Abstract: This invention relates to compositions comprising a tramadol material selected from the group consisting of tramadol, its stereoisomers and its pharmaceutically acceptable salts and either codeine or oxycodone, and their use in treating pain. When the components, i.e., tramadol materials and either of codeine or oxycodone, of the composition are within certain ratios of pharmacological effects of the compositions are superaddditive (synergistic).
Abstract: An improved coating pan apparatus and spray arm assembly are disclosed for providing facilitated maintenance and cleaning of sensitive spray nozzles. The spray arm assembly includes means for varying the spray length and spray angle from a position external to the coating drum. Additionally, this invention provides adjustment means for removing the fixture containing the spray nozzles entirely from the coating drum and laterally from the coating apparatus housing for purging.
Abstract: Sulfamates of the following formula (I): ##STR1## wherein X is O or CH.sub.2 and R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are as herein defined have been found to exhibit anticonvulsant activity and are thus useful in the treatment of conditions such as epilepsy. Further, pharmaceutical compositions containing a compound of formula (I) as well as methods for their use and intermediates form part of the present invention.
Abstract: Loweralkyl 1-methylpyrrole-2-acetates are prepared by the recuction of loweralkyl .alpha.-imino-1-methylpyrrole-2-acetates using a divalent sulfur reducing agent.
Type:
Grant
Filed:
October 16, 1978
Date of Patent:
August 5, 1980
Assignee:
McNeil Lab, Inc.
Inventors:
John R. Carson, Richard J. Carmosin, Anthony T. Stefanski
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