering to the patient a corticosteroid conjugate.
    Type: Application
    Filed: November 4, 2009
    Publication date: March 4, 2010
    Applicant: The McLean Hospital Corporation
    Inventors: Martin H. Teicher, Susan L. Andersen-Navalta
  • R(—)-11-hydroxyaporphine derivatives and uses thereof
    Patent number: 7648995
    Abstract: The invention features derivatives of R(—)-11-hydroxyaporphines and methods of treating Parkinson's disease, sexual dysfunction, and depressive disorders therewith.
    Type: Grant
    Filed: April 13, 2005
    Date of Patent: January 19, 2010
    Assignee: The McLean Hospital Corporation
    Inventors: John L. Neumeyer, Ross J. Baldessarini
  • Salvinorin derivatives and uses thereof
    Patent number: 7629475
    Abstract: The invention features salvinorin compositions that are selective for kappa opioid receptors; methods of treating mania by using a selective kappa receptor agonist; and methods of treating mood disorders, such as depressive disorders and manic disorders, using salvinorin compositions.
    Type: Grant
    Filed: March 14, 2005
    Date of Patent: December 8, 2009
    Assignee: The McLean Hospital Corporation
    Inventors: Cécile Béquin, William A. Carlezon, Bruce M. Cohen, Minsheng He, David Yue-Wei Lee, Michele R. Richards, Lee-Yuan Liu-Chen
  • Compounds for the treatment of tobacco dependence and withdrawal
    Patent number: 7601701
    Abstract: The invention provides methods for treating or suppressing tobacco or nicotine usage or dependence involving administration of a therapeutically-effective amount of a cytosine-containing or cytidine-containing compound, creatine-containing compound, adenosine-containing, or adenosine-elevating compound to a mammal.
    Type: Grant
    Filed: May 25, 2006
    Date of Patent: October 13, 2009
    Assignee: The McLean Hospital Corporation
    Inventor: Scott Lukas
  • Multimerized enhancer domains for cell-specific expression
    Patent number: 7585962
    Abstract: The invention features an enhancer cassette and methods of its use. The enhancer cassette has the formula [X?Y]n, wherein each X is independently a cell type-specific enhancer element; Y is absent or is a mono or polynucleotide that has between one and thirty nucleotides; and n is an integer between five and fifty, inclusive.
    Type: Grant
    Filed: October 21, 2002
    Date of Patent: September 8, 2009
    Assignee: The McLean Hospital Corporation
    Inventors: Kwang-Soo Kim, Ole Isacson, Dong-Youn Hwang
  • Methods for the Treatment of ADHD and Related Disorders
    Publication number: 20090221552
    Abstract: The invention features methods, compositions, and kits for the treatment of attention deficit hyperactivity disorder and related behavioral disorders by administering an organic cation 3 (hOCT3) inhibitor.
    Type: Application
    Filed: February 27, 2007
    Publication date: September 3, 2009
    Applicant: The McLean Hospital Corporation
    Inventors: Martin Teicher, Susan L. Andersen, Jacqueline A. Samson
  • Method For Assessing Auditory Attention And Vigilance
    Publication number: 20090202966
    Abstract: Provided are methods for assessing the attentional state of a subject by scoring the subject's response to auditory stimuli. The methods can be used to diagnose psychological and behavioral disorders, such as attention deficit disorder or hyperkinetic disorder.
    Type: Application
    Filed: August 24, 2005
    Publication date: August 13, 2009
    Applicant: The Mclean Hospital Corporation
    Inventors: Martin H. Teicher, Dennis M. Kim
  • Inter-subject coherence in DT-MRI
    Patent number: 7570049
    Abstract: A method for estimating a value of a diffusion tensor includes obtaining, from a plurality of test subjects, DT-MRI data from which an initial estimate of the tensor can be derived. Values indicative of intra-subject variation and inter-subject variation in the data are then determined. These values are used to determine a subject-specific additive offset for adjusting the DT-MRI data.
    Type: Grant
    Filed: April 6, 2005
    Date of Patent: August 4, 2009
    Assignee: McLean Hospital Corporation
    Inventor: Nicholas T. Lange
  • PYRIMIDINES, SUCH AS URIDINE, IN TREATMENTS FOR PATIENTS WITH BIPOLAR DISORDER
    Publication number: 20090054370
    Abstract: The invention is based on the discovery that specific dosages of pyrimidine compositions, such as uridine compositions, can be used to treat patients diagnosed with bipolar disorder.
    Type: Application
    Filed: June 10, 2005
    Publication date: February 26, 2009
    Applicant: MCLEAN HOSPITAL CORPORATION
    Inventor: Perry Renshaw
  • Methods for the treatment of mood disorders
    Publication number: 20090048177
    Abstract: The invention features methods of treating mood disorders, such as manic disorders, and stabilizing moods by administering a kappa agonist or partial agonist to a subject in need thereof.
    Type: Application
    Filed: August 27, 2008
    Publication date: February 19, 2009
    Applicant: The McLean Hospital Corporation
    Inventors: Bruce M. Cohen, Beth L. Murphy
  • Apparatus and Method for Convection Enhanced Therapeutic Delivery
    Publication number: 20080287917
    Abstract: A system for convection enhanced delivery of therapeutic comprises one or more flexible, biocompatible microcatheters that are directed to a target location to deliver a therapeutic agent. The microcatheter is releasably coupled to a guide tube and directed to the desired location. The microcatheters are small and flexible in order to reach the target areas, minimize trauma at the injection site, and minimize reflux of the injectable therapeutic.
    Type: Application
    Filed: May 19, 2008
    Publication date: November 20, 2008
    Applicant: The McLean Hospital Corporation
    Inventor: Miles G. Cunningham
  • Methods for diagnosis and prognosis of psychotic disorders
    Publication number: 20080009010
    Abstract: The invention features methods diagnostic of a psychotic disorder such as bipolar disorder or schizophrenia. The methods include obtaining a cell sample from a subject, subjecting a cell from the sample to stress (e.g., nutrient stress), and measuring nucleic acid or polypeptide expression in the cell, where an alteration in expression is indicative of the subject having or being at increased risk of developing a psychotic disorder. The invention also features prognostic monitoring methods for subjects having a psychotic disorder, useful in determining the progression of a psychotic disorder in a subject or the effectiveness of a therapy.
    Type: Application
    Filed: May 18, 2007
    Publication date: January 10, 2008
    Applicant: The McLean Hospital Corporation
    Inventor: Christine Konradi
  • Treatment of cocaine abuse using N-substituted derivatives of morphinan
    Patent number: 7291628
    Abstract: The invention is based in part on the discovery that nonselective ? agonists that possess ? receptor-mediated effects in addition to their ? agonist effects can decrease cocaine self-administration more effectively and with fewer undesirable side effects than can highly selective ? agonists. The invention includes a number of new compounds having both nonselective ? opioid receptor agonist activity and additional activity at ? opioid receptors. These compounds are useful for the treatment of cocaine abuse, and can also be radiolabeled for use as imaging agents, e.g., the N-fluoroalkyl and iodoalkyl derivatives can be used, respectively, for positron emission tomography (PET) and single photon computed tomography (SPECT) brain imaging.
    Type: Grant
    Filed: January 4, 2005
    Date of Patent: November 6, 2007
    Assignee: McLean Hospital Corporation
    Inventors: John L. Neumeyer, Jean M. Bidlack, Xiao-Hui Gu
  • Magnetic field stimulation techniques
    Patent number: 7282021
    Abstract: The invention involves enhancing brain function by stimulating the brain using magnetic fields. Applications of the new methods include improving the condition of individuals with cognitive disorders, such as depression, and studying the effects of neural stimulation using induced electric fields. These techniques can avoid deleterious effects of psychotropic pharmaceutical treatments, and provide a relatively safe, comfortable, inexpensive means of direct cranial stimulation.
    Type: Grant
    Filed: April 13, 2006
    Date of Patent: October 16, 2007
    Assignee: McLean Hospital Corporation
    Inventors: Michael L. Rohan, Aimee Parow, Perry F. Renshaw
  • Mixed opioids and uses thereof
    Patent number: 7271173
    Abstract: This invention features opioid compounds having activity at kappa and mu receptors, methods for preparing the mu/kappa opioids, and methods for the treatment of pain or a dopamine dysregulation disease, such as schizophrenia, attention deficit hyperactivity disorder (ADHD), attention deficit hyperactivity disorder (ADD), Parkinson's disease, hyperprolactinemia, depression, and addiction.
    Type: Grant
    Filed: November 18, 2003
    Date of Patent: September 18, 2007
    Assignee: The McLean Hospital Corporation
    Inventors: John L. Neumeyer, Ao Zhang